Influence of forces on peri-implant bone.

Occlusal forces affect an oral implant and the surrounding bone. According to bone physiology theories, bones carrying mechanical loads adapt their strength to the load applied on it by bone modeling/remodeling. This also applies to bone surrounding an oral implant. The response to an increased mechanical stress below a certain threshold will be a strengthening of the bone by increasing the bone density or apposition of bone. On the other hand, fatigue micro-damage resulting in bone resorption may be the result of mechanical stress beyond this threshold. In the present paper literature dealing with the relationship between forces on oral implants and the surrounding bone is reviewed. Randomized controlled as well as prospective cohorts studies were not found. Although the results are conflicting, animal experimental studies have shown that occlusal load might result in marginal bone loss around oral implants or complete loss of osseointegration. In clinical studies an association between the loading conditions and marginal bone loss around oral implants or complete loss of osseointegration has been stated, but a causative relationship has not been shown.

[1]  C W Smith,et al.  Measurement of Bite Force in Dogs: A Pilot Study , 1995, Journal of veterinary dentistry.

[2]  A. Ekfeldt,et al.  Implant-supported overdenture therapy: a retrospective study. , 1997, The International journal of prosthodontics.

[3]  A. Holmen,et al.  Histomorphometric and removal torque analysis for TiO2-blasted titanium implants. An experimental study on dogs. , 1992, Clinical oral implants research.

[4]  M W Bidez,et al.  ISSUES IN BONE MECHANICS RELATED TO ORAL IMPLANTS , 1992, Implant dentistry.

[5]  G. Carlsson,et al.  Long-term marginal periimplant bone loss in edentulous patients. , 2000, The International journal of prosthodontics.

[6]  R. Shinkai,et al.  Bruxism and voluntary maximal bite force in young dentate adults. , 2005, The International journal of prosthodontics.

[7]  K. Ikebe,et al.  Association of bite force with ageing and occlusal support in older adults. , 2005, Journal of dentistry.

[8]  P. Branemark,et al.  Marginal tissue reactions at osseointegrated titanium fixtures (I). A 3-year longitudinal prospective study. , 1986, International journal of oral and maxillofacial surgery.

[9]  P. Dechow,et al.  Occlusal force and craniofacial biomechanics during growth in rhesus monkeys. , 1990, American journal of physical anthropology.

[10]  J. Lindhe,et al.  Bone reactions adjacent to titanium implants subjected to static load of different duration. A study in the dog (III). , 2001, Clinical oral implants research.

[11]  U. Lekholm,et al.  Prevalence of subjects with progressive bone loss at implants. , 2005, Clinical oral implants research.

[12]  M. Quirynen,et al.  Microbial differences in 2 clinically distinct types of failures of osseointegrated implants , 1991 .

[13]  M. Manz Factors associated with radiographic vertical bone loss around implants placed in a clinical study. , 2000, Annals of periodontology.

[14]  Paul E Quinlan,et al.  Immediate and early loading of SLA ITI single-tooth implants: an in vivo study. , 2005, The International journal of oral & maxillofacial implants.

[15]  G E Carlsson,et al.  Bone resorption around fixtures in edentulous patients treated with mandibular fixed tissue-integrated prostheses. , 1988, The Journal of prosthetic dentistry.

[16]  F. Isidor,et al.  Mobility assessment with the Periotest system in relation to histologic findings of oral implants. , 1998, The International journal of oral & maxillofacial implants.

[17]  Shuichi Nomura,et al.  Biomechanical aspects of marginal bone resorption around osseointegrated implants: considerations based on a three-dimensional finite element analysis. , 2004, Clinical oral implants research.

[18]  G. Wolfinger,et al.  IMMEDIATE LOADING OF BRÅNEMARK IMPLANTS IN EDENTULOUS MANDIBLES: A PRELIMINARY REPORT , 1997, Implant dentistry.

[19]  A. Ruggeri,et al.  An histologic and histomorphometric study of bone reactions to unloaded and loaded non-submerged single implants in monkeys: a pilot study. , 1993, The Journal of oral implantology.

[20]  I. Naert,et al.  Biologic response of immediately versus delayed loaded implants supporting ill-fitting prostheses: an animal study. , 2005, Clinical implant dentistry and related research.

[21]  D. Ström,et al.  Fatigue development during electrical stimulation in the masseter muscle of rhesus monkeys (Macaca mulatta). , 1994, Archives of oral biology.

