Infection with mosquito-borne alphavirus induces selective loss of dopaminergic neurons, neuroinflammation and widespread protein aggregation

[1]  L. Sechi,et al.  Inflammation, Infectious Triggers, and Parkinson's Disease , 2019, Front. Neurol..

[2]  Rudolph E. Tanzi,et al.  Alzheimer’s Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection , 2018, Neuron.

[3]  Pranav U. Damale,et al.  The Nurr1 Ligand,1,1-bis(3′-Indolyl)-1-(p-Chlorophenyl)Methane, Modulates Glial Reactivity and Is Neuroprotective in MPTP-Induced Parkinsonism , 2018, The Journal of Pharmacology and Experimental Therapeutics.

[4]  Marco Prinz,et al.  Microglial control of astrocytes in response to microbial metabolites , 2018, Nature.

[5]  Joseph R. Patterson,et al.  Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration , 2018, Journal of Neuroinflammation.

[6]  L. Facci,et al.  An Inflammation-Centric View of Neurological Disease: Beyond the Neuron , 2018, Front. Cell. Neurosci..

[7]  J. Trojanowski,et al.  Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term , 2017, Acta Neuropathologica.

[8]  M. Tansey,et al.  Microglial phenotypes in Parkinson’s disease and animal models of the disease , 2017, Progress in Neurobiology.

[9]  G. Wong,et al.  A Role for Neuronal Alpha-Synuclein in Gastrointestinal Immunity , 2017, Journal of Innate Immunity.

[10]  R. Abraham,et al.  The Pten-Parkin Axis: At the Nexus of Cancer and Neurodegeneration. , 2017, Molecular cell.

[11]  K. Dineley,et al.  Mouse Model of Neurological Complications Resulting from Encephalitic Alphavirus Infection , 2017, Front. Microbiol..

[12]  D. Antipova,et al.  Expression of DJ-1 in Neurodegenerative Disorders. , 2017, Advances in experimental medicine and biology.

[13]  A. Powers,et al.  Venezuelan and western equine encephalitis virus E1 liposome antigen nucleic acid complexes protect mice from lethal challenge with multiple alphaviruses. , 2016, Virology.

[14]  John Q Trojanowski,et al.  Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson’s disease , 2016, The Journal of experimental medicine.

[15]  Robert E. Schmidt,et al.  A complement–microglial axis drives synapse loss during virus-induced memory impairment , 2016, Nature.

[16]  K. Schäfers,et al.  6‐hydroxydopamine‐induced Parkinson's disease‐like degeneration generates acute microgliosis and astrogliosis in the nigrostriatal system but no bioluminescence imaging‐detectable alteration in adult neurogenesis , 2016, The European journal of neuroscience.

[17]  K. Olson,et al.  Entry Sites of Venezuelan and Western Equine Encephalitis Viruses in the Mouse Central Nervous System following Peripheral Infection , 2016, Journal of Virology.

[18]  S. Baldelli,et al.  Redox Imbalance and Viral Infections in Neurodegenerative Diseases , 2016, Oxidative medicine and cellular longevity.

[19]  Hui Zheng,et al.  Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease , 2016, The Journal of Neuroscience.

[20]  G. Wenning,et al.  Glia and alpha-synuclein in neurodegeneration: A complex interaction , 2016, Neurobiology of Disease.

[21]  A. Massey,et al.  Alpha-Synuclein Expression Restricts RNA Viral Infections in the Brain , 2015, Journal of Virology.

[22]  Alan S. Brown,et al.  Neurotropic virus infections as the cause of immediate and delayed neuropathology , 2015, Acta Neuropathologica.

[23]  Stanislav S Zakharenko,et al.  SCYL2 Protects CA3 Pyramidal Neurons from Excitotoxicity during Functional Maturation of the Mouse Hippocampus , 2015, The Journal of Neuroscience.

[24]  B. Geiss,et al.  Oxidative stress influences positive strand RNA virus genome synthesis and capping , 2014, Virology.

[25]  P. Greengard,et al.  Molecular determinants of selective dopaminergic vulnerability in Parkinson’s disease: an update , 2014, Front. Neuroanat..

[26]  B. Žagrović Life is translation , 2014, RNA biology.

[27]  A. Powers,et al.  Liposome-Antigen-Nucleic Acid Complexes Protect Mice from Lethal Challenge with Western and Eastern Equine Encephalitis Viruses , 2013, Journal of Virology.

[28]  K. Tyler,et al.  Death Receptor-Mediated Apoptotic Signaling Is Activated in the Brain following Infection with West Nile Virus in the Absence of a Peripheral Immune Response , 2013, Journal of Virology.

[29]  C. Barcia Glial-Mediated Inflammation Underlying Parkinsonism , 2013, Scientifica.

[30]  Simon C Watkins,et al.  Automated imaging system for fast quantitation of neurons, cell morphology and neurite morphometry in vivo and in vitro , 2013, Neurobiology of Disease.

