A treatment for severe nodular acne: a randomized investigator‐blinded, controlled, noninferiority trial comparing fixed‐dose adapalene/benzoyl peroxide plus doxycycline vs. oral isotretinoin

Oral isotretinoin (ISO) is the gold standard for severe nodular acne. However, as some patients are unwilling or unable to take, or are intolerant to, ISO, other options are needed.

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