Opioid Receptor Signal Transduction Mechanisms

[1]  H. Loh,et al.  μ-Opioid Receptor Agonists Differentially Regulate the Expression of miR-190 and NeuroD , 2010, Molecular Pharmacology.

[2]  H. Loh,et al.  GRIN1 Regulates μ-Opioid Receptor Activities by Tethering the Receptor and G Protein in the Lipid Raft* , 2009, The Journal of Biological Chemistry.

[3]  H. Loh,et al.  μ-Opioid Receptor Cell Surface Expression Is Regulated by Its Direct Interaction with Ribophorin I , 2009, Molecular Pharmacology.

[4]  L. Terenius.  Characteristics of the "receptor" for narcotic analgesics in synaptic plasma membrane fraction from rat brain. , 2009, Acta pharmacologica et toxicologica.

[5]  L. Devi,et al.  Receptor heterodimerization leads to a switch in signaling: β‐arrestin2‐mediated ERK activation by μ‐δ opioid receptor heterodimers , 2007 .

[6]  M. Rodríguez-Muñoz,et al.  Sumoylated RGS-Rz Proteins Act as Scaffolds for Mu-Opioid Receptors and G-Protein Complexes in Mouse Brain , 2007, Neuropsychopharmacology.

[7]  S. Lanier,et al.  Mechanistic pathways and biological roles for receptor-independent activators of G-protein signaling. , 2007, Pharmacology & therapeutics.

[8]  M. Waldhoer,et al.  Ligand‐induced down‐regulation of the cannabinoid 1 receptor is mediated by the G‐protein‐coupled receptor‐associated sorting protein GASP1 , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[9]  K. Martemyanov,et al.  The Membrane Anchor R7BP Controls the Proteolytic Stability of the Striatal Specific RGS Protein, RGS9-2*♦ , 2007, Journal of Biological Chemistry.

[10]  W. Xu,et al.  Cholesterol reduction by methyl-beta-cyclodextrin attenuates the delta opioid receptor-mediated signaling in neuronal cells but enhances it in non-neuronal cells. , 2007, Biochemical pharmacology.

[11]  R. A. Moyer,et al.  An Opioid Agonist that Does Not Induce μ-Opioid Receptor—Arrestin Interactions or Receptor Internalization , 2007, Molecular Pharmacology.

[12]  Arthur Christopoulos,et al.  Functional Selectivity and Classical Concepts of Quantitative Pharmacology , 2007, Journal of Pharmacology and Experimental Therapeutics.

[13]  J. Traynor,et al.  Mediation of adenylyl cyclase sensitization by PTX‐insensitive GαoA, Gαi1, Gαi2 or Gαi3 , 2006 .

[14]  C. Chavkin,et al.  Mu Opioid Receptor Activation of ERK1/2 Is GRK3 and Arrestin Dependent in Striatal Neurons* , 2006, Journal of Biological Chemistry.

[15]  R. Wesselschmidt,et al.  μ- and κ-Opioids Induce the Differentiation of Embryonic Stem Cells to Neural Progenitors* , 2006, Journal of Biological Chemistry.

[16]  L. Burns,et al.  Gβγ that interacts with adenylyl cyclase in opioid tolerance originates from a Gs protein , 2006 .

[17]  Michel Bouvier,et al.  Simultaneous Activation of the δ Opioid Receptor (δOR)/Sensory Neuron-Specific Receptor-4 (SNSR-4) Hetero-Oligomer by the Mixed Bivalent Agonist Bovine Adrenal Medulla Peptide 22 Activates SNSR-4 but Inhibits δOR Signaling , 2006, Molecular Pharmacology.

[18]  M. Bruchas,et al.  Kappa Opioid Receptor Activation of p38 MAPK Is GRK3- and Arrestin-dependent in Neurons and Astrocytes* , 2006, Journal of Biological Chemistry.

[19]  K. Martemyanov,et al.  Subcellular Targeting of RGS9-2 Is Controlled by Multiple Molecular Determinants on Its Membrane Anchor, R7BP* , 2006, Journal of Biological Chemistry.

[20]  Z. Vogel,et al.  Adenylyl cyclase type II activity is regulated by two different mechanisms: Implications for acute and chronic opioid exposure , 2006, Neuropharmacology.

[21]  P. Chong,et al.  Localization of the κ Opioid Receptor in Lipid Rafts , 2006, Journal of Pharmacology and Experimental Therapeutics.