[22]  J. Lindhe,et al.  Bone reactions adjacent to titanium implants subjected to static load. A study in the dog (I). , 2001, Clinical oral implants research.

[23]  H. Wehrbein,et al.  Endosseous titanium implants during and after orthodontic load--an experimental study in the dog. , 1993, Clinical oral implants research.

[24]  M R Rieger,et al.  Finite element analysis of six endosseous implants. , 1990, The Journal of prosthetic dentistry.

[25]  A. Piattelli,et al.  Bone remodeling in immediately loaded and unloaded titanium dental implants: a histologic and histomorphometric study in humans. , 2005, The Journal of oral implantology.

[26]  E. Keller,et al.  The influence of mandibular dentition on implant failures in bone-grafted edentulous maxillae. , 2002, The International journal of oral & maxillofacial implants.

[27]  Z. Jacobson,et al.  A prospective multicenter clinical trial of 3i machined-surface implants: results after 6 years of follow-up. , 2003, The International journal of oral & maxillofacial implants.

[28]  G. Alpaslan,et al.  Extracellular alkaline phosphatase activity as a possible marker for wound healing: a preliminary report. , 1997, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[29]  M. Quirynen,et al.  Freestanding and tooth-implant connected prostheses in the treatment of partially edentulous patients Part II: An up to 15-years radiographic evaluation. , 2001, Clinical oral implants research.

[30]  D A Nagel,et al.  Humeral hypertrophy in response to exercise. , 1977, The Journal of bone and joint surgery. American volume.

[31]  U Linden,et al.  A retrospective multicenter evaluation of osseointegrated implants supporting overdentures. , 1988, The International journal of oral & maxillofacial implants.

[32]  P I Brånemark,et al.  A 15-year study of osseointegrated implants in the treatment of the edentulous jaw. , 1981, International journal of oral surgery.

[33]  Bruce Martin,et al.  Aging and strength of bone as a structural material , 2005, Calcified Tissue International.

[34]  G. Gómez-Román,et al.  Effect of occlusal wear on bone loss and Periotest value of dental implants. , 2001, The International journal of prosthodontics.

[35]  Y Zilberman,et al.  Osseous adaptation to continuous loading of rigid endosseous implants. , 1984, American journal of orthodontics.

[36]  I Herrmann,et al.  A 5-year prospective multicenter follow-up report on overdentures supported by osseointegrated implants. , 1996, The International journal of oral & maxillofacial implants.

[37]  A. Ekfeldt,et al.  A retrospective analysis of factors associated with multiple implant failures in maxillae. , 2001, Clinical oral implants research.

[38]  M. Manz Radiographic assessment of peri-implant vertical bone loss: DICRG Interim Report No. 9. , 1997, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[39]  J Gunne,et al.  Osseointegrated implants in edentulous jaws: a 2-year longitudinal study. , 1990, The International journal of oral & maxillofacial implants.

[40]  Cox Jf,et al.  The longitudinal clinical efficacy of osseointegrated dental implants: a 3-year report. , 1987 .

[41]  G C Michaels,et al.  Effect of prosthetic superstructure accuracy on the osteointegrated implant bone interface. , 1997, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[42]  C E Misch,et al.  A Bone Quality‐Based Implant System: A Preliminary Report of Stage I & Stage II , 1998, Implant dentistry.

[43]  D. Pavlin,et al.  Effect of mechanical loading on periodontal cells. , 2001, Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists.

[44]  T Jemt,et al.  Osseointegrated implants in the treatment of partially edentulous patients: a preliminary study on 876 consecutively placed fixtures. , 1989, The International journal of oral & maxillofacial implants.

[45]  Werner Zechner,et al.  Histologic and histomorphometric analysis of three types of dental implants following 18 months of occlusal loading: a preliminary study in baboons. , 2005, Clinical oral implants research.

[46]  D Buser,et al.  Long-term evaluation of non-submerged ITI implants. Part 1: 8-year life table analysis of a prospective multi-center study with 2359 implants. , 1997, Clinical oral implants research.

[47]  R. Haas,et al.  Peri-implant bone loss as a function of tooth-implant distance. , 2005, The International journal of prosthodontics.

[48]  C. Misch,et al.  The causes of early implant bone loss: myth or science? , 2002, Journal of periodontology.

[49]  Flemming lsidor Clinical probing and radiographic assessment in relation to the histologic bone level at oral implants in monkeys , 1997 .

