Cholecystokinin in the brains of obese and nonobese mice.

Extracts of the cerebral cortes of genetically obese (ob/ob) mice with hyperphagia contain 0.05 +/- 0.02 microgram (mean +/- standard error) of cholecystokinin octapeptide equivalent per gram of wet weight compared to 0.15 +/- 0.01 microgram per gram for their nonobese littermates and 0.20 +/- 0.01 microgram per gram for normal LAF1 mice. These findings are suggestive of a causal relation between the diminished brain immunoreactive cholecystokinin content and the unrestrained appetite of the obese mice.

[1]  S. Maddison.  Intraperitoneal and intracranial cholecystokinin depress operant responding for food , 1977, Physiology & Behavior.

[2]  R. Yalow,et al.  Cholecystokinin and its COOH-terminal octapeptide in the pig brain. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[3]  R. Yalow,et al.  Immunohistochemical localization in rabbit brain of a peptide resembling the COOH-terminal octapeptide of cholecystokinin. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[4]  J. Stern,et al.  Ventromedial hypothalamus and short-term feeding suppression by caerulein in male rats. , 1976, Journal of comparative and physiological psychology.

[5]  R. Young,et al.  Cholecystokinin elicits Satiety in Rats with Open Gastric Fistulas , 1973, Nature.

[6]  G. P. Smith,et al.  Cholecystokinin decreases food intake in rats. , 1973, Journal of comparative and physiological psychology.

[7]  A. Schally,et al.  Enterogastrone Inhibits Eating by Fasted Mice , 1967, Science.

[8]  R. Yalow,et al.  Species specificity of cholecystokinin in gut and brain of several mammalian species. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[9]  P. McHugh,et al.  Cholecystokinin-decreased food intake in rhesus monkeys. , 1976, The American journal of physiology.