As described at previous ASME-PVP Conferences, large efforts have been devoted by the Italian Agency for New Technology, Energy and the Environment (ENEA), with the cooperation of several further members of the Italian Working Group on Seismic Isolation (GLIS), to the development, validation and application of innovative anti-seismic (IAS) techniques since 1988. Considered have been base and floor seismic isolation systems, energy dissipation systems consisting of various types of passive devices (elastic-plastic, viscous, visco-elastic and electro-inductive dampers), hydraulic coupling systems using innovative shock transmitters, systems formed by shape memory alloy devices and more recently, semi-active control systems of vibrations. New activities at ENEA, which are in progress in the framework of both international and national collaborations, concern the development of new IAS systems of the aforesaid kinds to be applied to: • civil structures (bridges, viaducts and buildings of various types) and industrial plants, in both cases to be constructed or seismically retrofitted; • cultural heritage to be restored or reconstructed, or masterpieces to be seismically protected. This paper focuses on the progress of the studies concerning the first kind of structures (SPIDER, SPACE, ALGA-DECS and ISI Projects), while that for cultural heritage has been dealt with in a separate paper presented at this Conference. In addition, some new projects involving ENEA, which were recently proposed to the European Commission and Italian Ministry for the Environment, are mentioned. The ENEA activities being performed for the above-mentioned projects take advantage of the collaboration of the Universities of Bologna and Ancona and “Studio Antonucci” consulting office. The most recent results of the numerical and experimental studies confirm the adequacy and benefits of the proposed systems for the construction or retrofit the various types of considered structures. Finally, it is worthwhile stressing that two further separate papers presented at this Conference deal with the main features and results of the 7th International Seminar on Seismic Isolation, Passive Energy Dissipation and Active Control of Vibrations of Structures (Assisi, Italy, October 2–5, 2001), which was organized by GLIS with the support of ENEA, and the series of films on the IAS techniques which have been produced in the framework of the MUSICA Project.© 2002 ASME