[31]  Aaron S. Andalman,et al.  Structural and molecular interrogation of intact biological systems , 2013, Nature.

[32]  D. Colagiovanni,et al.  Neuroprotective Efficacy and Pharmacokinetic Behavior of Novel Anti-Inflammatory Para-Phenyl Substituted Diindolylmethanes in a Mouse Model of Parkinson’s Disease , 2013, The Journal of Pharmacology and Experimental Therapeutics.

[33]  M. Tansey,et al.  Neuroimmunological processes in Parkinson's disease and their relation to α-synuclein: microglia as the referee between neuronal processes and peripheral immunity , 2013, ASN neuro.

[34]  Ann M. Powers,et al.  Bioluminescent Imaging and Histopathologic Characterization of WEEV Neuroinvasion in Outbred CD-1 Mice , 2013, PloS one.

[35]  A. Palamara,et al.  Infectious Agents and Neurodegeneration , 2012, Molecular Neurobiology.

[36]  H. Ren,et al.  Immune-related GTPase M (IRGM1) regulates neuronal autophagy in a mouse model of stroke , 2012, Autophagy.

[37]  F. Althaus,et al.  Cell Death and Autophagy under Oxidative Stress: Roles of Poly(ADP-Ribose) Polymerases and Ca2+ , 2012, Molecular and Cellular Biology.

[38]  J. Darnell,et al.  Cytoplasmic RNA-binding proteins and the control of complex brain function. , 2012, Cold Spring Harbor perspectives in biology.

[39]  A. T. da Poian,et al.  Mitochondrial Bioenergetic Alterations in Mouse Neuroblastoma Cells Infected with Sindbis Virus: Implications to Viral Replication and Neuronal Death , 2012, PloS one.

[40]  F. Althaus,et al.  Cell Death and Autophagy under Oxidative Stress: Roles of Poly(ADP-Ribose) Polymerases and Ca 2 (cid:1) , 2012 .

[41]  F. Wu,et al.  Quantitative assessment of gait and neurochemical correlation in a classical murine model of Parkinson’s disease , 2012, BMC Neuroscience.

[42]  M. Philbert,et al.  1,3-Dinitrobenzene-induced metabolic impairment through selective inactivation of the pyruvate dehydrogenase complex. , 2011, Toxicological sciences : an official journal of the Society of Toxicology.

[43]  Huanchun Chen,et al.  Japanese encephalitis virus infection induces changes of mRNA profile of mouse spleen and brain , 2011, Virology Journal.

[44]  M. Okun,et al.  Parkinsonism and neurological manifestations of influenza throughout the 20th and 21st centuries. , 2010, Parkinsonism & related disorders.

[45]  Tiago Gil Oliveira,et al.  Phospholipase D in brain function and Alzheimer's disease. , 2010, Biochimica et biophysica acta.

[46]  David Boltz,et al.  Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration , 2009, Proceedings of the National Academy of Sciences.

[47]  A. Brault,et al.  Virulence variation among isolates of western equine encephalitis virus in an outbred mouse model. , 2009, The Journal of general virology.

[48]  Jenny J. Yang,et al.  Viral calciomics: Interplays between Ca2+ and virus , 2009, Cell Calcium.

[49]  D. Welsh,et al.  Expression of the circadian clock gene Period2 in the hippocampus: possible implications for synaptic plasticity and learned behaviour , 2009, ASN neuro.

[50]  E. Hirsch,et al.  Neuroinflammation in Parkinson's disease: a target for neuroprotection? , 2009, The Lancet Neurology.

[51]  M. Onofrj,et al.  Peripheral cytokines profile in Parkinson’s disease , 2009, Brain, Behavior, and Immunity.

[52]  H. Neumann,et al.  Debris clearance by microglia: an essential link between degeneration and regeneration , 2008, Brain : a journal of neurology.

[53]  R. Webster,et al.  Viral parkinsonism. , 2009, Biochimica et biophysica acta.

[54]  Erik Stolterman,et al.  Complex interaction , 2010, TCHI.

[55]  K. Jellinger,et al.  The dorsal motor nucleus of the vagus is not an obligatory trigger site of Parkinson's disease , 2008, Neuropathology and applied neurobiology.

[56]  M. Graeber,et al.  Controversies over the staging of α-synuclein pathology in Parkinson’s disease , 2008, Acta Neuropathologica.

[57]  Julie M. Robillard,et al.  Hippocampal long-term depression mediates acute stress-induced spatial memory retrieval impairment , 2007, Proceedings of the National Academy of Sciences.

[58]  J. Richter,et al.  CPEB: a life in translation. , 2007, Trends in biochemical sciences.

[59]  Y. Mizuno,et al.  p53 protein, interferon-γ, and NF-κB levels are elevated in the parkinsonian brain , 2007, Neuroscience Letters.

