Controversy and Strategies Exploration in Blocking Mother-to-Child Transmission of Hepatitis B

Hepatitis B, a serious infectious disease caused by the hepatitis B virus (HBV), remains a worldwide social and public health problem. Hepatitis B has a particularly high incidence rate in the world, whereas approximately 35–50% HBV carriers are infected through vertical transmission. Even after newborn immunoprophylaxis, vertical transmission still accounts for 5–10% in China according to plenty of literature in Chinese language. For these reasons, it is important to determine how to effectively intervene in mother-to-child transmission (MTCT). To date, though, intervention methods and measures remain controversial. In order to understand the mechanism of MTCT intervention further and develop effective preventions and interventions, a comprehensive analysis and presentation on some of its more controversial issues will be given in this paper. And eventually we conclude three measures and strategies for these issues: (1) emancipate the mind and seek truth from facts to understand the controversial issues pertaining to MTCT of HBV; (2) treat the basic rules and changing characteristics of MTCT blocking process of hepatitis B with holistic medical thought dialectically and (3) further explore the interaction of genetic susceptibility and environmental factors of MTCT of hepatitis B.

[1]  H. El‐Serag,et al.  Epidemiology of hepatocellular carcinoma in the United States: Where are we? Where do we go? , 2014, Hepatology.

[2]  Xiaomao Li,et al.  Mother‐to‐child transmission of HBV: review of current clinical management and prevention strategies , 2014, Reviews in medical virology.

[3]  E. Swenson,et al.  Prevention of neonatal hepatitis B virus transmission. , 2014, Journal of clinical gastroenterology.

[4]  Aifen Zhou,et al.  Immunoprophylaxis Failure Against Vertical Transmission of Hepatitis B Virus in the Chinese Population: A Hospital-based Study and a Meta-analysis , 2014, The Pediatric infectious disease journal.

[5]  H. Patton,et al.  Management of hepatitis B during pregnancy , 2014, Nature Reviews Gastroenterology &Hepatology.

[6]  G. Borgia,et al.  Prevention of mother-to-child transmission of hepatitis B virus and hepatitis C virus , 2014, Expert review of anti-infective therapy.

[7]  James S. Park,et al.  Current recommendations of managing HBV infection in preconception or pregnancy , 2014, Frontiers of Medicine.

[8]  Xiaomin Xiao,et al.  Risk factors for intrauterine infection with hepatitis B virus , 2014, International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.

[9]  P. Ye,et al.  Breast feeding and immunoprophylaxis efficacy of mother-to-child transmission of hepatitis B virus , 2014, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.

[10]  B. Hocher,et al.  Telbivudine during the second and third trimester of pregnancy interrupts HBV intrauterine transmission: a systematic review and meta-analysis. , 2014, Clinical laboratory.

[11]  H. Ren,et al.  Measures to Reduce Mother-to-Child Transmission of Hepatitis B Virus in China: A Meta-Analysis , 2014, Digestive Diseases and Sciences.

[12]  M. Hudson,et al.  Hepatitis B in pregnancy , 2013, Frontline Gastroenterology.

[13]  Z. Duan,et al.  Cesarean section reduces perinatal transmission of hepatitis B virus infection from hepatitis B surface antigen-positive women to their infants. , 2013, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[14]  K. Michalak,et al.  Prevention of mother‐to‐child transmission of hepatitis B virus (HBV) during pregnancy and the puerperium: Current standards of care , 2013, The Australian & New Zealand journal of obstetrics & gynaecology.

[15]  L. Feng,et al.  Risk factors of HBV intrauterine transmission among HBsAg‐positive pregnant women , 2013, Journal of viral hepatitis.

[16]  Hongying Hou,et al.  Identification of risk factors associated with immunoprophylaxis failure to prevent the vertical transmission of hepatitis B virus. , 2013, The Journal of infection.

[17]  Yu-zhu Yin,et al.  [Identification of risk factors related to the failure of immunization to interrupt hepatitis B virus perinatal transmission]. , 2013, Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.

[18]  Yali Hu,et al.  Breastfeeding Is Not a Risk Factor for Mother-to-Child Transmission of Hepatitis B Virus , 2013, PloS one.

[19]  Tan Liemin.  The blocking effect on mother-infant dissemination of HBV from combined immunization at different stage of pregnancy , 2013 .

[20]  Wei Zhang,et al.  Cost-effectiveness analysis of preventing mother-to-child transmission of hepatitis B by injecting hepatitis B immune globulin , 2012, European journal of gastroenterology & hepatology.

[21]  Biao Xu,et al.  Combined prophylaxis is still better than vaccine only in children of HBV-infected mothers with negative HBeAg. , 2012, Gastroenterology.

[22]  F. Liu,et al.  Follow-up study of blocking transmission of HBV from mother to children , 2012 .

[23]  T. Lau,et al.  Breastfeeding initiation: is this influenced by maternal hepatitis B infection? , 2012, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.

[24]  T. Tran.  Hepatitis B: Treatment to prevent perinatal transmission. , 2012, Clinical obstetrics and gynecology.

[25]  Jia-Horng Kao,et al.  Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update , 2012, Hepatology International.

[26]  Xiaofeng Liang,et al.  An algorithm for risk assessment and intervention of mother to child transmission of hepatitis B virus. , 2012, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[27]  Ashish Kumar.  Hepatitis B virus infection and pregnancy: a practical approach , 2012, Indian Journal of Gastroenterology.

[28]  Q. Le.  Protective effect of Hepatitis B vaccine combined with two-dose Hepatitis B immunoglobulin on infants born from HBsAg-positive mothers. , 2012 .