[22]  H. Hamm,et al.  Selective interactions between G protein subunits and RGS4 with the C-terminal domains of the mu- and delta-opioid receptors regulate opioid receptor signaling. , 2006, Cellular signalling.

[23]  J. Traynor,et al.  Comparison of the Relative Efficacy and Potency of μ-Opioid Agonists to Activate Gαi/o Proteins Containing a Pertussis Toxin-Insensitive Mutation , 2006, Journal of Pharmacology and Experimental Therapeutics.

[24]  P. Chidiac,et al.  RGS proteins have a signalling complex: interactions between RGS proteins and GPCRs, effectors, and auxiliary proteins. , 2006, Cellular signalling.

[25]  R. Lefkowitz,et al.  Distinct β-Arrestin- and G Protein-dependent Pathways for Parathyroid Hormone Receptor-stimulated ERK1/2 Activation* , 2006, Journal of Biological Chemistry.

[26]  H. Loh,et al.  Adenylyl Cyclase Superactivation Induced by Long-Term Treatment with Opioid Agonist Is Dependent on Receptor Localized within Lipid Rafts and Is Independent of Receptor Internalization , 2006, Molecular Pharmacology.

[27]  Jian-guo Li,et al.  GEC1 Interacts with the κ Opioid Receptor and Enhances Expression of the Receptor* , 2006, Journal of Biological Chemistry.

[28]  H. Loh,et al.  Short- and Long-Term Regulation of Adenylyl Cyclase Activity by δ-Opioid Receptor Are Mediated by Gαi2 in Neuroblastoma N2A Cells , 2006, Molecular Pharmacology.

[29]  Ji Yeoun Yoo,et al.  Adenylyl cyclase type 5 (AC5) is an essential mediator of morphine action. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[30]  B. Sharp,et al.  δ Opioid Receptors Stimulate Akt-Dependent Phosphorylation of c-jun in T Cells , 2006, Journal of Pharmacology and Experimental Therapeutics.

[31]  A. Gintzler,et al.  Phospholipase Cβ1 modulates pain sensitivity, opioid antinociception and opioid tolerance formation , 2006, Brain Research.

[32]  D. Roden,et al.  Cardiac-specific overexpression of AT1 receptor mutant lacking Gαq/Gαi coupling causes hypertrophy and bradycardia in transgenic mice , 2005 .

[33]  M. Zerial,et al.  Phosphorylation of EEA1 by p38 MAP kinase regulates μ opioid receptor endocytosis , 2005, The EMBO journal.

[34]  P. Insel,et al.  G-protein-coupled Receptor Signaling Components Localize in Both Sarcolemmal and Intracellular Caveolin-3-associated Microdomains in Adult Cardiac Myocytes* , 2005, Journal of Biological Chemistry.

[35]  A. López-Fando,et al.  The RGSZ2 Protein Exists in a Complex with μ-Opioid Receptors and Regulates the Desensitizing Capacity of Gz Proteins , 2005, Neuropsychopharmacology.

[36]  M. von Zastrow,et al.  Morphine Promotes Rapid, Arrestin-Dependent Endocytosis of μ-Opioid Receptors in Striatal Neurons , 2005, The Journal of Neuroscience.

[37]  C. Coscia,et al.  μ and κ Opioid Receptors Activate ERK/MAPK via Different Protein Kinase C Isoforms and Secondary Messengers in Astrocytes* , 2005, Journal of Biological Chemistry.

[38]  Jamie Fong,et al.  A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[39]  K. Mcfarland,et al.  Activator of G protein signaling 3 regulates opiate activation of protein kinase A signaling and relapse of heroin-seeking behavior. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[40]  Xiaochun Sun,et al.  Opioid Receptor Homo- and Heterodimerization in Living Cells by Quantitative Bioluminescence Resonance Energy Transfer , 2005, Molecular Pharmacology.

[41]  Maureen P. Boyle,et al.  Palmitoylation regulates plasma membrane–nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family , 2005, The Journal of cell biology.

[42]  M. Rodríguez-Muñoz,et al.  Morphine alters the selective association between mu-opioid receptors and specific RGS proteins in mouse periaqueductal gray matter , 2005, Neuropharmacology.

[43]  Robert J. Lefkowitz,et al.  Transduction of Receptor Signals by ß-Arrestins , 2005, Science.

[44]  A. Burlingame,et al.  Mass spectrometric analysis of agonist effects on posttranslational modifications of the beta-2 adrenoceptor in mammalian cells. , 2005, Biochemistry.

