Rice Consumption and Urinary Arsenic Concentrations in U.S. Children

BACKGROUND In adult populations, emerging evidence indicates that humans are exposed to arsenic by ingestion of contaminated foods such as rice, grains, and juice; yet little is known about arsenic exposure among children. OBJECTIVES Our goal was to determine whether rice consumption contributes to arsenic exposure in U.S. children. METHODS We used data from the nationally representative National Health and Nutrition Examination Survey (NHANES) to examine the relationship between rice consumption (measured in 0.25 cups of cooked rice per day) over a 24-hr period and subsequent urinary arsenic concentration among the 2,323 children (6-17 years of age) who participated in NHANES from 2003 to 2008. We examined total urinary arsenic (excluding arsenobetaine and arsenocholine) and dimethylarsinic acid (DMA) concentrations overall and by age group: 6-11 years and 12-17 years. RESULTS The median [interquartile range (IQR)] total urinary arsenic concentration among children who reported consuming rice was 8.9 μg/L (IQR: 5.3-15.6) compared with 5.5 μg/L (IQR: 3.1-8.4) among those who did not consume rice. After adjusting for potentially confounding factors, and restricting the study to participants who did not consume seafood in the preceding 24 hr, total urinary arsenic concentration increased 14.2% (95% confidence interval: 11.3, 17.1%) with each 0.25 cup increase in cooked rice consumption. CONCLUSIONS Our study suggests that rice consumption is a potential source of arsenic exposure in U.S. children.

[1]  K. L. Cottingham,et al.  Arsenic, Organic Foods, and Brown Rice Syrup , 2012, Environmental health perspectives.

[2]  S. Pinson,et al.  Variation in grain arsenic assessed in a diverse panel of rice (Oryza sativa) grown in multiple sites. , 2012, The New phytologist.

[3]  N. Malats,et al.  Pancreatic cancer risk and levels of trace elements , 2011, Gut.

[4]  Margaret R Karagas,et al.  Rice consumption contributes to arsenic exposure in US women , 2011, Proceedings of the National Academy of Sciences.

[5]  M. Bottai,et al.  Critical windows of exposure for arsenic-associated impairment of cognitive function in pre-school girls and boys: a population-based cohort study. , 2011, International journal of epidemiology.

[6]  J. Domingo,et al.  Human Exposure to Arsenic, Cadmium, Mercury, and Lead from Foods in Catalonia, Spain: Temporal Trend , 2011, Biological Trace Element Research.

[7]  S. Santra,et al.  Human exposure to arsenic through foodstuffs cultivated using arsenic contaminated groundwater in areas of West Bengal, India. , 2011, Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering.

[8]  Fernando Barbosa,et al.  Speciation of arsenic in rice and estimation of daily intake of different arsenic species by Brazilians through rice consumption. , 2011, Journal of hazardous materials.

[9]  J. Ludvigsson,et al.  Clinical management of coeliac disease , 2011, Journal of internal medicine.

[10]  P. Grandjean,et al.  Cancer excess after arsenic exposure from contaminated milk powder , 2011, Environmental health and preventive medicine.

[11]  D. Silverman,et al.  Estimating Water Supply Arsenic Levels in the New England Bladder Cancer Study , 2011, Environmental health perspectives.

[12]  A. Sharrett,et al.  Urine Arsenic and Hypertension in US Adults: The 2003–2008 National Health and Nutrition Examination Survey , 2011, Epidemiology.

[13]  P. Haris,et al.  The impact of a rice based diet on urinary arsenic. , 2011, Journal of environmental monitoring : JEM.

[14]  M. Vahter,et al.  Arsenic Exposure in Pregnancy Increases the Risk of Lower Respiratory Tract Infection and Diarrhea during Infancy in Bangladesh , 2010, Environmental health perspectives.

[15]  M. Vahter,et al.  Arsenic Exposure and Risk of Spontaneous Abortion, Stillbirth, and Infant Mortality , 2010, Epidemiology.

[16]  M. J. Galotto,et al.  Determination of Dietary Intake of Total Arsenic, Inorganic Arsenic and Total Mercury in the Chilean School Meal Program , 2010, Food science and technology international = Ciencia y tecnologia de los alimentos internacional.

[17]  Yan Zheng,et al.  Assessment of in vivo bioaccessibility of arsenic in dietary rice by a mass balance approach. , 2010, Science of the Total Environment.

[18]  K. Orloff,et al.  Biomonitoring for Environmental Exposures to Arsenic , 2009, Journal of toxicology and environmental health. Part B, Critical reviews.

[19]  Nazmul Sohel,et al.  Arsenic in Drinking Water and Adult Mortality: A Population-based Cohort Study in Rural Bangladesh , 2009, Epidemiology.

[20]  Jane Liaw,et al.  Low-level Population Exposure to Inorganic Arsenic in the United States and Diabetes Mellitus: A Reanalysis , 2009, Epidemiology.

[21]  Julie Upton,et al.  Rice consumption in the United States: recent evidence from food consumption surveys. , 2009, Journal of the American Dietetic Association.

[22]  J. Schwartz,et al.  Maternal Arsenic Exposure and Impaired Glucose Tolerance during Pregnancy , 2009, Environmental health perspectives.

[23]  Yong-guan Zhu,et al.  Geographical variation in total and inorganic arsenic content of polished (white) rice. , 2009, Environmental science & technology.

[24]  S. Tanabe,et al.  Relationship of urinary arsenic metabolites to intake estimates in residents of the Red River Delta, Vietnam. , 2009, Environmental pollution.

