Functional Analysis of PIK 3 CA Gene Mutations in Human Colorectal Cancer
暂无分享,去创建一个
T. Kawabe | M. Omata | T. Obata | A. Jazag | B. Guleng | T. Ikenoue | Y. Hikiba | F. Kanai | Yasuo Tanaka | J. Imamura | M. Ohta | K. Tateishi | M. Matsumura | Y. Asaoka | Yohko Hikiba | Yoshinari Asaoka
[1] P. Vogt,et al. Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[2] Wayne A. Phillips,et al. Mutation of the PIK3CA Gene in Ovarian and Breast Cancer , 2004, Cancer Research.
[3] T. Kawabe,et al. Different Effects of Point Mutations within the B-Raf Glycine-Rich Loop in Colorectal Tumors on Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase/Extracellular Signal-Regulated Kinase and Nuclear Factor κB Pathway and Cellular Transformation , 2004, Cancer Research.
[4] J. Ptak,et al. High Frequency of Mutations of the PIK3CA Gene in Human Cancers , 2004, Science.
[5] Zhenbao Yu,et al. Involvement of the PI 3-kinase signaling pathway in progression of colon adenocarcinoma. , 2003, Carcinogenesis.
[6] T. Kawabe,et al. Functional analysis of mutations within the kinase activation segment of B-Raf in human colorectal tumors. , 2003, Cancer research.
[7] L. Cantley,et al. Targeting the PI3K-Akt pathway in human cancer: rationale and promise. , 2003, Cancer cell.
[8] Y. Gotoh,et al. Differing Roles of Akt and Serum- and Glucocorticoid-regulated Kinase in Glucose Metabolism, DNA Synthesis, and Oncogenic Activity* , 2003, Journal of Biological Chemistry.
[9] Marketa Zvelebil,et al. Phosphoinositide 3-kinase signalling--which way to target? , 2003, Trends in pharmacological sciences.
[10] P. Driscoll,et al. Structural insight into substrate specificity and regulatory mechanisms of phosphoinositide 3-kinases. , 2002, Trends in biochemical sciences.
[11] C. Sawyers,et al. The phosphatidylinositol 3-Kinase–AKT pathway in human cancer , 2002, Nature Reviews Cancer.
[12] Lewis C Cantley,et al. The phosphoinositide 3-kinase pathway. , 2002, Science.
[13] Arnold J Levine,et al. p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas. , 2002, Genes & development.
[14] I. Campbell,et al. The phosphatidylinositol 3'-kinase p85alpha gene is an oncogene in human ovarian and colon tumors. , 2001, Cancer research.
[15] C. Der,et al. Oncogenic Ras Blocks Anoikis by Activation of a Novel Effector Pathway Independent of Phosphatidylinositol 3-Kinase , 2001, Molecular and Cellular Biology.
[16] P. Vogt,et al. A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt. , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[17] Christian Ried,et al. Structural insights into phosphoinositide 3-kinase catalysis and signalling , 1999, Nature.
[18] Joe W. Gray,et al. PIK3CA is implicated as an oncogene in ovarian cancer , 1999, Nature Genetics.
[19] P. Vogt,et al. The akt kinase: molecular determinants of oncogenicity. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[20] A. Klippel,et al. Activation of Phosphatidylinositol 3-Kinase Is Sufficient for Cell Cycle Entry and Promotes Cellular Changes Characteristic of Oncogenic Transformation , 1998, Molecular and Cellular Biology.
[21] J. Backer,et al. Regulation of the p85/p110 Phosphatidylinositol 3′-Kinase: Stabilization and Inhibition of the p110α Catalytic Subunit by the p85 Regulatory Subunit , 1998, Molecular and Cellular Biology.
[22] L. Cantley,et al. Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase. , 1997, Science.
[23] J. Cheng,et al. Transforming activity and mitosis-related expression of the AKT2 oncogene: evidence suggesting a link between cell cycle regulation and oncogenesis , 1997, Oncogene.
[24] P. Warne,et al. Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras , 1997, Cell.
[25] J. Downward,et al. Activation of phosphoinositide 3‐kinase by interaction with Ras and by point mutation. , 1996, The EMBO journal.
[26] Michael J. Fry,et al. Phosphatidylinositol-3-OH kinase direct target of Ras , 1994, Nature.
[27] J. L. Bos,et al. ras oncogenes in human cancer: a review. , 1989, Cancer research.