The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth

[1]  D. Small,et al.  A protease activity associated with acetylcholinesterase releases the membrane-bound form of the amyloid protein precursor of Alzheimer's disease. , 1991, Biochemistry.

[2]  Walter Schubert,et al.  Localization of Alzheimer βA4 amyloid precursor protein at central and peripheral synaptic sites , 1991, Brain Research.

[3]  K. Murakami,et al.  Formation of β-amyloid protein deposits in brains of transgenic mice , 1991, Nature.

[4]  B. Greenberg,et al.  High affinity interactions between the Alzheimer's beta-amyloid precursor proteins and the basement membrane form of heparan sulfate proteoglycan. , 1991, The Journal of biological chemistry.

[5]  P. Brachet,et al.  Nerve growth factor-induced neuronal differentiation is accompanied by differential splicing of beta-amyloid precursor mRNAs in the PC12 cell line. , 1991, Brain research. Molecular brain research.

[6]  Michael Alford,et al.  Patterns of aberrant sprouting in alzheimer's disease , 1991, Neuron.

[7]  B. Yankner,et al.  An antibody to β amyloid and the amyloid precursor protein inhibits cell-substratum adhesion in many mammalian cell types , 1991, Neuroscience Letters.

[8]  C. Masters,et al.  Alternative splicing of the βA4 amyloid gene of Alzheimer's disease in cortex of control and Alzheimer's disease patients , 1991 .

[9]  B. Anderton,et al.  Beta amyloid precursor protein mediates neuronal cell‐cell and cell‐surface adhesion , 1991, Journal of neuroscience research.

[10]  B. Yankner,et al.  Nerve growth factor potentiates the neurotoxicity of beta amyloid. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[11]  D. Kirschner,et al.  Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. , 1990, Science.

[12]  C. Masters,et al.  Retinoic acid induced differentiated neuroblastoma cells show increased expression of the βA4 amyloid gene of Alzheimer's disease and an altered splicing pattern , 1990, FEBS letters.

[13]  R. Neve,et al.  The Alzheimer amyloid precursor-related transcript lacking the β/A4 sequence is specifically increased in Alzheimer's disease brain , 1990, Neuron.

[14]  T. Oltersdorf,et al.  Cleavage of amyloid beta peptide during constitutive processing of its precursor. , 1990, Science.

[15]  C. Finch,et al.  Relation of neuronal APP-751/APP-695 mRNA ratio and neuritic plaque density in Alzheimer's disease. , 1990, Science.

[16]  G. Cole,et al.  Amyloid β-protein precursor is associated with extracellular matrix , 1990, Brain Research.

[17]  D. Price,et al.  Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing. , 1990, Science.

[18]  C. Cotman,et al.  β-Amyloid protein promotes neuritic branching in hippocampal cultures , 1990, Neuroscience Letters.

[19]  R. Catalano,et al.  Fibroblast growth factor induces beta-amyloid precursor mRNA in glial but not neuronal cultured cells. , 1990, Biochemical and biophysical research communications.

[20]  S. Younkin,et al.  Expression of β amyloid protein precursor mRNAs: Recognition of a novel alternatively spliced form and quantitation in alzheimer's disease using PCR , 1990, Neuron.

[21]  G. Cole,et al.  The regulation of amyloid β protein precursor secretion and its modulatory role in cell adhesion , 1989, Neuron.

[22]  S. Younkin,et al.  Soluble derivatives of the β amyloid protein precursor of Alzheimer's disease are labeled by antisera to the β amyloid protein , 1989 .

[23]  S. Hunt,et al.  Expression and cellular localization of amyloid β-protein precursor transcripts in normal human brain and in Alzheimer's disease , 1989 .

[24]  K. Kosik,et al.  Microtubular reorganization and dendritic growth response in alzheimer's disease , 1989, Annals of neurology.

[25]  N. Robakis,et al.  Nerve and epidermal growth factors induce the release of the Alzheimer amyloid precursor from PC 12 cell cultures. , 1989, Biochemical and biophysical research communications.

[26]  Carl W. Cotman,et al.  Protease nexin-II, a potent anti-chymotrypsin, shows identity to amyloid β-protein precursor , 1989, Nature.