[25]  V. Slavkovich,et al.  Folate, Cobalamin, Cysteine, Homocysteine, and Arsenic Metabolism among Children in Bangladesh , 2009, Environmental health perspectives.

[26]  E. Faustman,et al.  Arsenic Exposure within the Korean Community (United States) Based on Dietary Behavior and Arsenic Levels in Hair, Urine, Air, and Water , 2008, Environmental health perspectives.

[27]  Mohammed Yunus,et al.  Arsenic exposure during pregnancy and size at birth: a prospective cohort study in Bangladesh. , 2008, American journal of epidemiology.

[28]  Ellen K Silbergeld,et al.  Arsenic exposure and prevalence of type 2 diabetes in US adults. , 2008, JAMA.

[29]  C. Ferreccio,et al.  Increased Childhood Liver Cancer Mortality and Arsenic in Drinking Water in Northern Chile , 2008, Cancer Epidemiology Biomarkers & Prevention.

[30]  D. Baer,et al.  The US Department of Agriculture Automated Multiple-Pass Method reduces bias in the collection of energy intakes. , 2008, The American journal of clinical nutrition.

[31]  S. McGrath,et al.  Transporters of arsenite in rice and their role in arsenic accumulation in rice grain , 2008, Proceedings of the National Academy of Sciences.

[32]  M. Vahter.  Health effects of early life exposure to arsenic. , 2008, Basic & clinical pharmacology & toxicology.

[33]  N. Skovgaard.  Safety evaluation of certain contaminants in food , 2007 .

[34]  J. Feldmann,et al.  Market basket survey shows elevated levels of As in South Central U.S. processed rice compared to California: consequences for human dietary exposure. , 2007, Environmental science & technology.

[35]  B. Eskenazi,et al.  Children's Intellectual Function in Relation to Arsenic Exposure , 2007, Epidemiology.

[36]  F. Parvez,et al.  Water Arsenic Exposure and Intellectual Function in 6-Year-Old Children in Araihazar, Bangladesh , 2006, Environmental health perspectives.

[37]  Steve Selvin,et al.  Increased Mortality from Lung Cancer and Bronchiectasis in Young Adults after Exposure to Arsenic in Utero and in Early Childhood , 2006, Environmental health perspectives.

[38]  Richard Goldstein,et al.  Regression Methods in Biostatistics: Linear, Logistic, Survival and Repeated Measures Models , 2006, Technometrics.

[39]  J Feldmann,et al.  Variation in arsenic speciation and concentration in paddy rice related to dietary exposure. , 2005, Environmental science & technology.

[40]  Y. Hsueh,et al.  Ingested arsenic, cigarette smoking, and lung cancer risk: a follow-up study in arseniasis-endemic areas in Taiwan. , 2004, JAMA.

[41]  Samuel P. Caudill,et al.  Urinary Creatinine Concentrations in the U.S. Population: Implications for Urinary Biologic Monitoring Measurements , 2004, Environmental health perspectives.

[42]  L. Barraj,et al.  Estimation of Dietary Intake of Inorganic Arsenic in U.S. Children , 2004 .

[43]  Margaret R. Karagas,et al.  Incidence of Transitional Cell Carcinoma of the Bladder and Arsenic Exposure in New Hampshire , 2004, Cancer Causes & Control.

[44]  F. Parvez,et al.  Water Arsenic Exposure and Children’s Intellectual Function in Araihazar, Bangladesh , 2004, Environmental health perspectives.

[45]  Chien-Jen Chen,et al.  The effects of chronic arsenic exposure from drinking water on the neurobehavioral development in adolescence. , 2003, Neurotoxicology.

[46]  D. Menzel,et al.  Estimation of Multimedia Inorganic Arsenic Intake in the U.S. Population , 2002 .

[47]  Prosun Bhattacharya,et al.  Arsenic in Groundwater of the Bengal Delta Plain Aquifers in Bangladesh , 2002, Bulletin of environmental contamination and toxicology.

[48]  T. Tosteson,et al.  Skin cancer risk in relation to toenail arsenic concentrations in a US population-based case-control study. , 2001, American journal of epidemiology.

[49]  T. Tosteson,et al.  Measurement of low levels of arsenic exposure: a comparison of water and toenail concentrations. , 2000, American journal of epidemiology.

[50]  X. Le,et al.  Effect of arsenosugar ingestion on urinary arsenic speciation. , 1998, Clinical chemistry.

[51]  J. Edmonds,et al.  Arsenic in seafoods: Human health aspects and regulations , 1993 .

[52]  K. Reimer,et al.  Arsenic speciation in the environment , 1989 .

[53]  H. Meltzer,et al.  Humans seem to produce arsenobetaine and dimethylarsinate after a bolus dose of seafood. , 2012, Environmental research.

[54]  F. Parvez,et al.  Arsenic and manganese exposure and children's intellectual function. , 2011, Neurotoxicology.

[55]  E. Guallar,et al.  Seafood intake and urine concentrations of total arsenic, dimethylarsinate and arsenobetaine in the US population. , 2011, Environmental research.

[56]  Shi V Liu,et al.  Probabilistic Modeling of Dietary Arsenic Exposure and Dose and Evaluation with 2003–2004 NHANES Data , 2009, Environmental health perspectives.

[57]  Robert L. Jones,et al.  Levels of urinary total and speciated arsenic in the US population: National Health and Nutrition Examination Survey 2003–2004 , 2009, Journal of Exposure Science and Environmental Epidemiology.

[58]  H. Aposhian,et al.  Arsenic toxicology: five questions. , 2006, Chemical research in toxicology.

[59]  T. Gebel.  Arsenic methylation is a process of detoxification through accelerated excretion. , 2002, International journal of hygiene and environmental health.