hvps34, an ancient player, enters a growing game: mTOR Complex1/S6K1 signaling.
暂无分享,去创建一个
[1] D. Guertin,et al. Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. , 2006, Developmental cell.
[2] Michele Pagano,et al. S6K1- and ßTRCP-Mediated Degradation of PDCD4 Promotes Protein Translation and Cell Growth , 2006, Science.
[3] Jacob D. Jaffe,et al. mSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s , 2006, Current Biology.
[4] M. Thumm,et al. The relevance of the phosphatidylinositolphosphat‐binding motif FRRGT of Atg18 and Atg21 for the Cvt pathway and autophagy , 2006, FEBS letters.
[5] Peter Novick,et al. Rabs and their effectors: Achieving specificity in membrane traffic , 2006, Proceedings of the National Academy of Sciences.
[6] G. Kroemer,et al. Current development of mTOR inhibitors as anticancer agents , 2006, Nature Reviews Drug Discovery.
[7] B. Oh,et al. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG , 2006, Nature Cell Biology.
[8] V. Stambolic,et al. Localization of Rheb to the endomembrane is critical for its signaling function. , 2006, Biochemical and biophysical research communications.
[9] G. Thomas,et al. Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1. , 2006, Cell metabolism.
[10] B. Kahn,et al. mTOR tells the brain that the body is hungry , 2006, Nature Medicine.
[11] G. Thomas,et al. The amino acid sensitive TOR pathway from yeast to mammals , 2006, FEBS letters.
[12] M. Hall,et al. TOR Signaling in Growth and Metabolism , 2006, Cell.
[13] F. Natt,et al. Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[14] Michael D. Schneider,et al. Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy , 2005, Cell.
[15] James T. Murray,et al. hVps34 Is a Nutrient-regulated Lipid Kinase Required for Activation of p70 S6 Kinase* , 2005, Journal of Biological Chemistry.
[16] Yuval Dor,et al. Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis. , 2005, Genes & development.
[17] C. Johannessen,et al. Regulation of mTOR and Cell Growth in Response to Energy Stress by REDD1 , 2005, Molecular and Cellular Biology.
[18] M. Krebs. Amino acid‐dependent modulation of glucose metabolism in humans , 2005, European journal of clinical investigation.
[19] C. Proud,et al. The Tuberous Sclerosis Protein TSC2 Is Not Required for the Regulation of the Mammalian Target of Rapamycin by Amino Acids and Certain Cellular Stresses* , 2005, Journal of Biological Chemistry.
[20] Joseph Avruch,et al. Rheb Binds and Regulates the mTOR Kinase , 2005, Current Biology.
[21] Alfred Nordheim,et al. WIPI-1α (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy , 2004, Oncogene.
[22] R. Loewith,et al. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive , 2004, Nature Cell Biology.
[23] G. Thomas,et al. Disruption of the Mouse mTOR Gene Leads to Early Postimplantation Lethality and Prohibits Embryonic Stem Cell Development , 2004, Molecular and Cellular Biology.
[24] L. Pelkmans,et al. Not just a sink: endosomes in control of signal transduction. , 2004, Current opinion in cell biology.
[25] A. Gingras,et al. Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases , 2004, The EMBO journal.
[26] Jean Gruenberg,et al. The biogenesis of multivesicular endosomes , 2004, Nature Reviews Molecular Cell Biology.
[27] S. Kimball,et al. Molecular mechanisms through which amino acids mediate signaling through the mammalian target of rapamycin , 2004, Current opinion in clinical nutrition and metabolic care.
[28] Govind Bhagat,et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. , 2003, The Journal of clinical investigation.
[29] Arnold J. Levine,et al. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[30] K. Inoki,et al. TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival , 2003, Cell.
[31] B. Edgar,et al. Rheb promotes cell growth as a component of the insulin/TOR signalling network , 2003, Nature Cell Biology.
[32] B. Edgar,et al. Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins , 2003, Nature Cell Biology.
[33] E. Hafen,et al. Rheb is an essential regulator of S6K in controlling cell growth in Drosophila , 2003, Nature Cell Biology.
[34] E. Hafen,et al. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. , 2003, Molecular cell.
[35] J. Blenis,et al. TOS Motif-Mediated Raptor Binding Regulates 4E-BP1 Multisite Phosphorylation and Function , 2003, Current Biology.
[36] M. Lemmon,et al. Phosphoinositide Recognition Domains , 2003, Traffic.
[37] Paul Tempst,et al. GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. , 2003, Molecular cell.
[38] K. Inoki,et al. Regulation of TSC2 by 14-3-3 Binding* , 2002, The Journal of Biological Chemistry.