[45]  A. López-Fando,et al.  Activation of μ-Opioid Receptors Transfers Control of Gα Subunits to the Regulator of G-protein Signaling RGS9-2 , 2005, Journal of Biological Chemistry.

[46]  V. Arshavsky,et al.  R7BP, a Novel Neuronal Protein Interacting with RGS Proteins of the R7 Family* , 2005, Journal of Biological Chemistry.

[47]  M. Rodríguez-Muñoz,et al.  RGS-Rz and RGS9-2 proteins control mu-opioid receptor desensitisation in CNS: the role of activated Gαz subunits , 2005, Neuropharmacology.

[48]  B. Ersbøll,et al.  A Library of 7TM Receptor C-terminal Tails , 2004, Journal of Biological Chemistry.

[49]  G. Dubyak,et al.  Erratum: Maitotoxin induces biphasic interleukin-1β secretion and membrane blebbing in murine macrophages (Molecular Pharmacology (2004) 66 (909-920)) , 2004 .

[50]  T. Su,et al.  Role of mPKCI, a novel mu-opioid receptor interactive protein, in receptor desensitization, phosphorylation, and morphine-induced analgesia. , 2004, Molecular pharmacology.

[51]  R. Lefkowitz,et al.  Differential Kinetic and Spatial Patterns of β-Arrestin and G Protein-mediated ERK Activation by the Angiotensin II Receptor* , 2004, Journal of Biological Chemistry.

[52]  M. Caron,et al.  Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery. , 2004, Molecular pharmacology.

[53]  R. Neubig,et al.  Endogenous Regulator of G Protein Signaling Proteins Suppress Gαo-Dependent, μ-Opioid Agonist-Mediated Adenylyl Cyclase Supersensitization , 2004, Journal of Pharmacology and Experimental Therapeutics.

[54]  Angel Y. F. Kam,et al.  Regulation of STAT3 by μ-opioid receptors in human neuroblastoma SH-SY5Y cells , 2004 .

[55]  Zhe Ding,et al.  κ Opioid Receptor Interacts with Na+/H+-exchanger Regulatory Factor-1/Ezrin-Radixin-Moesin-binding Phosphoprotein-50 (NHERF-1/EBP50) to Stimulate Na+/H+ Exchange Independent of Gi/Go Proteins* , 2004, Journal of Biological Chemistry.

[56]  S. Snyder,et al.  Inositol 1,4,5-trisphosphate receptors as signal integrators. , 2004, Annual review of biochemistry.

[57]  A. García-España,et al.  RGSZ1 and GAIP Regulate μ- but Not δ-Opioid Receptors in Mouse CNS: Role in Tachyphylaxis and Acute Tolerance , 2004, Neuropsychopharmacology.

[58]  R. Schulz,et al.  Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinases Block Internalization of δ-Opioid Receptors , 2004, Journal of Pharmacology and Experimental Therapeutics.

[59]  F. Simonin,et al.  Identification of a novel family of G protein‐coupled receptor associated sorting proteins , 2004, Journal of neurochemistry.

[60]  Christopher C Lapish,et al.  Activator of G Protein Signaling 3 A Gatekeeper of Cocaine Sensitization and Drug Seeking , 2004, Neuron.

[61]  Lakshmi A. Devi,et al.  A role for heterodimerization of μ and δ opiate receptors in enhancing morphine analgesia , 2004 .

[62]  R. Fisher,et al.  RGS6 Interacts with DMAP1 and DNMT1 and Inhibits DMAP1 Transcriptional Repressor Activity* , 2004, Journal of Biological Chemistry.

[63]  Y. Wong,et al.  Phosphatidylinositol‐3 kinase is distinctively required for µ‐, but not κ‐opioid receptor‐induced activation of c‐Jun N‐terminal kinase , 2004, Journal of neurochemistry.

[64]  M. Stoffel,et al.  Spinal G-Protein-Gated K+ Channels Formed by GIRK1 and GIRK2 Subunits Modulate Thermal Nociception and Contribute to Morphine Analgesia , 2004, The Journal of Neuroscience.

[65]  M. Narita,et al.  Role of extracellular signal‐regulated kinase in the ventral tegmental area in the suppression of the morphine‐induced rewarding effect in mice with sciatic nerve ligation , 2004, Journal of neurochemistry.

[66]  S. Schulz,et al.  Heterodimerization of Substance P and μ-Opioid Receptors Regulates Receptor Trafficking and Resensitization* , 2003, Journal of Biological Chemistry.