[29]  Han Feng-jua.  Research progress in understanding the mechanisms and interruption of vertical transmission of hepatitis B virus , 2012 .

[30]  Hong-wei Zhang,et al.  A meta-analysis of lamivudine for interruption of mother-to-child transmission of hepatitis B virus. , 2011, World journal of gastroenterology.

[31]  S. Wen,et al.  A nested case-control study of maternal-neonatal transmission of hepatitis B virus in a Chinese population. , 2011, World journal of gastroenterology.

[32]  J. Preiksaitis,et al.  Factors associated with vaccine failure and vertical transmission of hepatitis B among a cohort of Canadian mothers and infants , 2011, Journal of viral hepatitis.

[33]  Yihan Lu,et al.  Should chronic hepatitis B mothers breastfeed? a meta analysis , 2011, BMC public health.

[34]  Sheng Qiu-ju.  HBV mother-to-child transmission block-agreement and controversy , 2011 .

[35]  Jia Ji-dong,et al.  [The guideline of prevention and treatment for chronic hepatitis B (2010 version)]. , 2011, Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.

[36]  M. H. Hasanjani Roushan,et al.  Outcomes of passive-active immunoprophylaxis given to infants of mothers infected with hepatitis B virus in Babol, Iran. , 2010, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

[37]  M. Petrova,et al.  Breastfeeding and chronic HBV infection: clinical and social implications. , 2010, World journal of gastroenterology.

[38]  Manoj Kumar,et al.  Pregnancy and chronic hepatitis B virus infection , 2010, Hepatology research : the official journal of the Japan Society of Hepatology.

[39]  Chen Weiqun,et al.  Analysis of correlation factors of intrauterine interruption failure for HBV infected pregnant women using HBIG during the last trimester of pregnancy. , 2010 .

[40]  D. Zhongping.  Effect of different delivery modes on mother-to-infant transmission of hepatitis B virus , 2010 .

[41]  Liu Quanhong,et al.  Correlative study on blocking effect of hepatitis B immunoglobulin combined with hepatitis B vaccine on mother-infant transmission of hepatitis B virus. , 2010 .

[42]  Jiang Jianhua,et al.  Sequence analysis on HBV DNA "a" determinant mutation in children failed in HBIG vaccination. , 2009 .

[43]  L. Heng.  Study on relationship between serum HBV DNA load or HBVM in HBsAg positive pregnant women and intrauterine HBV infection , 2009 .

[44]  Lian-san Zhao,et al.  Elective caesarean section versus vaginal delivery for preventing mother to child transmission of hepatitis B virus – a systematic review , 2008, Virology Journal.

[45]  Wang Hu.  Clinical study on hepatitis B immune globins and hepatitis B virus vaccine preventive effect to interdict hepatitis B virus transmission from pregnant women to embryos by intrauterin infection , 2007 .

[46]  Si Duan-qi.  Preventing of HBV mother-infant transmission using hepatitis B immune globins and hepatitis B virus vaccine on neonates with HBV infection in PBMC. , 2006 .

[47]  Liu Dong-yun.  Study on interruption of the vertical transmission of HBV by HBIG , 2005 .

[48]  Ye Dong-qing.  Cause of immunoprophyaxis failure to intrauterine infection of HBV , 2004 .

[49]  Holly R. Wilson,et al.  Hepatitis B and you: a patient education resource for pregnant women and new mothers. , 2003, Journal of women's health.

[50]  Xh Wang,et al.  BREASTFEEDING DOES NOT POSE ANY ADDITIONAL RISK OF IMMUNOPROPHYLAXIS FAILURE ON INFANTS OF HBV CARRIER MOTHERS , 2003, International journal of clinical practice.

[51]  Jianshe Wang,et al.  Effect of delivery mode on maternal-infant transmission of hepatitis B virus by immunoprophylaxis. , 2002, Chinese medical journal.

[52]  Yu Guangjun.  A randomized controlled trial on interruption of HBV transmission in uterus , 2002 .

[53]  A. Kumar,et al.  Immunoprophylaxis of hepatitis B virus infection. , 2001, Indian journal of medical microbiology.

[54]  G. E. Pakes,et al.  Clinical Pharmacokinetics of Lamivudine , 1999, Clinical pharmacokinetics.

[55]  Ding‐Shinn Chen,et al.  Hepatitis B Virus Infection , 2007 .

[56]  Shu-lin Zhang,et al.  Relationship between HBV viremia level of pregnant women and intrauterine infection:neated PCR for detection of HBV DNA. , 1998, World journal of gastroenterology.

[57]  R. De Vries,et al.  Failure of neonatal hepatitis B vaccination: the role of HBV-DNA levels in hepatitis B carrier mothers and HLA antigens in neonates. , 1994, Journal of hepatology.

[58]  D. Burns,et al.  Extrahepatic hepatitis B virus DNA sequences in patients with acute hepatitis B infection , 1990, Hepatology.

[59]  M. de Martino,et al.  Should hepatitis B surface antigen positive mothers breast feed? , 1985, Archives of disease in childhood.

[60]  J. Villeneuve.  [Immunoprophylaxis of hepatitis B]. , 1984, L'union medicale du Canada.

[61]  Lutwick Li.  Immunoprophylaxis of hepatitis B. , 1982 .

[62]  H. Ip,et al.  TRANSMISSION OF HEPATITIS B ANTIGENS FROM SYMPTOM FREE CARRIER MOTHERS TO THE FETUS AND THE INFANT , 1980, British journal of obstetrics and gynaecology.

[63]  V. Wong,et al.  Mechanisms of maternal-fetal transmission of hepatitis B virus. , 1978, The Journal of infectious diseases.