Acute generalized exanthematous pustulosis due to pseudoephedrine with positive patch test.

Sir, Acute generalized exanthematous pustulosis (AGEP) is a cutaneous reaction characterized by an acute nonfollicular pustular eruption overlying a scarlatiniform background, usually associated with high fever and neutrophilia. This rare disease is generally drug-induced, particularly by antibacterial drugs. Only two other cases provoked by pseudoephedrine ingestion have been reported. Patch testing has been advocated recently as a potentially useful test in patients with AGEP. We report here a case of pseudoephedrine-induced AGEP where subsequent patch testing results were positive.

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