[50]  G. Ricci,et al.  Crestal bone resorption 5 years after implant loading: clinical and radiologic results with a 2-stage implant system. , 2004, The International journal of oral & maxillofacial implants.

[51]  N. Lang,et al.  The microbiota associated with successful or failing osseointegrated titanium implants. , 1987, Oral microbiology and immunology.

[52]  A. Piattelli,et al.  Immediate loading of titanium plasma-sprayed implants: an histologic analysis in monkeys. , 1998, Journal of periodontology.

[53]  Kitetsu Shin,et al.  The influence of controlled occlusal overload on peri-implant tissue. part 4: a histologic study in monkeys. , 1998, The International journal of oral & maxillofacial implants.

[54]  T. Miyata,et al.  Experimental Study of Occlusal Trauma to Osseointegrated Implant. Part 1. , 1997 .

[55]  J. Feryn,et al.  Clinical and Biologic Factors Related to Oral Implant Failure: A 2-Year Follow-Up Study , 2005, Implant dentistry.

[56]  R. Haas,et al.  Radiologic follow-up of peri-implant bone loss around machine-surfaced and rough-surfaced interforaminal implants in the mandible functionally loaded for 3 to 7 years. , 2004, The International journal of oral & maxillofacial implants.

[57]  I Naert,et al.  The influence of static and dynamic loading on marginal bone reactions around osseointegrated implants: an animal experimental study. , 2001, Clinical oral implants research.

[58]  M. Esposito,et al.  Histopathologic observations on late oral implant failures. , 2000, Clinical implant dentistry and related research.

[59]  P. Fielder,et al.  Implants: Bone physiology and metabolism. , 1987, CDA journal.

[60]  A B Carr,et al.  The response of bone in primates around unloaded dental implants supporting prostheses with different levels of fit. , 1996, The Journal of prosthetic dentistry.

[61]  R Puers,et al.  Magnitude and distribution of occlusal forces on oral implants supporting fixed prostheses: an in vivo study. , 2000, Clinical oral implants research.

[62]  N. Ferrigno,et al.  A long-term follow-up study of non-submerged ITI implants in the treatment of totally edentulous jaws. Part I: Ten-year life table analysis of a prospective multicenter study with 1286 implants. , 2002, Clinical oral implants research.

[63]  E S Rosenberg,et al.  Microbial differences in 2 clinically distinct types of failures of osseointegrated implants. , 1991, Clinical oral implants research.

[64]  D van Steenberghe,et al.  Fixture design and overload influence marginal bone loss and fixture success in the Brånemark system. , 1992, Clinical oral implants research.

[65]  B Prahl-Andersen,et al.  Human jaw muscle strength and size in relation to limb muscle strength and size. , 2004, European journal of oral sciences.

[66]  P. Fugazzotto A comparison of the success of root resected molars and molar position implants in function in a private practice: results of up to 15-plus years. , 2001, Journal of periodontology.

[67]  T. Diab,et al.  Age-dependent fatigue behaviour of human cortical bone. , 2005, European journal of morphology.

[68]  B Melsen,et al.  Biological reactions of alveolar bone to orthodontic loading of oral implants. , 2001, Clinical oral implants research.

[69]  S. Froum,et al.  Histologic evaluation of bone-implant contact of immediately loaded transitional implants after 6 to 27 months. , 2005, The International journal of oral & maxillofacial implants.

[70]  S. Bayne,et al.  Three-dimensional finite element analysis of stress-distribution around single tooth implants as a function of bony support, prosthesis type, and loading during function. , 1996, The Journal of prosthetic dentistry.

[71]  P. Nummikoski,et al.  A radiographic assessment of progressive loading on bone around single osseointegrated implants in the posterior maxilla. , 2005, Clinical oral implants research.

[72]  R. Mericske-Stern,et al.  Clinical evaluation and prosthetic complications of single tooth replacements by non-submerged implants. , 2001, Clinical oral implants research.

[73]  M. Quirynen,et al.  Periodontal aspects of osseointegrated fixtures supporting an overdenture. A 4-year retrospective study. , 1991, Journal of clinical periodontology.

[74]  J. Kent,et al.  Factors associated with soft- and hard-tissue compromise of endosseous implants. , 1990, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[75]  M. Esposito,et al.  Immunohistochemistry of soft tissues surrounding late failures of Brånemark implants. , 1997, Clinical oral implants research.

[76]  C. Han,et al.  A 1-year radiographic evaluation of marginal bone around dental implants. , 1996, The International journal of oral & maxillofacial implants.

