Cytotoxic activity of the novel heterocyclic compound G-11 is primarily mediated through intrinsic apoptotic pathway

[1]  Mahmoud A. Al-Qudah,et al.  Novel anticancer compound [trifluoromethyl-substituted pyrazole N-nucleoside] inhibits FLT3 activity to induce differentiation in acute myeloid leukemia cells. , 2016, Cancer letters.

[2]  A. R. Fernandes,et al.  Heterocyclic Anticancer Compounds: Recent Advances and the Paradigm Shift towards the Use of Nanomedicine’s Tool Box , 2015, Molecules.

[3]  M. Taha,et al.  Antiproliferative activity of the isoindigo 5'-Br in HL-60 cells is mediated by apoptosis, dysregulation of mitochondrial functions and arresting cell cycle at G0/G1 phase. , 2015, Cancer letters.

[4]  Imran Ali,et al.  Heterocyclic Scaffolds: Centrality in Anticancer Drug Development. , 2015, Current drug targets.

[5]  Jalal A. Zahra,et al.  The Pyridone-Annelated Isoindigo (5‘-Cl) Induces Apoptosis, Dysregulation of Mitochondria and Formation of ROS in Leukemic HL-60 Cells , 2015, Cellular Physiology and Biochemistry.

[6]  N. Bradbury,et al.  Mcl-1 promotes lung cancer cell migration by directly interacting with VDAC to increase mitochondrial Ca2+ uptake and reactive oxygen species generation , 2014, Cell Death and Disease.

[7]  S. Bhushan,et al.  Synthesis of 5-substituted-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one analogs and their biological evaluation as anticancer agents: mTOR inhibitors. , 2014, European journal of medicinal chemistry.

[8]  A. Gamal-Eldeen,et al.  Induction of intrinsic apoptosis pathway in colon cancer HCT-116 cells by novel 2-substituted-5,6,7,8-tetrahydronaphthalene derivatives. , 2014, European journal of medicinal chemistry.

[9]  Y. Lim,et al.  Benzochalcones bearing pyrazoline moieties show anti-colorectal cancer activities and selective inhibitory effects on aurora kinases. , 2013, Bioorganic & medicinal chemistry.

[10]  Baoxiang Zhao,et al.  Phosphorylation and nuclear translocation of integrin β4 induced by a chemical small molecule contribute to apoptosis in vascular endothelial cells , 2013, Apoptosis.

[11]  Alan R. Fersht,et al.  Small molecule induced reactivation of mutant p53 in cancer cells , 2013, Nucleic acids research.

[12]  J. Kujawski,et al.  Evaluation of apoptotic activity of new condensed pyrazole derivatives. , 2013, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[13]  A. Piscopo,et al.  Apricot Melanoidins Prevent Oxidative Endothelial Cell Death by Counteracting Mitochondrial Oxidation and Membrane Depolarization , 2012, PloS one.

[14]  L. Bedoya,et al.  The Artemisia L. Genus: A Review of Bioactive Essential Oils , 2012, Molecules.

[15]  F. K. Keter,et al.  Perspective: the potential of pyrazole-based compounds in medicine , 2012, BioMetals.

[16]  Jun-Ying Miao,et al.  Synthesis of novel pyrazole carboxamide derivatives and discovery of modulators for apoptosis or autophagy in A549 lung cancer cells. , 2009, Bioorganic & medicinal chemistry letters.

[17]  David Bebbington,et al.  The discovery of the potent aurora inhibitor MK-0457 (VX-680). , 2009, Bioorganic & medicinal chemistry letters.

[18]  Stephen S. Taylor,et al.  Mitotic drivers—inhibitors of the Aurora B Kinase , 2009, Cancer and Metastasis Reviews.

[19]  W. Plunkett,et al.  Nucleoside analogs: molecular mechanisms signaling cell death , 2008, Oncogene.

[20]  T. Yagura,et al.  Heterocyclic organobismuth(III) induces apoptosis of human promyelocytic leukemic cells through activation of caspases and mitochondrial perturbation. , 2008, Biochemical pharmacology.

[21]  H. Koeffler,et al.  AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo. , 2007, Blood.

