Electrophysiological and psychophysical examination in patients with optic nerve compression

Compression of the optic nerve causes a descending degeneration of optic nerve fibers. Additionally to the clinical symptoms (loss of visual acuity, scotomas), electrophysiological methods can be used to evaluate the function of the optic nerve (VEP) and the retinal ganglion cell layer (pattern ERG, PERG).In order to investigate the prognostic significance of electrophysiological methods for postoperative recovery of visual function, 11 patients (22 eyes) suffering from compression of the optic nerve or chiasm due to pituitary tumors or meningiomas were investigated prior to and after surgical decompression. Visual acuity and perimetry were compared to preoperatively performed transient pattern VEP and transient PERG (N-95 amplitude).Prior to surgery, the patients suffered from impairment of visual acuity and scotomas. After surgical decompression, visual acuity improved in seven eyes, remained unchanged in 11 eyes and deteriorated in four eyes. Visual field defects improved in 13 eyes, one visual field d...

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