Creatine phosphokinase values during isotretinoin treatment for acne

Background  Muscle‐related complaints and high creatine phosphokinase (CPK) blood levels have been reported in 15–50% of patients with acne treated with isotretinoin. Clinical investigations about CPK levels in isotretinoin therapy were few, and most of them were case reports. The aim of this study was to investigate the incidence, course, and clinical significance of severe hyperphosphokinasemia in isotretinoin therapy for acne.

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