[22]  Xin Du,et al.  Requirement of reactive oxygen species generation in apoptosis of leukemia cells induced by 2-methoxyestradiol , 2007, Acta Pharmacologica Sinica.

[23]  Taizo Tasaka,et al.  A novel treatment strategy targeting Aurora kinases in acute myelogenous leukemia , 2007, Molecular Cancer Therapeutics.

[24]  Xiao-dong Wang,et al.  Apoptosis-inducing activity of new pyrazole emodin derivatives in human hepatocellular carcinoma HepG2 cells. , 2007, Biological & pharmaceutical bulletin.

[25]  A. Skaltsounis,et al.  Antiproliferative and proapoptotic activities of pyranoxanthenones, pyranothioxanthenones and their pyrazole-fused derivatives in HL-60 cells. , 2006, Anticancer research.

[26]  S. Kuo,et al.  YC-1 suppresses constitutive nuclear factor-κB activation and induces apoptosis in human prostate cancer cells , 2005, Molecular Cancer Therapeutics.

[27]  E. White,et al.  Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy. , 2005, Cancer cell.

[28]  A. Saleh,et al.  Synthesis and antitumor activity of 5-trifluoromethyl-2,4- dihydropyrazol-3-one nucleosides. , 2004, Molecules.

[29]  W. Plunkett,et al.  Mechanisms of apoptosis induction by nucleoside analogs , 2003, Oncogene.

[30]  T. Kuwana,et al.  Bcl-2-family proteins and the role of mitochondria in apoptosis. , 2003, Current opinion in cell biology.

[31]  A. Saleh,et al.  Paraoxon induces apoptosis in EL4 cells via activation of mitochondrial pathways. , 2003, Toxicology and applied pharmacology.

[32]  A. Saleh,et al.  Effect of malathion on apoptosis of murine L929 fibroblasts: a possible mechanism for toxicity in low dose exposure. , 2003, Toxicology.

[33]  S. Cory,et al.  Apoptosomes: engines for caspase activation. , 2002, Current opinion in cell biology.

[34]  W. Kamps,et al.  Vincristine induced apoptosis in acute lymphoblastic leukaemia cells: a mitochondrial controlled pathway regulated by reactive oxygen species? , 2002, International journal of oncology.

[35]  S. Srinivasula,et al.  Cytochrome c and dATP-mediated Oligomerization of Apaf-1 Is a Prerequisite for Procaspase-9 Activation* , 1999, The Journal of Biological Chemistry.

[36]  F. Durrieu,et al.  Transition from Caspase-dependent to Caspase-independent Mechanisms at the Onset of Apoptotic Execution , 1998, The Journal of cell biology.

[37]  J. Inazawa,et al.  Molecular cloning and characterization of human caspase-activated DNase. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[38]  Xiaodong Wang,et al.  Induction of an apoptotic program in cell-free extracts by 2-chloro-2'-deoxyadenosine 5'-triphosphate and cytochrome c. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[39]  S. Nagata,et al.  A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD , 1998, Nature.

[40]  Y. Okuda,et al.  [Vascular endothelial cells]. , 1997, Nihon rinsho. Japanese journal of clinical medicine.

[41]  C. Franceschi,et al.  JC‐1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess ΔΨ changes in intact cells: implications for studies on mitochondrial functionality during apoptosis , 1997, FEBS letters.

[42]  Dean P. Jones,et al.  Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked , 1997, Science.

[43]  G. Kroemer,et al.  Mitochondrial permeability transition is a central coordinating event of apoptosis , 1996, The Journal of experimental medicine.

[44]  Z. Darżynkiewicz,et al.  A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry. , 1994, Analytical biochemistry.

[45]  E. Sorkin,et al.  Cladribine , 2012, Drugs.

[46]  D. Faulds,et al.  Fludarabine. A review of its pharmacological properties and therapeutic potential in malignancy. , 1993, Drugs.

[47]  H. Kantarjian,et al.  Response assessment in chronic lymphocytic leukemia after fludarabine plus prednisone: clinical, pathologic, immunophenotypic, and molecular analysis. , 1992, Blood.

[48]  I. Judson Anthrapyrazoles: true successors to the anthracyclines? , 1991, Anti-cancer drugs.