Hydroxysafflor Yellow A Confers Neuroprotection from Focal Cerebral Ischemia by Modulating the Crosstalk Between JAK2/STAT3 and SOCS3 Signaling Pathways

[1]  C. Borlongan,et al.  Autophagy in hemorrhagic stroke: Mechanisms and clinical implications , 2017, Progress in Neurobiology.

[2]  Chun-yang Li,et al.  Inhibition of the SOCS1-JAK2-STAT3 Signaling Pathway Confers Neuroprotection in Rats with Ischemic Stroke , 2017, Cellular Physiology and Biochemistry.

[3]  Xiufen Zheng,et al.  Salvianolic acids enhance cerebral angiogenesis and neurological recovery by activating JAK2/STAT3 signaling pathway after ischemic stroke in mice , 2017, Journal of neurochemistry.

[4]  Wei Zhang,et al.  Major achievements of evidence-based traditional Chinese medicine in treating major diseases. , 2017, Biochemical pharmacology.

[5]  Andrew L. A. Garton,et al.  Current and future perspectives on the treatment of cerebral ischemia , 2017, Expert opinion on pharmacotherapy.

[6]  Yuka Kanno,et al.  Mechanisms and consequences of Jak–STAT signaling in the immune system , 2017, Nature Immunology.

[7]  F. Lombó,et al.  New Insights toward Colorectal Cancer Chemotherapy Using Natural Bioactive Compounds , 2017, Front. Pharmacol..

[8]  M. Sheng,et al.  Propofol postconditioning attenuates hippocampus ischemia-reperfusion injury via modulating JAK2/STAT3 pathway in rats after autogenous orthotropic liver transplantation , 2017, Brain Research.

[9]  Hansen Chen,et al.  One-Compound-Multi-Target: Combination Prospect of Natural Compounds with Thrombolytic Therapy in Acute Ischemic Stroke , 2016, Current neuropharmacology.

[10]  L. Zhiqiang,et al.  Catalpol stimulates VEGF production via the JAK2/STAT3 pathway to improve angiogenesis in rats' stroke model. , 2016, Journal of ethnopharmacology.

[11]  Yan Cheng,et al.  Hydroxysafflor yellow A increases BDNF and NMDARs in the hippocampus in a vascular dementia rat model , 2016, Brain Research.

[12]  Min-Seon Kim,et al.  Leptin signalling pathways in hypothalamic neurons , 2016, Cellular and Molecular Life Sciences.

[13]  Yanni Lv,et al.  Hydroxysafflor yellow A exerts neuroprotective effects in cerebral ischemia reperfusion-injured mice by suppressing the innate immune TLR4-inducing pathway. , 2015, European journal of pharmacology.

[14]  H. Lei,et al.  Oncostatin M Confers Neuroprotection against Ischemic Stroke , 2015, The Journal of Neuroscience.

[15]  Massimo Gadina,et al.  The JAK-STAT pathway: impact on human disease and therapeutic intervention. , 2015, Annual review of medicine.

[16]  Lauren C. Frey,et al.  Effects of JAK2-STAT3 signaling after cerebral insults , 2014, JAK-STAT.

[17]  N. Zhang,et al.  Diosmin protects against cerebral ischemia/reperfusion injury through activating JAK2/STAT3 signal pathway in mice , 2014, Neuroscience.

[18]  Jie Pan,et al.  Hydroxy-safflor yellow A inhibits neuroinflammation mediated by Aβ1–42 in BV-2 cells , 2014, Neuroscience Letters.

[19]  Yan Cheng,et al.  Capacity of HSYA to inhibit nitrotyrosine formation induced by focal ischemic brain injury. , 2013, Nitric oxide : biology and chemistry.

[20]  Huiqing Liu,et al.  Hydroxysafflor Yellow A Protects Against Cerebral Ischemia–Reperfusion Injury by Anti-apoptotic Effect Through PI3K/Akt/GSK3β Pathway in Rat , 2013, Neurochemical Research.

[21]  G. Du,et al.  SMND-309, a novel derivative of salvianolic acid B, protects rat brains ischemia and reperfusion injury by targeting the JAK2/STAT3 pathway. , 2013, European journal of pharmacology.

[22]  N. Nicola,et al.  Regulation of Janus kinases by SOCS proteins. , 2013, Biochemical Society transactions.