[77]  R. Jaffin,et al.  The excessive loss of Branemark fixtures in type IV bone: a 5-year analysis. , 1991, Journal of periodontology.

[78]  O. Miyakawa,et al.  Influence of marginal bone resorption on stress around an implant--a three-dimensional finite element analysis. , 2005, Journal of oral rehabilitation.

[79]  J. Lindhe,et al.  Bone reactions to longstanding functional load at implants: an experimental study in dogs. , 2005, Journal of clinical periodontology.

[80]  G. Zarb,et al.  Immediate and early implant loading protocols: a literature review of clinical studies. , 2005, The Journal of prosthetic dentistry.

[81]  P J Becker,et al.  Survival of fixed implant-supported prostheses related to cantilever lengths. , 1994, The Journal of prosthetic dentistry.

[82]  D van Steenberghe,et al.  A study of 589 consecutive implants supporting complete fixed prostheses. Part II: Prosthetic aspects. , 1992, The Journal of prosthetic dentistry.

[83]  H. Frost,et al.  A 2003 update of bone physiology and Wolff's Law for clinicians. , 2009, The Angle orthodontist.

[84]  H. Frost,et al.  Perspectives: bone's mechanical usage windows. , 1992, Bone and mineral.

[85]  A. Scarano,et al.  Bone reactions to early occlusal loading of two-stage titanium plasma-sprayed implants: a pilot study in monkeys. , 1997, The International journal of periodontics & restorative dentistry.

[86]  C. Misch,et al.  A positive correlation between occlusal trauma and peri-implant bone loss: literature support. , 2005, Implant dentistry.

[87]  U. Lekholm,et al.  Implant treatment in edentulous maxillae: a 5-year follow-up report on patients with different degrees of jaw resorption. , 1995, The International journal of oral & maxillofacial implants.

[88]  N. Lang,et al.  The effect of subcrestal placement of the polished surface of ITI implants on marginal soft and hard tissues. , 1996, Clinical oral implants research.

[89]  F. Isidor,et al.  Loss of osseointegration caused by occlusal load of oral implants. A clinical and radiographic study in monkeys. , 1996, Clinical oral implants research.

[90]  Dirk Wiechmann,et al.  Load-related implant reaction of mini-implants used for orthodontic anchorage. , 2005, Clinical oral implants research.

[91]  D. Carter,et al.  Cyclic mechanical property degradation during fatigue loading of cortical bone. , 1996, Journal of biomechanics.

[92]  I Herrmann,et al.  A multicenter study of overdentures supported by Brånemark implants. , 1993, The International journal of oral & maxillofacial implants.

[93]  P. Kannus,et al.  Physical loading, exercise, and bone. , 1996, Bone.

[94]  P. Branemark,et al.  Osseointegrated implants in the treatment of the edentulous jaw. Experience from a 10-year period. , 1977, Scandinavian journal of plastic and reconstructive surgery. Supplementum.

[95]  G. Zarb,et al.  Bone level changes proximal to oral implants supporting fixed partial prostheses. , 2002, Clinical oral implants research.

[96]  Saadoun Ap,et al.  Clinical results and guidelines on Steri-Oss endosseous implants. , 1992 .

[97]  S. Sindet‐Pedersen,et al.  Outcome of treatment with implant-retained dental prostheses in patients with Sjögren syndrome. , 1999, The International journal of oral & maxillofacial implants.

[98]  U. Belser,et al.  Lack of integration of smooth titanium surfaces: a working hypothesis based on strains generated in the surrounding bone. , 1999, Clinical oral implants research.

[99]  C. Cobb,et al.  Comparison of peri-implant stresses transmitted by four commercially available osseointegrated implants. , 1989, The international journal of periodontics & restorative dentistry.

[100]  M R Rieger,et al.  Bone stress distribution for three endosseous implants. , 1989, The Journal of prosthetic dentistry.

[101]  G. Raghoebar,et al.  Maxillary bone grafting for insertion of endosseous implants: results after 12-124 months. , 2001, Clinical oral implants research.

[102]  L. Lanyon,et al.  Perspective: Postmenopausal Osteoporosis as a Failure of Bone's Adaptation to Functional Loading: A Hypothesis * , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[103]  L. Geris,et al.  The influence of micro-motion on the tissue differentiation around immediately loaded cylindrical turned titanium implants. , 2006, Archives of oral biology.

