Treating pediatric port‐wine stains without general anesthesia

Dear Editors, Port-wine stains (PWS) are the most common congenital malformation of ectatic capillaries and postcapillary venules, causing a reddish-purplish discoloration of the skin. Gold standard of therapy is the pulsed-dye laser (PDL) treatment, which selectively targets hemoglobin, thereby destroying the capillary malformation. As a result, lesions are lightenedand theprogression to irregular anddarkened stains with a nodular surface can be prevented. In addition to the location and size of PWS, an early patient age is the major determinant of PDL treatment success, which obviously relates to the thinner skin of young children.1 It might be assumed that the amount of hemoglobin being present in the small vessels of infants might be not quite sufficient for PDL treatment, but in fact younger patients frequently showbetter response than older ones.2 Jeon et al.,3 and Chapas et al.,4 have shown that PDL treatment is effective in infants of 1 year and even 6 months of age or less, respectively. Several studies have demonstrated the psychosocial PWS impacts such as stigmatization and reduced health-related quality of life, but there is still no validated outcome measure instrument to evaluate the clinical outcome of PWS treatments.5 However, early treatment can obviously avoid psychosocial impairments in paediatric PWS patients caused by progressing disfigurements and adaptation problems towards the social environment. To this end, Jiang et al. showed that both the age of the patient and PWS classification correlated positively with the Children’s Dermatology Life Index score, indicating that children’s QoL was more affected as they got older or the color of the skin lesions darkened.6 A decisive factor in favor of early treatment is the objective of minimizing the psychosocial stress which could

[1]  Zhiming Li,et al.  Influence of Port-wine Stains on Quality of Life of Children and Their Parents , 2021, Acta dermato-venereologica.

[2]  T. Jantarakolica,et al.  Quality of Life and Psychological Effects of Port-Wine Stain: A Review of Literature , 2021, Clinical, cosmetic and investigational dermatology.

[3]  G. Storm,et al.  Treatment Outcome Measurement Instruments for Port Wine Stains: A Systematic Review of Their Measurement Properties , 2020, Dermatology.

[4]  R. Geronemus,et al.  Pulsed Dye Laser Treatment of Port-Wine Stains in Infancy Without the Need for General Anesthesia , 2019, JAMA dermatology.

[5]  D. Andropoulos,et al.  Anesthesia and Developing Brains—Implications of the FDA Warning , 2017 .

[6]  J. Koo,et al.  Risk of systemic toxicity with topical lidocaine/prilocaine: a review. , 2014, Journal of drugs in dermatology : JDD.

[7]  R. Geronemus,et al.  Efficacy of early treatment of facial port wine stains in newborns: A review of 49 cases , 2007, Lasers in surgery and medicine.

[8]  M. Augustin,et al.  Psychosocial Stress of Patients with Port Wine Stains and Expectations of Dye Laser Treatment , 1998, Dermatology.

[9]  Huff,et al.  Facial port wine stains in childhood: prediction of the rate of improvement as a function of the age of the patient, size and location of the port wine stain and the number of treatments with the pulsed dye (585 nm) laser , 1998, The British journal of dermatology.

[10]  R. Geronemus,et al.  Treatment of port-wine stains during childhood with the flashlamp-pumped pulsed dye laser. , 1990, Journal of the American Academy of Dermatology.