[60]  Y. Mizuno,et al.  p53 protein, interferon-gamma, and NF-kappaB levels are elevated in the parkinsonian brain. , 2007, Neuroscience letters.

[61]  B. Sperlágh,et al.  Purinergic modulation of microglial cell activation , 2006, Purinergic Signalling.

[62]  R. Barbour,et al.  Phosphorylation of Ser-129 Is the Dominant Pathological Modification of α-Synuclein in Familial and Sporadic Lewy Body Disease* , 2006, Journal of Biological Chemistry.

[63]  G. Defazio,et al.  Reversible Parkinsonian syndrome associated with anti-neuronal antibodies in acute EBV encephalitis: a case report. , 2006, Parkinsonism & related disorders.

[64]  I. Milanov,et al.  Acute reversible parkinsonism in Epstein–Bbarr virus–related encephalitis lethargica‐like illness , 2006, Movement disorders : official journal of the Movement Disorder Society.

[65]  C. Colwell,et al.  Melatonin inhibits hippocampal long‐term potentiation , 2005, The European journal of neuroscience.

[66]  J. Richter,et al.  Activity-dependent polyadenylation in neurons. , 2005, RNA.

[67]  F. Lewy Die Entstehung der Einschlußkörper und ihre Bedeutung für die systematische Einordnung der sogenannten Viruskrankheiten , 1932, Deutsche Zeitschrift für Nervenheilkunde.

[68]  Mark P. Mattson,et al.  Infectious agents and age-related neurodegenerative disorders , 2003, Ageing Research Reviews.

[69]  Diane E. Griffin,et al.  Luciferase Imaging of a Neurotropic Viral Infection in Intact Animals , 2003, Journal of Virology.

[70]  H. Braak,et al.  Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen , 2003, Journal of Neural Transmission.

[71]  Yi-shuian Huang,et al.  Facilitation of dendritic mRNA transport by CPEB. , 2003, Genes & development.

[72]  H. Braak,et al.  Staging of brain pathology related to sporadic Parkinson’s disease , 2003, Neurobiology of Aging.

[73]  Bruce Cree,et al.  A fatal case of coxsackievirus B4 meningoencephalitis. , 2003, Archives of neurology.

[74]  Lue Kh,et al.  Parkinson-like syndrome as the major presenting symptom of Epstein–Barr virus encephalitis , 2002 .

[75]  S. Novis,et al.  Movement disorders in 28 HIV-infected patients. , 2002, Arquivos de neuro-psiquiatria.

[76]  U. Muthane,et al.  Persistent movement disorders following Japanese encephalitis , 2001, Neurology.

[77]  J. Taubenberger,et al.  Experimenting on the Past: The Enigma of von Economo's Encephalitis Lethargica , 2001, Journal of neuropathology and experimental neurology.

[78]  B. Hersh,et al.  Parkinsonism as the presenting manifestation of HIV infection: Improvement on HAART , 2001, Neurology.

[79]  G. Arendt,et al.  HIV dementia: the role of the basal ganglia and dopaminergic systems , 2000, Journal of psychopharmacology.

[80]  R. Dobbs,et al.  Association of circulating TNF‐α and IL‐6 with ageing and parkinsonism , 1999 .

[81]  R. Dobbs,et al.  Association of circulating TNF-alpha and IL-6 with ageing and parkinsonism. , 1999, Acta neurologica Scandinavica.

[82]  E. Quinlan,et al.  CPEB-Mediated Cytoplasmic Polyadenylation and the Regulation of Experience-Dependent Translation of α-CaMKII mRNA at Synapses , 1998, Neuron.

[83]  R. Dourmashkin What caused the 1918–30 Epidemic of Encephalitis Lethargica? , 1997, Journal of the Royal Society of Medicine.

[84]  F. Iannotti,et al.  Differential Vulnerability of the CA1 and CA3 Subfields of the Hippocampus to Superoxide and Hydroxyl Radicals In Vitro , 1997, Journal of neurochemistry.

[85]  W. Hall,et al.  A rat model of Parkinson's disease induced by Japanese encephalitis virus. , 1997, Journal of neurovirology.

[86]  D. C. Henckel,et al.  Case report. , 1995, Journal.

[87]  D. Griffin,et al.  Persistence of viral RNA in mouse brains after recovery from acute alphavirus encephalitis , 1992, Journal of virology.

[88]  J. Casals,et al.  Astrogliosis in von Economo's and postencephalitic Parkinson's diseases support probable viral etiology , 1991, Journal of Neurological Sciences.

[89]  K. Johnson An Update. , 1984, Journal of food protection.

[90]  C. Garrett,et al.  Western equine encephalitis with rapid onset of parkinsonism , 1977, Neurology.

[91]  C. Liu,et al.  A comparative study of the pathogenesis of western equine and eastern equine encephalomyelitis viral infections in mice by intracerebral and subcutaneous inoculations. , 1970, The Journal of infectious diseases.