Non-genetic Cell-to-cell Variability and the Consequences for Pharmacology This Review Comes from a Themed Issue on Omics Edited the Distribution of Protein Abundance and Resulting Variability in Phenotype Measuring Cell-to-cell Variation
暂无分享,去创建一个
Sabrina L Spencer | Mario Niepel | Peter K Sorger | P. Sorger | S. Spencer | M. Niepel | G. MacBeath | Alan Saghatelian
[1] O. Ornatsky,et al. Mass cytometry: technique for real time single cell multitarget immunoassay based on inductively coupled plasma time-of-flight mass spectrometry. , 2009, Analytical chemistry.
[2] J. Tavaré,et al. Rapid caspase‐3 activation during apoptosis revealed using fluorescence‐resonance energy transfer , 2000, EMBO reports.
[3] L. Pillus,et al. Modifying chromatin and concepts of cancer. , 1999, Current opinion in genetics & development.
[4] E. O’Shea,et al. Noise in protein expression scales with natural protein abundance , 2006, Nature Genetics.
[5] Stephen S. Taylor,et al. Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs. , 2008, Cancer cell.
[6] K. Verstrepen,et al. Timescales of Genetic and Epigenetic Inheritance , 2007, Cell.
[7] Ertugrul M. Ozbudak,et al. Regulation of noise in the expression of a single gene , 2002, Nature Genetics.
[8] K. Svoboda,et al. A genetically encoded fluorescent sensor of ERK activity , 2008, Proceedings of the National Academy of Sciences.
[9] Hannah H. Chang,et al. Non-genetic heterogeneity — a mutation-independent driving force for the somatic evolution of tumours , 2009, Nature Reviews Genetics.
[10] Hannah H. Chang,et al. Transcriptome-wide noise controls lineage choice in mammalian progenitor cells , 2008, Nature.
[11] C. Lim,et al. Regulated Fluctuations in Nanog Expression Mediate Cell Fate Decisions in Embryonic Stem Cells , 2009, PLoS biology.
[12] S. Canevari,et al. Induction of a multifactorial resistance phenotype by high paclitaxel selective pressure in a human ovarian carcinoma cell line. , 2004, Journal of experimental & clinical cancer research : CR.
[13] K. Blumer,et al. G-protein-coupled receptors function as oligomers in vivo , 2000, Current Biology.
[14] Dan L. Longo,et al. Cancer Chemotherapy and Biotherapy: Principles and Practice , 2001 .
[15] P. Swain,et al. Stochastic Gene Expression in a Single Cell , 2002, Science.
[16] D. Gillespie. Exact Stochastic Simulation of Coupled Chemical Reactions , 1977 .
[17] Lani F. Wu,et al. Multidimensional Drug Profiling By Automated Microscopy , 2004, Science.
[18] Lani F. Wu,et al. Image-based multivariate profiling of drug responses from single cells , 2007, Nature Methods.
[19] R. Milo,et al. Variability and memory of protein levels in human cells , 2006, Nature.
[20] R. Yu,et al. Fus3 generates negative feedback that improves information transmission in yeast pheromone response , 2008, Nature.
[21] R. Milo,et al. Oscillations and variability in the p53 system , 2006, Molecular systems biology.
[22] D. Green,et al. A Single Cell Analysis of Apoptosis: Ordering the Apoptotic Phenotype , 2000, Annals of the New York Academy of Sciences.
[23] Jonathan M Irish,et al. Single Cell Profiling of Potentiated Phospho-Protein Networks in Cancer Cells , 2004, Cell.
[24] D B Kell,et al. Oscillations in NF-kappaB signaling control the dynamics of gene expression. , 2004, Science.
[25] R. Germain,et al. Variability and Robustness in T Cell Activation from Regulated Heterogeneity in Protein Levels , 2008, Science.
[26] James R. Johnson,et al. Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression , 2004, Science.
[27] Konstantinos Michalodimitrakis,et al. Noise in transcription negative feedback loops: simulation and experimental analysis , 2006, Molecular systems biology.
[28] Anne E Carpenter,et al. Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins , 2006, Nature Methods.
[29] P. Swain,et al. Gene Regulation at the Single-Cell Level , 2005, Science.
[30] J. Derisi,et al. Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise , 2006, Nature.
[31] Berenbaum Mc,et al. In vivo determination of the fractional kill of human tumor cells by chemotherapeutic agents. , 1972 .
[32] E. Cox,et al. Real-Time Kinetics of Gene Activity in Individual Bacteria , 2005, Cell.
[33] I. Burney. Cancer Chemotherapy and Biotherapy : Principles and Practice , 2011 .
[34] A. van Oudenaarden,et al. Noise Propagation in Gene Networks , 2005, Science.
[35] Uri Alon,et al. Generation of a fluorescently labeled endogenous protein library in living human cells , 2007, Nature Protocols.
[36] P. Hodgkin,et al. A model of immune regulation as a consequence of randomized lymphocyte division and death times , 2007, Proceedings of the National Academy of Sciences.
[37] Adam C. Martin,et al. Critical conformational changes in the Arp2/3 complex are induced by nucleotide and nucleation promoting factor. , 2004, Molecular cell.
[38] Yangzhong Tang,et al. Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate , 2008, Molecular Cancer Therapeutics.
[39] S. Lindquist,et al. Hsp90 Potentiates the Rapid Evolution of New Traits: Drug Resistance in Diverse Fungi , 2005, Science.
[40] D. Lauffenburger,et al. Quantitative analysis of pathways controlling extrinsic apoptosis in single cells. , 2008, Molecular cell.
[41] Matthew R Clutter,et al. High-content single-cell drug screening with phosphospecific flow cytometry. , 2008, Nature chemical biology.
[42] P. Sorger,et al. Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis , 2009, Nature.
[43] Zang Ai-hua,et al. Stem Cells,Cancer and Cancer Stem Cells , 2005 .
[44] M C Berenbaum,et al. In vivo determination of the fractional kill of human tumor cells by chemotherapeutic agents. , 1972, Cancer chemotherapy reports.
[45] L. Liotta,et al. Automated laser capture microdissection for tissue proteomics. , 2008, Methods in molecular biology.
[46] T. Kouzarides. Histone acetylases and deacetylases in cell proliferation. , 1999, Current opinion in genetics & development.
[47] R. Skeel. Handbook of Cancer Chemotherapy , 1995 .
[48] Atsushi Miyawaki,et al. Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression , 2008, Cell.
[49] D. Lauffenburger,et al. Modeling a Snap-Action, Variable-Delay Switch Controlling Extrinsic Cell Death , 2008, PLoS biology.
[50] D. Tranchina,et al. Stochastic mRNA Synthesis in Mammalian Cells , 2006, PLoS biology.
[51] Zhen-ping Zhu,et al. Co-expression of cytokeratin 8 and breast cancer resistant protein indicates a multifactorial drug-resistant phenotype in human breast cancer cell line. , 2008, Life sciences.
[52] Jonathan V Sweedler,et al. Profiling signaling peptides in single mammalian cells using mass spectrometry. , 2006, Analytical chemistry.
[53] K. Sachs,et al. Causal Protein-Signaling Networks Derived from Multiparameter Single-Cell Data , 2005, Science.
[54] R. Milo,et al. Dynamic Proteomics of Individual Cancer Cells in Response to a Drug , 2008, Science.
[55] Gürol M. Süel,et al. An excitable gene regulatory circuit induces transient cellular differentiation , 2006, Nature.