[23]  N. Hövelmeyer,et al.  Mechanisms of chronic JAK-STAT3-SOCS3 signaling in obesity , 2013, JAK-STAT.

[24]  Jun He,et al.  NMR solution structure study of the representative component hydroxysafflor yellow A and other quinochalcone C-glycosides from Carthamus tinctorius. , 2013, Journal of natural products.

[25]  R. Shih,et al.  Tissue plasminogen activator and stroke: review of the literature for the clinician. , 2012, The Journal of emergency medicine.

[26]  Ulrich Dirnagl,et al.  Essential role of interleukin-6 in post-stroke angiogenesis. , 2012, Brain : a journal of neurology.

[27]  F. Di Nicuolo,et al.  Effect of Low Molecular Weight Heparins (LMWHs) on antiphospholipid Antibodies (aPL) – Mediated Inhibition of Endometrial Angiogenesis , 2012, PloS one.

[28]  Chen Chang,et al.  Stroke, angiogenesis and phytochemicals. , 2012, Frontiers in bioscience.

[29]  A. Yoshimura,et al.  Suppressors of cytokine signaling (SOCS) proteins and JAK/STAT pathways: regulation of T-cell inflammation by SOCS1 and SOCS3. , 2011, Arteriosclerosis, thrombosis, and vascular biology.

[30]  Sai Ma,et al.  Hydroxysafflor Yellow A protects spinal cords from ischemia/reperfusion injury in rabbits , 2010, BMC Neuroscience.

[31]  Guansong Wang,et al.  Hypoxic preconditioning suppresses group III secreted phospholipase A2‐induced apoptosis via JAK2‐STAT3 activation in cortical neurons , 2010, Journal of neurochemistry.

[32]  G. Comi,et al.  Animal Models of Ischemic Stroke. Part Two: Modeling Cerebral Ischemia , 2010, The open neurology journal.

[33]  Jun He,et al.  Two new quinochalcones from the florets of Carthamus tinctorius. , 2010, Organic letters.

[34]  Jingwei Tian,et al.  Hydroxysafflor Yellow A Inhibits Rat Brain Mitochondrial Permeability Transition Pores by a Free Radical Scavenging Action , 2008, Pharmacology.

[35]  Xinmiao Liang,et al.  Characterization of C-glycosyl quinochalcones in Carthamus tinctorius L. by ultraperformance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry. , 2008, Rapid communications in mass spectrometry : RCM.

[36]  Hung Li,et al.  Secretoneurin promotes neuroprotection and neuronal plasticity via the Jak2/Stat3 pathway in murine models of stroke. , 2008, The Journal of clinical investigation.

[37]  R. Vemuganti,et al.  JAK2 and STAT3 activation contributes to neuronal damage following transient focal cerebral ischemia , 2006, Journal of neurochemistry.

[38]  Fenghua Fu,et al.  Hydroxysafflor yellow A protects rat brains against ischemia-reperfusion injury by antioxidant action , 2005, Neuroscience Letters.

[39]  Chunmei Li,et al.  The subchronic toxicity of hydroxysafflor yellow A of 90 days repeatedly intraperitoneal injections in rats. , 2004, Toxicology.

[40]  K. Nakao,et al.  Leptin stimulates ischemia-induced retinal neovascularization: possible role of vascular endothelial growth factor expressed in retinal endothelial cells. , 2004, Diabetes.

[41]  Masato Kubo,et al.  Suppressors of cytokine signaling and immunity , 2003, Nature Immunology.

[42]  P. Heinrich,et al.  Principles of interleukin (IL)-6-type cytokine signalling and its regulation. , 2003, The Biochemical journal.

[43]  D. Hilton,et al.  SOCS: physiological suppressors of cytokine signaling. , 2000, Journal of cell science.

[44]  M. Baggiolini.  Guidebook to cytokines and their receptors , 1995 .

[45]  J. Garcìa,et al.  Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Statistical validation. , 1995, Stroke.

[46]  J. Darnell,et al.  Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. , 1994, Science.

[47]  P. Weinstein,et al.  Reversible middle cerebral artery occlusion without craniectomy in rats. , 1989, Stroke.

[48]  J T Hoff,et al.  Ischemic Brain Edema and the Osmotic Gradient between Blood and Brain , 1988, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.