论文信息 - HotSpot3D web server: an integrated resource for mutation analysis in protein 3D structures

HotSpot3D web server: an integrated resource for mutation analysis in protein 3D structures

MOTIVATION HotSpot3D is a widely used software for identifying mutation hotspots on the three-dimensional (3D) structures of proteins. To further assist users, we developed a new HotSpot3D web server to make this software more versatile, convenient, and interactive. RESULTS The HotSpot3D web server performs data pre-processing, clustering, visualization, and log-viewing on one stop. Users can interactively explore each cluster and easily re-visualize the mutational clusters within browsers. We also provide a database that allows users to search and visualize proximal mutations from 33 cancers in The Cancer Genome Atlas. AVAILABILITY AND IMPLEMENTATION http://niulab.scgrid.cn/HotSpot3D/. SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.

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