IgG4 and IgE antibodies in atopic dermatitis and urticaria

In comparison with patients having chronic idiopathic urticaria and controls adult atopic dermatitis patients were found to have significantly increased values of total scrum IgG4 and IgE; the mean values seen in the subgroup with moderate/severe dermatitis being higher than those with mild disease (P < 0·5). Total serum IgG4 and IgE levels showed variable or no fluctuation during the follow‐up period, with the exception of the marked reduction post‐treatment in the subgroup receiving systemic corticosteroids which was accompanied by clinical improvement. Total serum IgG4 and IgE levels were low in both control and urticaria groups, IgG4 being lower in the urticaria group (P < 0·05). Specific antibodies of the IgG4 and IgE classes were found to be primarily directed against food and specific inhalant allergens, respectively. Unlike rye and house‐dust mite, specific antibodies to ovalbumin and bovine lactoglobulin were frequently detected in all groups, though at low titres in urticaria and healthy non‐atopic control subjects.

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