Thymoglobulin induction protects liver allografts from ischemia/reperfusion injury

Abstract:  Background:  Interventions that minimize hepatic ischemia/reperfusion injury (IRI) can expand the donor organ pool. Thymoglobulin (TG) induction therapy has been shown to ameliorate delayed graft function and possibly decrease IRI in cadaver renal transplants recipients. This controlled randomized trial was designated to assess the ability of TG to protect against IRI in liver transplant recipients.

[1]  G. Farrell,et al.  Dual role of tumor necrosis factor‐α in hepatic ischemia‐reperfusion injury: Studies in tumor necrosis factor‐α gene knockout mice , 2004 .

[2]  K. Messmer,et al.  Glutathione Protects the Rat Liver Against Reperfusion Injury After Prolonged Warm Ischemia , 2004, Annals of surgery.

[3]  M. Shimada,et al.  The hydroxyl radical scavenger MCI‐186 protects the liver from experimental cold ischaemia–reperfusion injury , 2004, The British journal of surgery.

[4]  Sun-Mee Lee,et al.  Effect of trolox on altered vasoregulatory gene expression in hepatic ischemia/reperfusion , 2004, Archives of pharmacal research.

[5]  C. Broelsch,et al.  Value of Energy Substrates in HTK and UW to Protect Human Liver Endothelial Cells against Ischemia and Reperfusion Injury , 2004, European Surgical Research.

[6]  G. Farrell,et al.  Dual role of tumor necrosis factor-alpha in hepatic ischemia-reperfusion injury: studies in tumor necrosis factor-alpha gene knockout mice. , 2004, Hepatology.

[7]  M. Dogan,et al.  Two-day induction with thymoglobulin in kidney transplantation: risks and benefits. , 2004, Transplantation proceedings.

[8]  A. Tannapfel,et al.  Assessment of hepatic ischemia-reperfusion injury by simultaneous measurement of tissue pO2, pCO2, and pH. , 2004, Microvascular research.

[9]  Sun-Mee Lee,et al.  Role of kupffer cells in the vasoregulatory gene expression during hepatic ischemia/reperfusion , 2004, Archives of pharmacal research.

[10]  S. Fuggle,et al.  Cadaveric versus living-donor livers: differences in inflammatory markers after transplantation , 2003, Transplantation.

[11]  L. Liang,et al.  Protective mechanism of L-arginine against liver ischemic-reperfusion injury in rats. , 2003, Hepatobiliary & pancreatic diseases international : HBPD INT.

[12]  E. Albano,et al.  Recent insights on the mechanisms of liver preconditioning. , 2003, Gastroenterology.

[13]  H. Jaeschke,et al.  Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury. , 2003, Gastroenterology.

[14]  J. Wernerman,et al.  Glutathione metabolism in human liver after ischemia and reperfusion , 2003 .

[15]  G. Farrell,et al.  Hepatic ischemia reperfusion injury: Pathogenic mechanisms and basis for hepatoprotection , 2003, Journal of gastroenterology and hepatology.

[16]  S. Wolf,et al.  Immunomodulation of hepatic ischemic injury via increased Bcl-X(L) and decreased Bcl-X(S). , 2003, The Journal of surgical research.

[17]  R. Busuttil,et al.  Hepatic ischemia/reperfusion injury--a fresh look. , 2003, Experimental and molecular pathology.

[18]  L. Genestier,et al.  Functional antibodies to leukocyte adhesion molecules in antithymocyte globulins1 , 2003, Transplantation.

[19]  D. Brennan.  Functional Antibodies to Leukocyte Adhesion Molecules in Antithymocyte Globulins. , 2003 .

[20]  R. Stratta,et al.  Improving results in solitary pancreas transplantation with portal-enteric drainage, thymoglobin induction, and tacrolimus/mycophenolate mofetil-based immunosuppression , 2003, Transplant international : official journal of the European Society for Organ Transplantation.

