Does metoclopramide exposure alter endometrial receptivity and decrease pregnancy rates?

Abstract Objective: The aim of this study was to investigate the effect of metoclopramide on endometrial receptivity with an immunohistochemical investigation of integrin β3 expression in pregnant rats. Materials and methods: In the present study, the pregnant mice administrated by different doses of metoclopramide were used to explore the effect of metoclopramide on embryo implantation, especially on the endometrial receptivity. Results: The statistical results showed that the number of implanted embryos was gradually declining along the increasing dose of metoclopramide. When the administrated dose of metoclopramide was 3 mg/kg per day, great changes were observed in the exposed uterine morphology and down-regulated integrin β3 were also found in high dose metoclopramide-exposed mice. Conclusion: Metoclopramide exposure, especially in high doses may alter endometrial receptivity by effecting integrin expression on decidual tissue which can decrease pregnancy rates. This drug should only be recommended for use during pregnancy when benefit outweighs the risk.

[1]  Ricardo Simoes,et al.  Systematic review of cell adhesion molecules and estrogen receptor expression in the endometrium of patients with polycystic ovary syndrome , 2015, International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.

[2]  Yanglu Liu,et al.  Sophoricoside fails the embryo implantation by compromising the uterine endometrial receptivity at implantation "window" of pregnant mice. , 2014, Chemico-biological interactions.

[3]  T. Fait,et al.  The most valuable predictorsof endometrial receptivity. , 2014, Ceska gynekologie.

[4]  R. Savaris,et al.  Endometrial beta3 Integrin profile reflects endometrial receptivity defects in women with unexplained recurrent pregnancy loss , 2014, Reproductive Biology and Endocrinology.

[5]  N. Vrachnis,et al.  Fetal outcomes associated with metoclopramide use in pregnancy. , 2014, JAMA.

[6]  D. Tesfaye,et al.  Oviductal, endometrial and embryonic gene expression patterns as molecular clues for pregnancy establishment. , 2012, Animal reproduction science.

[7]  S. Hernández-Díaz,et al.  Medications used to treat nausea and vomiting of pregnancy and the risk of selected birth defects. , 2012, Birth defects research. Part A, Clinical and molecular teratology.

[8]  L. Chen,et al.  Treatment with low-dose aspirin increased the level LIF and integrin β3 expression in mice during the implantation window. , 2010, Placenta.

[9]  V. Goossens,et al.  Assisted reproductive technology in Europe, 2006: results generated from European registers by ESHRE. , 2010, Human reproduction.

[10]  Harmeet Singh,et al.  Adhesion molecules in endometrial epithelium: tissue integrity and embryo implantation , 2009, Journal of anatomy.

[11]  V. Goossens,et al.  Assisted reproductive technology in Europe, 2004: results generated from European registers by ESHRE. , 2008, Human reproduction.

[12]  M. Festin.  Nausea and vomiting in early pregnancy. , 2015, BMJ clinical evidence.

[13]  A. Revel,et al.  Endometrial receptivity markers, the journey to successful embryo implantation. , 2006, Human reproduction update.

[14]  B. Lessey.  Implantation Defects in Infertile Women with Endometriosis , 2002, Annals of the New York Academy of Sciences.

[15]  S. Dey,et al.  Molecular signaling in uterine receptivity for implantation. , 2000, Seminars in cell & developmental biology.

[16]  Y. Lei,et al.  Further characterization of endometrial integrins during the menstrual cycle and in pregnancy. , 1994, Fertility and sterility.

[17]  Christos Coutifaris,et al.  Integrin adhesion molecules in the human endometrium. Correlation with the normal and abnormal menstrual cycle. , 1992, The Journal of clinical investigation.