Sch 9 Is a Major Target of TORC 1 in Saccharomyces cerevisiae

Jörg Urban, Alexandre Soulard, Alexandre Huber, Soyeon Lippman, Debdyuti Mukhopadhyay, Olivier Deloche, Valeria Wanke, Dorothea Anrather, Gustav Ammerer, Howard Riezman, James R. Broach, Claudio De Virgilio, Michael N. Hall, and Robbie Loewith* Department of Molecular Biology Department of Biochemistry Department of Microbiology and Molecular Medicine, Centre Médical Universitaire University of Geneva, Geneva, CH-1211, Switzerland Department of Biochemistry, Biozentrum, University of Basel, Basel, CH-4056, Switzerland Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA Max F. Perutz Laboratories, Department of Biochemistry, University of Vienna, Dr. Bohrgasse 9, A1030 Vienna, Austria *Correspondence: robbie.loewith@molbio.unige.ch DOI 10.1016/j.molcel.2007.04.020

[1]  D. Guertin,et al.  Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton , 2004, Current Biology.

[2]  Matt Kaeberlein,et al.  Extension of chronological life span in yeast by decreased TOR pathway signaling. , 2006, Genes & development.

[3]  D. V. van Aalten,et al.  PDK1, the master regulator of AGC kinase signal transduction. , 2004, Seminars in cell & developmental biology.

[4]  E. Dubois,et al.  Identification of direct and indirect targets of the Gln3 and Gat1 activators by transcriptional profiling in response to nitrogen availability in the short and long term. , 2006, FEMS yeast research.

[5]  Ted Powers,et al.  Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae. , 2003, Molecular biology of the cell.

[6]  Stephen Garrett,et al.  Multiple roles of Tap42 in mediating rapamycin-induced transcriptional changes in yeast. , 2003, Molecular cell.

[7]  C. Berset,et al.  The TOR (target of rapamycin) signal transduction pathway regulates the stability of translation initiation factor eIF4G in the yeast Saccharomyces cerevisiae. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[8]  R. Loewith,et al.  Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive , 2004, Nature Cell Biology.

[9]  Michael N. Hall,et al.  The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors , 1999, Nature.

[10]  D. Guertin,et al.  Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex , 2005, Science.

[11]  R. Loewith,et al.  Cell growth control: little eukaryotes make big contributions , 2006, Oncogene.

[12]  Natalie L. Catlett,et al.  Vac8p, a Vacuolar Protein with Armadillo Repeats, Functions in both Vacuole Inheritance and Protein Targeting from the Cytoplasm to Vacuole , 1998, The Journal of cell biology.

[13]  J. Warner,et al.  Phosphorylation of the yeast equivalent of ribosomal protein S6 is not essential for growth. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[14]  D. Sabatini,et al.  mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery , 2002, Cell.

[15]  Yoshinori Watanabe,et al.  Schizosaccharomyces pombe AGC family kinase Gad8p forms a conserved signaling module with TOR and PDK1‐like kinases , 2003, The EMBO journal.

[16]  D. Thiele,et al.  The Sch9 protein kinase regulates Hsp90 chaperone complex signal transduction activity in vivo , 1999, The EMBO journal.

[17]  R. Lester,et al.  Signalling functions for sphingolipid long-chain bases in Saccharomyces cerevisiae. , 2005, Biochemical Society transactions.

[18]  J. Thorner,et al.  Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast , 1999, Current Biology.

[19]  J. Heitman,et al.  The TOR Kinases Link Nutrient Sensing to Cell Growth* , 2001, The Journal of Biological Chemistry.

[20]  M. Tyers,et al.  A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size. , 2004, Genes & development.

[21]  D. Barford,et al.  Lining the pockets of kinases and phosphatases. , 2006, Current opinion in structural biology.

[22]  Alex Sobko.  Systems Biology of AGC Kinases in Fungi , 2006, Science's STKE.

[23]  D. Sabatini,et al.  Redox Regulation of the Nutrient-sensitive Raptor-mTOR Pathway and Complex* , 2005, Journal of Biological Chemistry.

[24]  K. Irie,et al.  PDK1 Homologs Activate the Pkc1–Mitogen-Activated Protein Kinase Pathway in Yeast , 1999, Molecular and Cellular Biology.

[25]  Lisa Schneper,et al.  Sense and sensibility: nutritional response and signal integration in yeast. , 2004, Current opinion in microbiology.

[26]  Kenta Hara,et al.  Immunopurified Mammalian Target of Rapamycin Phosphorylates and Activates p70 S6 Kinase α in Vitro * , 1999, The Journal of Biological Chemistry.

[27]  S. Snyder,et al.  RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[28]  Ted Powers,et al.  TOR Complex 1 Includes a Novel Component, Tco89p (YPL180w), and Cooperates with Ssd1p to Maintain Cellular Integrity in Saccharomyces cerevisiae* , 2004, Journal of Biological Chemistry.

[29]  Chao Cheng,et al.  Sir2 Blocks Extreme Life-Span Extension , 2005, Cell.

[30]  I. Stansfield,et al.  An MBoC Favorite: TOR controls translation initiation and early G1 progression in yeast , 2012, Molecular biology of the cell.

[31]  R. Loewith,et al.  Tor2 Directly Phosphorylates the AGC Kinase Ypk2 To Regulate Actin Polarization , 2005, Molecular and Cellular Biology.

[32]  J. Crespo,et al.  The GATA Transcription Factors GLN3 and GAT1 Link TOR to Salt Stress in Saccharomyces cerevisiae * , 2001, The Journal of Biological Chemistry.

[33]  S. Schreiber,et al.  PIK-Related Kinases: DNA Repair, Recombination, and Cell Cycle Checkpoints , 1995, Science.

[34]  R. Burgess,et al.  Mapping protein-protein interaction domains using ordered fragment ladder far-western analysis of hexahistidine-tagged fusion proteins. , 2000, Methods in enzymology.

[35]  D. Sabatini,et al.  Structure of S6 Kinase 1 Determines whether Raptor-mTOR or Rictor-mTOR Phosphorylates Its Hydrophobic Motif Site*♦ , 2005, Journal of Biological Chemistry.

[36]  Matt Kaeberlein,et al.  Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients , 2005, Science.

[37]  G. Thomas,et al.  9 S6K Integrates Nutrient and Mitogen Signals to Control Cell Growth , 2004 .

[38]  Ivo Pedruzzi,et al.  TOR and PKA signaling pathways converge on the protein kinase Rim15 to control entry into G0. , 2003, Molecular cell.

[39]  P. Cohen,et al.  Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B , 1995, Nature.

[40]  A. Hinnebusch,et al.  Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2. , 2003, Genes & development.

[41]  E. Garí,et al.  TOR Regulates the Subcellular Localization of Ime1, a Transcriptional Activator of Meiotic Development in Budding Yeast , 2003, Molecular and Cellular Biology.

[42]  J. Crespo,et al.  Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. , 2002, Molecular cell.