[27]  K. Johnson-wood,et al.  The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II , 1989, Nature.

[28]  T. Oltersdorf,et al.  Secreted form of amyloid β protein precursor is involved in the growth regulation of fibroblasts , 1989, Cell.

[29]  F. D. de Sauvage,et al.  A novel mRNA of the A4 amyloid precursor gene coding for a possibly secreted protein. , 1989, Science.

[30]  D. Selkoe,et al.  The beta-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[31]  L. Villa-komaroff,et al.  Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. , 1989, Science.

[32]  G. Cole,et al.  Amyloid beta protein precursor is a mitogen. , 1989, Biochemical and biophysical research communications.

[33]  R. Martins,et al.  Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease. , 1989, The New England journal of medicine.

[34]  Steven A. Johnson,et al.  APP-695 transcript prevalence is selectively reduced during Alzheimer's disease in cortex and hippocampus but not in cerebellum , 1989, Neurobiology of Aging.

[35]  Andreas Weidemann,et al.  Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein , 1989, Cell.

[36]  C. Cotman,et al.  Amyloid beta protein enhances the survival of hippocampal neurons in vitro. , 1989, Science.

[37]  G. Cole,et al.  Characterization of an amyloid beta precursor protein that binds heparin and contains tyrosine sulfate. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[38]  D. Monard Cell-derived proteases and protease inhibitors as regulators of neurite outgrowth , 1988, Trends in Neurosciences.

[39]  P. Brachet,et al.  Messenger RNAs of β-amyloid precursor protein and prion protein are regulated by nerve growth factor in PC12 cells , 1988, International Journal of Developmental Neuroscience.

[40]  S. Prusiner,et al.  Nerve growth factor increases mRNA levels for the prion protein and the beta-amyloid protein precursor in developing hamster brain. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[41]  R. Neve,et al.  Expression of the Alzheimer amyloid precursor gene transcripts in the human brain , 1988, Neuron.

[42]  D. Selkoe,et al.  Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[43]  K. Beyreuther,et al.  The promoter of Alzheimer's disease amyloid A4 precursor gene. , 1988, Progress in clinical and biological research.

[44]  Y. Ihara Massive somatodendritic sprouting of cortical neurons in Alzheimer's disease , 1988, Brain Research.

[45]  R. Tanzi,et al.  Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease. , 1988, Science.

[46]  S. Shiojiri,et al.  Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity , 1988, Nature.

[47]  L. Villa-komaroff,et al.  Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease , 1988, Nature.

[48]  B. Greenberg,et al.  A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors , 1988, Nature.

[49]  S. Younkin,et al.  In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[50]  H. Wiśniewski,et al.  Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[51]  P. S. St George-Hyslop,et al.  Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. , 1987, Science.

[52]  K. Grzeschik,et al.  The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor , 1987, Nature.

[53]  C. Cotman,et al.  Senile plaques as aberrant sprout-stimulating structures , 1986, Experimental Neurology.

[54]  M. Greenberg,et al.  Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells. , 1985, The Journal of biological chemistry.

[55]  I. Verma,et al.  Induction of the proto-oncogene fos by nerve growth factor. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[56]  R. Martins,et al.  Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels. , 1985, The EMBO journal.

[57]  T. Curran,et al.  Superinduction of c-fos by nerve growth factor in the presence of peripherally active benzodiazepines. , 1985, Science.

[58]  Bertram Wiedenmann,et al.  Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles , 1985, Cell.

[59]  T. Katsouleas,et al.  Ultrahigh gradient particle acceleration by intense laser-driven plasma density waves , 1984, Nature.

[60]  G. Glenner,et al.  Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein , 1984 .

[61]  D. Schubert NGF-induced alternations in protein secretion and substrate-attached material of a clonal nerve cell line , 1978, Brain Research.

[62]  L. Greene,et al.  Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. , 1976, Proceedings of the National Academy of Sciences of the United States of America.

[63]  P C Letourneau,et al.  Cell-to-substratum adhesion and guidance of axonal elongation. , 1975, Developmental biology.