A new safety index based on intrapulse monitoring of ultra-harmonic cavitation during ultrasound-induced blood-brain barrier opening procedures

[1]  Arpit Patel,et al.  Closed-Loop Spatial and Temporal Control of Cavitation Activity With Passive Acoustic Mapping , 2019, IEEE Transactions on Biomedical Engineering.

[2]  J. Valette,et al.  Feedback control of microbubble cavitation for ultrasound-mediated blood–brain barrier disruption in non-human primates under magnetic resonance guidance , 2019, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[3]  James J. Choi,et al.  Rapid Short-pulse Ultrasound Delivers Drugs Uniformly across the Murine Blood-Brain Barrier with Negligible Disruption. , 2019, Radiology.

[4]  Benoit Larrat,et al.  Acoustic Transmission Factor through the Rat Skull as a Function of Body Mass, Frequency and Position. , 2018, Ultrasound in medicine & biology.

[5]  P. Blanc-Benon,et al.  Surface modes with controlled axisymmetry triggered by bubble coalescence in a high-amplitude acoustic field , 2018, Physical Review E.

[6]  Mark S. Bolding,et al.  Characterization of different bubble formulations for blood-brain barrier opening using a focused ultrasound system with acoustic feedback control , 2018, Scientific Reports.

[7]  Miralam Mahdi,et al.  Numerical analyses of nonlinear behavior of microbubble contrast agents in ultrasound field and effective parameters. , 2018, Journal of the Acoustical Society of America.

[8]  Wen-Shiang Chen,et al.  Ultrafast monitoring and control of subharmonic emissions of an unseeded bubble cloud during pulsed sonication. , 2018, Ultrasonics sonochemistry.

[9]  P. Blanc-Benon,et al.  Dynamics of nonspherical microbubble oscillations above instability threshold. , 2017, Physical review. E.

[10]  Chanikarn Power,et al.  Closed-loop control of targeted ultrasound drug delivery across the blood–brain/tumor barriers in a rat glioma model , 2017, Proceedings of the National Academy of Sciences.

[11]  M. Versluis,et al.  Focal areas of increased lipid concentration on the coating of microbubbles during short tone-burst ultrasound insonification , 2017, PloS one.

[12]  K. Hynynen,et al.  Noninvasive and targeted delivery of therapeutics to the brain using focused ultrasound , 2017, Neuropharmacology.

[13]  F. Kiessling,et al.  Ultrasound-mediated drug delivery to the brain: principles, progress and prospects. , 2016, Drug discovery today. Technologies.

[14]  Hao-Li Liu,et al.  Real-time monitoring of focused ultrasound blood-brain barrier opening via subharmonic acoustic emission detection: implementation of confocal dual-frequency piezoelectric transducers , 2016, Physics in medicine and biology.

[15]  Jean-François Aubry,et al.  Magnetic resonance-guided motorized transcranial ultrasound system for blood-brain barrier permeabilization along arbitrary trajectories in rodents , 2015, Journal of therapeutic ultrasound.

[16]  E. Konofagou,et al.  Acoustic cavitation-based monitoring of the reversibility and permeability of ultrasound-induced blood-brain barrier opening , 2015, Physics in medicine and biology.

[17]  James J. Choi,et al.  Non-invasive and real-time passive acoustic mapping of ultrasound-mediated drug delivery , 2014, Physics in medicine and biology.

[18]  Nico De Jong,et al.  Lipid shedding from single oscillating microbubbles. , 2014, Ultrasound in medicine & biology.

[19]  Wayne Kreider,et al.  Passive cavitation detection during pulsed HIFU exposures of ex vivo tissues and in vivo mouse pancreatic tumors. , 2014, Ultrasound in medicine & biology.

[20]  M. Doyley,et al.  The delayed onset of subharmonic and ultraharmonic emissions from a phospholipid-shelled microbubble contrast agent. , 2014, Ultrasound in medicine & biology.

[21]  E. Stride,et al.  Surfactant shedding and gas diffusion during pulsed ultrasound through a microbubble contrast agent suspension. , 2013, The Journal of the Acoustical Society of America.