[39] A. Hodges,et al. Tuberous sclerosis complex tumor suppressor–mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent , 2002, The Journal of cell biology.
[40] A. V. D. van den Ouweland,et al. Identification and Characterization of the Interaction between Tuberin and 14-3-3ζ* , 2002, The Journal of Biological Chemistry.
[41] G. Thomas,et al. Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling. , 2002, Genes & development.
[42] J. Crespo,et al. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. , 2002, Molecular cell.
[43] K. Inoki,et al. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling , 2002, Nature Cell Biology.
[44] D. Sabatini,et al. mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery , 2002, Cell.
[45] J. Avruch,et al. Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action , 2002, Cell.
[46] J. Blenis,et al. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. , 2002, Molecular cell.
[47] Harald Stenmark,et al. Role of Rab5 in the Recruitment of hVps34/p150 to the Early Endosome , 2002, Traffic.
[48] A. Jaeschke,et al. Mammalian TOR: A Homeostatic ATP Sensor , 2001, Science.
[49] K Suzuki,et al. The pre‐autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation , 2001, The EMBO journal.
[50] G. Thomas,et al. Insulin Signaling: Lessons from the Drosophila Tuberous Sclerosis Complex, a Tumor Suppressor , 2001, Science's STKE.
[51] C. Proud,et al. Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase , 2001, The EMBO journal.
[52] Y. Ohsumi,et al. Beclin–phosphatidylinositol 3‐kinase complex functions at the trans‐Golgi network , 2001, EMBO reports.
[53] S. Emr,et al. Autophagy as a regulated pathway of cellular degradation. , 2000, Science.
[54] M. Zerial,et al. Phosphatidylinositol-3-OH kinases are Rab5 effectors , 1999, Nature Cell Biology.
[55] P. Houghton,et al. Amino acid-dependent control of p70(s6k). Involvement of tRNA aminoacylation in the regulation. , 1999, The Journal of biological chemistry.
[56] James E. Goldman,et al. Protection against Fatal Sindbis Virus Encephalitis by Beclin, a Novel Bcl-2-Interacting Protein , 1998, Journal of Virology.
[57] M. Mcdaniel,et al. Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic beta-cells. A possible role in protein translation and mitogenic signaling. , 1998, The Journal of biological chemistry.
[58] Marino Zerial,et al. EEA1 links PI(3)K function to Rab5 regulation of endosome fusion , 1998, Nature.
[59] J. Avruch,et al. Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism* , 1998, The Journal of Biological Chemistry.
[60] F. McCormick,et al. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. , 1997, Science.
[61] P. Cohen,et al. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα , 1997, Current Biology.
[62] M. Waterfield,et al. Characterization of p150, an Adaptor Protein for the Human Phosphatidylinositol (PtdIns) 3-Kinase , 1997, The Journal of Biological Chemistry.
[63] T. Smith,et al. Analysis of the physical properties and molecular modeling of Sec13: A WD repeat protein involved in vesicular traffic. , 1996, Biochemistry.
[64] Y. Fukui,et al. Synergistic effect of alanine and glycine on bovine embryos cultured in a chemically defined medium and amino acid uptake by vitro-produced bovine morulae and blastocysts. , 1996, Biology of reproduction.
[65] M. Zvelebil,et al. A human phosphatidylinositol 3‐kinase complex related to the yeast Vps34p‐Vps15p protein sorting system. , 1995, The EMBO journal.
[66] A. Meijer,et al. Phosphorylation of Ribosomal Protein S6 Is Inhibitory for Autophagy in Isolated Rat Hepatocytes (*) , 1995, The Journal of Biological Chemistry.
[67] C. Barnes,et al. rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein. , 1994, The Journal of biological chemistry.
[68] J. Thorner,et al. Phosphatidylinositol 4-kinase: gene structure and requirement for yeast cell viability. , 1993, Science.
[69] S. Emr,et al. A membrane‐associated complex containing the Vps15 protein kinase and the Vps34 PI 3‐kinase is essential for protein sorting to the yeast lysosome‐like vacuole. , 1993, The EMBO journal.
[70] K. Takegawa,et al. Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. , 1993, Science.
[71] S. Emr,et al. Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae , 1990, Molecular and cellular biology.
[72] Y. Nishizuka,et al. The molecular heterogeneity of protein kinase C and its implications for cellular regulation , 1988, Nature.
[73] B. Wolf,et al. Leucine regulation of glucokinase and ATP synthase sensitizes glucose-induced insulin secretion in pancreatic beta-cells. , 2006, Diabetes.