Mini ReviewHuman Interferons Alpha, Beta and Omega

Type I interferons (IFNs), IFN-α, IFN-β, IFN-ω, IFN-δ and IFN-τ are a family of structurally related, species-specific proteins found only in vertebrates. They exhibit a variety of biological functions, including antiviral, antiproliferative, immunomodulatory and developmental activities. Human Type I IFNs interact with the human IFN alpha receptor (IFNAR), which is composed of two identified subunits (IFNAR-1 and IFNAR-2). The interaction of IFN-α/β with its receptor components results in the activation of a number of signaling pathways. The regulation of specific genes and proteins contributes to the numerous biological functions of Type I IFNs.

[1]  D. Levy,et al.  Role of p38α Map Kinase in Type I Interferon Signaling* , 2004, Journal of Biological Chemistry.

[2]  Daniel R. Caffrey,et al.  LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF , 2003, The Journal of experimental medicine.

[3]  D. Kalvakolanu,et al.  Alternate interferon signaling pathways. , 2003, Pharmacology & therapeutics.

[4]  J. Lord,et al.  Inhibition of Neutrophil Apoptosis by Type 1 IFN Depends on Cross-Talk Between Phosphoinositol 3-Kinase, Protein Kinase C-δ, and NF-κB Signaling Pathways1 , 2003, The Journal of Immunology.

[5]  L. Platanias.  The p38 mitogen-activated protein kinase pathway and its role in interferon signaling. , 2003, Pharmacology & therapeutics.

[6]  L. Platanias,et al.  Interferon-α / β-Receptor Interactions: A Complex Story Unfolding , 2002 .

[7]  M. David.  Signal transduction by type I interferons. , 2002, BioTechniques.

[8]  Michael G. Katze,et al.  Viruses and interferon: a fight for supremacy , 2002, Nature Reviews Immunology.

[9]  E. Fish,et al.  Review: IFN-α/β Receptor Interactions to Biologic Outcomes: Understanding the Circuitry , 2002 .

[10]  L. Platanias,et al.  The CrkL adapter protein is required for type I interferon-dependent gene transcription and activation of the small G-protein Rap1. , 2002, Biochemical and biophysical research communications.

[11]  T. Taniguchi,et al.  The interferon-α/β system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors , 2002 .

[12]  K. Zoon,et al.  Human IFN-α Protein Engineering: The Amino Acid Residues at Positions 86 and 90 Are Important for Antiproliferative Activity1 , 2001, The Journal of Immunology.

[13]  G Schreiber,et al.  New Structural and Functional Aspects of the Type I Interferon-Receptor Interaction Revealed by Comprehensive Mutational Analysis of the Binding Interface* , 2000, The Journal of Biological Chemistry.

[14]  S. Goodbourn,et al.  Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures. , 2000, The Journal of general virology.

[15]  L. Platanias,et al.  Signaling pathways activated by interferons. , 1999, Experimental hematology.

[16]  G. Stark,et al.  How cells respond to interferons. , 1998, Annual review of biochemistry.

[17]  M. Guillomot,et al.  Interferon-delta: the first member of a novel type I interferon family. , 1998, Biochimie.

[18]  J. Martal,et al.  IFN-tau: a novel subtype I IFN1. Structural characteristics, non-ubiquitous expression, structure-function relationships, a pregnancy hormonal embryonic signal and cross-species therapeutic potentialities. , 1998, Biochimie.

[19]  M. Battegay,et al.  Interferon-alpha activates signal transducers and activators of transcription 5 and 6 in Daudi cells. , 1998, European journal of biochemistry.

[20]  G. Foster,et al.  Are all Type I human interferons equivalent? , 1998, Journal of viral hepatitis.

[21]  S. Bass,et al.  Structure-function study of the extracellular domain of the human IFN-alpha receptor (hIFNAR1) using blocking monoclonal antibodies: the role of domains 1 and 2. , 1998, Journal of immunology.

[22]  H. Senn,et al.  The three-dimensional high resolution structure of human interferon alpha-2a determined by heteronuclear NMR spectroscopy in solution. , 1997, Journal of molecular biology.

[23]  L. Pfeffer,et al.  The Short Form of the Interferon α/β Receptor Chain 2 Acts as a Dominant Negative for Type I Interferon Action* , 1997, The Journal of Biological Chemistry.

[24]  J. Langer,et al.  Contributions of cloned type I interferon receptor subunits to differential ligand binding 1 , 1997, FEBS letters.

[25]  A. Hruza,et al.  Zinc mediated dimer of human interferon-alpha 2b revealed by X-ray crystallography. , 1996, Structure.

[26]  L. Platanias,et al.  Differences in Interferon α and β Signaling , 1996, The Journal of Biological Chemistry.

[27]  E. Croze,et al.  Reconstitution of a High Affinity Binding Site for Type I Interferons (*) , 1995, The Journal of Biological Chemistry.

[28]  M. Adler,et al.  Homology model of human interferon‐α8 and its receptor complex , 1995 .

[29]  B. Cohen,et al.  The human interferon-αgb receptor: Characterization and molecular cloning , 1994 .

[30]  B. Cohen,et al.  The human interferon α β receptor: Characterization and molecular cloning , 1994, Cell.

[31]  A. Korn,et al.  Three-Dimensional Model of a Human Interferon-α Consensus Sequence , 1994 .

[32]  K. Zoon,et al.  Evidence for multiple binding sites for several components of human lymphoblastoid interferon-alpha. , 1993, The Journal of biological chemistry.

[33]  G. Lutfalla,et al.  Behavior of a cloned murine interferon alpha/beta receptor expressed in homospecific or heterospecific background. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[34]  L. Platanias,et al.  Interferon-alpha/beta-receptor interactions: a complex story unfolding. , 2002, Current pharmaceutical design.

[35]  G. Sen,et al.  Viruses and interferons. , 2001, Annual review of microbiology.

[36]  W. Lipscomb,et al.  The crystal structure of human interferon b at 2.2-Å resolution , 1997 .

[37]  D. Reardon,et al.  Human type I interferon receptor, IFNAR, is a heavily glycosylated 120-130 kD membrane protein. , 1995, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[38]  G. Lutfalla,et al.  α and α Interferons and Their Receptor and Their Friends and Relations , 1995 .

[39]  J. Langer,et al.  Intrinsic ligand binding properties of the human and bovine alpha-interferon receptors. , 1994, FEBS Letters.