[21]  H. Jaeschke.  Role of Reactive Oxygen Species in Hepatic Ischemia-Reperfusion Injury and Preconditioning , 2003, Journal of investigative surgery : the official journal of the Academy of Surgical Research.

[22]  F. Delmonico,et al.  A prospective, randomized, clinical trial of intraoperative versus postoperative thymoglobulin in adult cadaveric renal transplant recipients , 2003 .

[23]  R. Wyatt,et al.  Short-term outcomes of Thymoglobulin induction in pediatric renal transplant recipients , 2002, Pediatric Nephrology.

[24]  R. Stratta,et al.  Thymoglobulin for induction or rejection therapy in pancreas allograft recipients: a single centre experience , 2002, Clinical transplantation.

[25]  R. Colvin,et al.  Identification of the CD4(+) T cell as a major pathogenic factor in ischemic acute renal failure. , 2001, The Journal of clinical investigation.

[26]  S. Hubscher,et al.  ARE PARENCHYMAL CHANGES IN EARLY POST-TRANSPLANT BIOPSIES RELATED TO PRESERVATION-REPERFUSION INJURY OR REJECTION? , 2001, Transplantation.

[27]  D. Geller,et al.  Protective role of the L-arginine-nitric oxide synthase pathway on preservation injury after rat liver transplantation. , 2001, JPEN. Journal of parenteral and enteral nutrition.

[28]  J. Revillard,et al.  MECHANISMS INVOLVED IN ANTITHYMOCYTE GLOBULIN IMMUNOSUPPRESSIVE ACTIVITY IN A NONHUMAN PRIMATE MODEL 1 , 2001, Transplantation.

[29]  G. Loss,et al.  Steroid-free immunosuppression through thymoglobulin induction in liver transplantation. , 2001, Transplantation proceedings.

[30]  M. Manyalich,et al.  l-ARGININE REDUCES LIVER AND BILIARY TRACT DAMAGE AFTER LIVER TRANSPLANTATION FROM NON-HEART-BEATING DONOR PIGS1 , 2000, Transplantation.

[31]  M. Schnitzler,et al.  A randomized, double-blinded comparison of Thymoglobulin versus Atgam for induction immunosuppressive therapy in adult renal transplant recipients. , 1999, Transplantation.

[32]  J. Visa,et al.  S-adenosyl L-methionine effect on hepatic allografts procured from non-heart-beating donor pigs. , 1999, Transplantation proceedings.

[33]  D. Renlund,et al.  Antilymphocyte-antibody prophylaxis: review of the adult experience in heart transplantation. , 1997, Transplantation proceedings.

[34]  R. Guttmann,et al.  Use of thymoglobulin induction therapy in the prevention of acute graft rejection episodes following liver transplantation. , 1997, Transplantation proceedings.

[35]  J. Engelhardt,et al.  CD4(+) T-lymphocytes mediate ischemia/reperfusion-induced inflammatory responses in mouse liver. , 1997, The Journal of clinical investigation.

[36]  K. Nadeau,et al.  The cytokine-adhesion molecule cascade in ischemia/reperfusion injury of the rat kidney. Inhibition by a soluble P-selectin ligand. , 1997, The Journal of clinical investigation.

[37]  P. Howdle,et al.  Reperfusion injury, antioxidants and hemodynamics during orthotopic liver transplantation , 1994, Hepatology.

[38]  L. Toledo-Pereyra,et al.  NEUTROPHIL INFILTRATION AS AN IMPORTANT FACTOR IN LIVER ISCHEMIA AND REPERFUSION INJURY , 1993, Transplantation.

[39]  M. Shimada,et al.  Ischemic injury in liver transplantation: Difference in injury sites between warm and cold ischemia in rats , 1992, Hepatology.

[40]  T. Starzl,et al.  Extended preservation of human liver grafts with UW solution. , 1989, JAMA.