[104]  J. Malmqvist,et al.  Clinical report on the success of 47 consecutively placed Core-Vent implants followed from 3 months to 4 years. , 1990, The International journal of oral & maxillofacial implants.

[105]  Jean-Pierre Bernard,et al.  Implant stability measurement of delayed and immediately loaded implants during healing. , 2004, Clinical oral implants research.

[106]  T Vuillemin,et al.  Titanium implants and lateral forces. An experimental study with sheep. , 1997, Clinical oral implants research.

[107]  A. Carr,et al.  Reverse-torque failure of screw-shaped implants in baboons after 6 months of healing. , 1997, The International journal of oral & maxillofacial implants.

[108]  T Jemt,et al.  3-year followup study of early single implant restorations ad modum Brånemark. , 1990, The International journal of periodontics & restorative dentistry.

[109]  Nilgün Akin-Nergiza,et al.  Reactions of peri-implant tissues to continuous loading of osseointegrated implants. , 1998 .

[110]  A D Guckes,et al.  Prognostic variables associated with implant failure: a retrospective effectiveness study. , 1998, The International journal of oral & maxillofacial implants.

[111]  M. Ogiso,et al.  A histologic comparison of the functional loading capacity of an occluded dense apatite implant and the natural dentition. , 1994, The Journal of prosthetic dentistry.

[112]  N P Lang,et al.  Does excessive occlusal load affect osseointegration? An experimental study in the dog. , 2004, Clinical oral implants research.

[113]  D. Hungerford,et al.  Total knee arthroplasty in obese patients: a comparison with a matched control group. , 2004, The Journal of arthroplasty.

[114]  F. Isidor,et al.  Histological evaluation of peri-implant bone at implants subjected to occlusal overload or plaque accumulation. , 1997, Clinical oral implants research.

[115]  Z. Jaworski,et al.  Effect of long-term immobilisation on the pattern of bone loss in older dogs. , 1980, The Journal of bone and joint surgery. British volume.

[116]  M. Quirynen,et al.  Periodontal aspects of osseointegrated fixtures supporting a partial bridge. An up to 6-years retrospective study. , 1992, Journal of clinical periodontology.

[117]  L. Vrielinck,et al.  Three-year evaluation of Brånemark implants connected to angulated abutments. , 1997, The International journal of oral & maxillofacial implants.

[118]  M. Tonetti,et al.  Pathogenesis of implant failures. , 1994, Periodontology 2000.

[119]  K Gotfredsen,et al.  Bone reactions at implants subjected to experimental peri-implantitis and static load. A study in the dog. , 2002, Journal of clinical periodontology.

[120]  D van Steenberghe,et al.  Factors related to success and failure rates at 3-year follow-up in a multicenter study of overdentures supported by Brånemark implants. , 1995, The International journal of oral & maxillofacial implants.

[121]  L. Barbier,et al.  Adaptive bone remodeling around oral implants under axial and nonaxial loading conditions in the dog mandible. , 1997, The International journal of oral & maxillofacial implants.

[122]  R. Kohal,et al.  Changes in peri-implant tissues subjected to orthodontic forces and ligature breakdown in monkeys. , 1998, Journal of periodontology.

[123]  G. Carlsson,et al.  Influence of occlusal factors on treatment outcome: a study of 109 consecutive patients with mandibular implant-supported fixed prostheses opposing maxillary complete dentures. , 2001, The International journal of prosthodontics.

[124]  J. Hirsch,et al.  Biological factors contributing to failures of osseointegrated oral implants. (II). Etiopathogenesis. , 1998, European journal of oral sciences.

[125]  J. Lindhe,et al.  Bone reactions adjacent to titanium implants with different surface characteristics subjected to static load. A study in the dog (II). , 2001, Clinical oral implants research.

[126]  C Foitzik,et al.  Short (6-mm) nonsubmerged dental implants: results of a Multicenter clinical trial of 1 to 7 years. , 1998, The International journal of oral & maxillofacial implants.

[127]  K. Søballe,et al.  Revision of the uncemented hip prosthesis. , 1987, Acta orthopaedica Scandinavica.

[128]  Marc Quirynen,et al.  Infectious risks for oral implants: a review of the literature. , 2002, Clinical oral implants research.

[129]  J. Hirsch,et al.  Biological factors contributing to failures of osseointegrated oral implants. (I). Success criteria and epidemiology. , 1998, European journal of oral sciences.

[130]  W L Hylander,et al.  Elastic properties and masticatory bone stress in the macaque mandible. , 2000, American journal of physical anthropology.