Site-directed mutagenesis reveals a unique requirement for tyrosine residues in IL-7Rα and TSLPR cytoplasmic domains in TSLP-dependent cell proliferation

[1]  W. Leonard,et al.  Thymic stromal lymphopoietin: a new cytokine in asthma. , 2008, Current opinion in pharmacology.

[2]  D. Teachey,et al.  Thymic stromal-derived lymphopoietin induces proliferation of pre-B leukemia and antagonizes mTOR inhibitors, suggesting a role for interleukin-7Ralpha signaling. , 2007, Cancer research.

[3]  D. Levy,et al.  The molecular basis of IL-21-mediated proliferation. , 2007, Blood.

[4]  Y. J. Liu,et al.  Thymic stromal lymphopoietin: A potential therapeutic target for allergy and asthma , 2006, Current allergy and asthma reports.

[5]  S. Ziegler,et al.  Absence of an Essential Role for Thymic Stromal Lymphopoietin Receptor in Murine B-Cell Development , 2004, Molecular and Cellular Biology.

[6]  S. Ziegler,et al.  Uncoupling of Proliferation and Stat5 Activation in Thymic Stromal Lymphopoietin-Mediated Signal Transduction1 , 2002, The Journal of Immunology.

[7]  H. Drexler,et al.  Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation , 2001, Leukemia.

[8]  R. de Waal Malefyt,et al.  Human Thymic Stromal Lymphopoietin Preferentially Stimulates Myeloid Cells1 , 2001, The Journal of Immunology.

[9]  D. Largaespada,et al.  Cloning of the Murine Thymic Stromal Lymphopoietin (Tslp) Receptor , 2000, The Journal of experimental medicine.

[10]  Heinz Baumann,et al.  Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin , 2000, Nature Immunology.

[11]  R. Weinberg,et al.  Generation of mammalian cells stably expressing multiple genes at predetermined levels. , 2000, Analytical biochemistry.

[12]  S. Ziegler,et al.  Requirement for stat5 in thymic stromal lymphopoietin-mediated signal transduction. , 1999, Journal of immunology.

[13]  H. Spits,et al.  Distinct roles of the phosphatidylinositol 3-kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors. , 1999, Immunity.

[14]  R. Perlmutter,et al.  Thymic stromal lymphopoietin: a cytokine that promotes the development of IgM+ B cells in vitro and signals via a novel mechanism. , 1999, Journal of immunology.

[15]  S. Ziegler,et al.  Requirement for Stat 5 in Thymic Stromal Lymphopoietin-Mediated Signal Transduction 1 , 1999 .

[16]  J. Renauld,et al.  A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9 , 1996, Molecular and cellular biology.

[17]  M. Owen,et al.  The interleukin‐7 receptor alpha chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis. , 1996, The EMBO journal.

[18]  M. Goldsmith,et al.  The molecular role of the common gamma c subunit in signal transduction reveals functional asymmetry within multimeric cytokine receptor complexes. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[19]  W. Leonard,et al.  The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. , 1995, Immunity.

[20]  W. Paul,et al.  An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth , 1994, Cell.

[21]  D. Williams,et al.  A thymic stromal cell line supports in vitro development of surface IgM+ B cells and produces a novel growth factor affecting B and T lineage cells. , 1994, Experimental hematology.

[22]  T. S. P. S.,et al.  GROWTH , 1924, Nature.