The RGD integrin binding site in human L1-CAM is important for nuclear signaling.

[1]  P. Altevogt,et al.  Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/γ-secretase activity , 2009, The Biochemical journal.

[2]  P. Altevogt,et al.  Antibodies directed against L1-CAM synergize with Genistein in inhibiting growth and survival pathways in SKOV3ip human ovarian cancer cells. , 2008, Cancer letters.

[3]  P. Altevogt,et al.  The cytoplasmic part of L1-CAM controls growth and gene expression in human tumors that is reversed by therapeutic antibodies , 2007, Oncogene.

[4]  G. Sauter,et al.  L1 is associated with micrometastatic spread and poor outcome in colorectal cancer , 2007, Modern Pathology.

[5]  D. Notterman,et al.  Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis. , 2007, Cancer research.

[6]  P. Altevogt,et al.  Drug-induced expression of the cellular adhesion molecule L1CAM confers anti-apoptotic protection and chemoresistance in pancreatic ductal adenocarcinoma cells , 2007, Oncogene.

[7]  P. Altevogt,et al.  L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cells. , 2007, Gynecologic oncology.

[8]  P. Altevogt,et al.  Copper-67 Radioimmunotherapy and Growth Inhibition by Anti–L1-Cell Adhesion Molecule Monoclonal Antibodies in a Therapy Model of Ovarian Cancer Metastasis , 2007, Clinical Cancer Research.

[9]  I. Roninson,et al.  Cell adhesion molecule L1 disrupts E-cadherin-containing adherens junctions and increases scattering and motility of MCF7 breast carcinoma cells. , 2006, Cancer research.

[10]  P. Altevogt,et al.  L1 on ovarian carcinoma cells is a binding partner for Neuropilin-1 on mesothelial cells. , 2006, Cancer letters.

[11]  P. Altevogt,et al.  The adhesion molecule L1 (CD171) promotes melanoma progression , 2006, International journal of cancer.

[12]  P. Altevogt,et al.  Efficient inhibition of intra-peritoneal tumor growth and dissemination of human ovarian carcinoma cells in nude mice by anti-L1-cell adhesion molecule monoclonal antibody treatment. , 2006, Cancer research.

[13]  M. Buhusi,et al.  Endocytosis of beta1 integrins is an early event in migration promoted by the cell adhesion molecule L1. , 2005, Experimental cell research.

[14]  P. Altevogt,et al.  L1 augments cell migration and tumor growth but not β3 integrin expression in ovarian carcinomas , 2005, International journal of cancer.

[15]  P. Altevogt,et al.  Cleavage of L1 in Exosomes and Apoptotic Membrane Vesicles Released from Ovarian Carcinoma Cells , 2005, Clinical Cancer Research.

[16]  P. Altevogt,et al.  L1, a novel target of β-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers , 2005, The Journal of cell biology.

[17]  Y. Allory,et al.  The L1 cell adhesion molecule is induced in renal cancer cells and correlates with metastasis in clear cell carcinomas. , 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.

[18]  M. McMahon,et al.  Extracellular Signal-regulated Kinase (ERK)-dependent Gene Expression Contributes to L1 Cell Adhesion Molecule-dependent Motility and Invasion* , 2004, Journal of Biological Chemistry.

[19]  P. Altevogt,et al.  L1 expression as a predictor of progression and survival in patients with uterine and ovarian carcinomas , 2003, The Lancet.

[20]  Anil Maliyekkel,et al.  Identification of potential anticancer drug targets through the selection of growth-inhibitory genetic suppressor elements. , 2003, Cancer cell.

[21]  M. Hortsch,et al.  Neuroglian activates Echinoid to antagonize the Drosophila EGF receptor signaling pathway , 2003, Development.

[22]  P. Altevogt,et al.  L1 adhesion molecule (CD 171) in development and progression of human malignant melanoma. , 2003, Cancer letters.

[23]  S. Kenwrick,et al.  Cis and trans interactions of L1 with neuropilin‐1 control axonal responses to semaphorin 3A , 2002, The EMBO journal.

[24]  M. Schachner,et al.  Overexpression of the cell adhesion molecule L1 is associated with metastasis in cutaneous malignant melanoma. , 2002, European journal of cancer.

[25]  B. Midkiff,et al.  The Neural Cell Adhesion Molecule L1 Potentiates Integrin-Dependent Cell Migration to Extracellular Matrix Proteins , 2002, The Journal of Neuroscience.

[26]  W. Paulus,et al.  L1 expressed by glioma cells promotes adhesion but not migration , 2002, Glia.

[27]  P. Altevogt,et al.  Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins , 2001, The Journal of cell biology.

[28]  C. Siu,et al.  PC12 cells utilize the homophilic binding site of L1 for cell−cell adhesion but L1–αvβ3 interaction for neurite outgrowth , 2001 .

[29]  P. Altevogt,et al.  Characterization of the L1-Neurocan-binding Site , 2000, The Journal of Biological Chemistry.

[30]  P. Altevogt,et al.  Role of Src Kinases in the ADAM-mediated Release of L1 Adhesion Molecule from Human Tumor Cells* , 2000, The Journal of Biological Chemistry.

[31]  M. Hortsch Structural and Functional Evolution of the L1 Family: Are Four Adhesion Molecules Better Than One? , 2000, Molecular and Cellular Neuroscience.

[32]  P. Altevogt,et al.  Integrin and Neurocan Binding to L1 Involves Distinct Ig Domains* , 1999, The Journal of Biological Chemistry.

[33]  S. Kenwrick,et al.  Neural cell recognition molecule L1: from cell biology to human hereditary brain malformations , 1998, Current Opinion in Neurobiology.

[34]  D. Cheresh,et al.  A Single Immunoglobulin-like Domain of the Human Neural Cell Adhesion Molecule L1 Supports Adhesion by Multiple Vascular and Platelet Integrins , 1997, The Journal of cell biology.

[35]  J. Becker,et al.  Human neural cell adhesion molecule L1 and rat homologue NILE are ligands for integrin alpha v beta 3 , 1996, The Journal of cell biology.

[36]  P. Altevogt,et al.  The L1 adhesion molecule is a cellular ligand for VLA-5 , 1995, The Journal of cell biology.

[37]  T. Jessell,et al.  TAG-1 can mediate homophilic binding, but neurite outgrowth on TAG-1 requires an L1-like molecule and β1 integrins , 1994, Neuron.

[38]  D. Teplow,et al.  Neural adhesion molecule L1 as a member of the immunoglobulin superfamily with binding domains similar to fibronectin , 1988, Nature.

[39]  P. Bevilacqua L1 , 2002 .

[40]  C. Siu,et al.  PC12 cells utilize the homophilic binding site of L1 for cell-cell adhesion but L1-alphavbeta3 interaction for neurite outgrowth. , 2001, Journal of neurochemistry.