[22]  Ayache Bouakaz,et al.  Second harmonic and subharmonic for non-linear wideband contrast imaging using a capacitive micromachined ultrasonic transducer array. , 2013, Ultrasound in medicine & biology.

[23]  Margaret S Livingstone,et al.  Combined ultrasound and MR imaging to guide focused ultrasound therapies in the brain , 2013, Physics in medicine and biology.

[24]  P. Tortoli,et al.  Correspondence - Nonlinear oscillations of deflating bubbles , 2012, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control.

[25]  M. Livingstone,et al.  Controlled Ultrasound-Induced Blood-Brain Barrier Disruption Using Passive Acoustic Emissions Monitoring , 2012, PloS one.

[26]  Vassilis Sboros,et al.  The “quasi-stable” lipid shelled microbubble in response to consecutive ultrasound pulses , 2012 .

[27]  Kullervo Hynynen,et al.  Blood-brain barrier: real-time feedback-controlled focused ultrasound disruption by using an acoustic emissions-based controller. , 2012, Radiology.

[28]  C. Coussios,et al.  Quantitative observations of cavitation activity in a viscoelastic medium. , 2011, The Journal of the Acoustical Society of America.

[29]  Lorenzo Galleani,et al.  IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control , 2011, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control.

[30]  Elisa E Konofagou,et al.  Noninvasive and localized neuronal delivery using short ultrasonic pulses and microbubbles , 2011, Proceedings of the National Academy of Sciences.

[31]  James J. Choi,et al.  Noninvasive and Localized Blood—Brain Barrier Disruption using Focused Ultrasound can be Achieved at Short Pulse Lengths and Low Pulse Repetition Frequencies , 2011, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[32]  Nico de Jong,et al.  Subharmonic behavior of phospholipid-coated ultrasound contrast agent microbubbles. , 2010, The Journal of the Acoustical Society of America.

[33]  Yao-Sheng Tung,et al.  In vivo transcranial cavitation threshold detection during ultrasound-induced blood–brain barrier opening in mice , 2010, Physics in medicine and biology.

[34]  Miklós Gyöngy,et al.  Passive cavitation mapping for localization and tracking of bubble dynamics. , 2010, The Journal of the Acoustical Society of America.

[35]  Mark Borden,et al.  Microbubble Compositions, Properties and Biomedical Applications. , 2009, Bubble science engineering and technology.

[36]  K. Hynynen,et al.  Effects of acoustic parameters and ultrasound contrast agent dose on focused-ultrasound induced blood-brain barrier disruption. , 2008, Ultrasound in medicine & biology.

[37]  K. Hynynen,et al.  Targeted disruption of the blood–brain barrier with focused ultrasound: association with cavitation activity , 2006, Physics in medicine and biology.

[38]  P. Dayton,et al.  Influence of lipid shell physicochemical properties on ultrasound-induced microbubble destruction , 2005, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[39]  Detlef Lohse,et al.  A model for large amplitude oscillations of coated bubbles accounting for buckling and rupture , 2005 .

[40]  Nico de Jong,et al.  Ultrasound-induced microbubble coalescence. , 2004, Ultrasound in medicine & biology.

[41]  K. Hynynen,et al.  The threshold for brain damage in rabbits induced by bursts of ultrasound in the presence of an ultrasound contrast agent (Optison). , 2003, Ultrasound in medicine & biology.

[42]  Nico de Jong,et al.  Basic Acoustic Properties of Microbubbles , 2002, Echocardiography.

[43]  K. Hynynen,et al.  Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits. , 2001, Radiology.

[44]  K. Hynynen,et al.  Opening the Blood-Brain Barrier with MR Imaging-guided Focused Ultrasound: Preclinical Testing on a Trans-Human Skull Porcine Model. , 2017, Radiology.

[45]  Nader Saffari,et al.  Multi-resolution analysis of passive cavitation detector signals , 2015 .

[46]  W. Pardridge The blood-brain barrier: Bottleneck in brain drug development , 2005, NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics.

[47]  P. Tortoli,et al.  Microbubble characterization through acoustically induced deflation , 2010, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.