[67]  C. Coscia,et al.  μ Opioid Transactivation and Down-Regulation of the Epidermal Growth Factor Receptor in Astrocytes: Implications for Mitogen-Activated Protein Kinase Signaling , 2003 .

[68]  Wei Xu,et al.  Differential Effects of Agonists on Adenylyl Cyclase Superactivation Mediated by the κ Opioid Receptors: Adenylyl Cyclase Superactivation Is Independent of Agonist-Induced Phosphorylation, Desensitization, Internalization, and Down-Regulation , 2003, Journal of Pharmacology and Experimental Therapeutics.

[69]  M. Groszer,et al.  Phosphoinositide 3-Kinase Cascade Facilitates μ-Opioid Desensitization in Sensory Neurons by Altering G-Protein-Effector Interactions , 2003, The Journal of Neuroscience.

[70]  E. J. Simon,et al.  Interaction Between the μ Opioid Receptor and Filamin A Is Involved in Receptor Regulation and Trafficking , 2003 .

[71]  M. Bootman,et al.  Co-incident signalling between mu-opioid and M3 muscarinic receptors at the level of Ca2+ release from intracellular stores: lack of evidence for Ins(1,4,5)P3 receptor sensitization. , 2003, The Biochemical journal.

[72]  A. López-Fando,et al.  The R7 Subfamily of RGS Proteins Assists Tachyphylaxis and Acute Tolerance at μ-Opioid Receptors , 2003, Neuropsychopharmacology.

[73]  E. Nestler,et al.  Essential role for RGS9 in opiate action , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[74]  H. Loh,et al.  μ-Opioid Receptor Desensitization , 2003, Journal of Biological Chemistry.

[75]  R. Polakiewicz,et al.  Behavioral/systems/cognitive Brain Region-specific Mechanisms for Acute Morphine- Induced Mitogen-activated Protein Kinase Modulation and Distinct Patterns of Activation during Analgesic Tolerance and Locomotor Sensitization Opioid-receptor Activation in Cell Lines Results in Phosphorylation of P42/ , 2022 .

[76]  K. Mackie,et al.  Phosphorylation of a Carboxyl-terminal Serine within the κ-Opioid Receptor Produces Desensitization and Internalization* , 2003, Journal of Biological Chemistry.

[77]  G. Pei,et al.  A novel function of Goα: mediation of extracellular signal‐regulated kinase activation by opioid receptors in neural cells , 2003, Journal of neurochemistry.

[78]  L. Hunyady,et al.  Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2 , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[79]  M. von Zastrow,et al.  Spatial regulation of Galphai protein signaling in clathrin-coated membrane microdomains containing GAIP. , 2003, Molecular pharmacology.

[80]  P. Eriksson,et al.  Opioid-induced proliferation through the MAPK pathway in cultures of adult hippocampal progenitors , 2003, Molecular and Cellular Neuroscience.

[81]  A. López-Fando,et al.  The GBeta5 subunit that associates with the R7 subfamily of RGS proteins regulates mu-opioid effects , 2003, Neuropharmacology.

[82]  V. Hruby,et al.  Converging Protein Kinase Pathways Mediate Adenylyl Cyclase Superactivation upon Chronic δ-Opioid Agonist Treatment , 2003, Journal of Pharmacology and Experimental Therapeutics.

[83]  Krzysztof Palczewski,et al.  Organization of the G Protein-coupled Receptors Rhodopsin and Opsin in Native Membranes* , 2003, Journal of Biological Chemistry.

[84]  H. Schiöth,et al.  The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. , 2003, Molecular pharmacology.

[85]  H. Loh,et al.  Ligand-Selective Activation of μ-Opioid Receptor: Demonstrated with Deletion and Single Amino Acid Mutations of Third Intracellular Loop Domain , 2003, Journal of Pharmacology and Experimental Therapeutics.

[86]  M. Barrot,et al.  Morphine Acutely Regulates Opioid Receptor Trafficking Selectively in Dendrites of Nucleus Accumbens Neurons , 2003, The Journal of Neuroscience.

[87]  R. Neubig,et al.  Endogenous RGS Protein Action Modulates μ-Opioid Signaling through Gαo , 2003, The Journal of Biological Chemistry.

[88]  S. Schulz,et al.  ADP-ribosylation Factor-dependent Phospholipase D2 Activation Is Required for Agonist-induced μ-Opioid Receptor Endocytosis* , 2003, The Journal of Biological Chemistry.

[89]  M. Iglesias,et al.  μ-opioid receptor activation prevents apoptosis following serum withdrawal in differentiated SH-SY5Y cells and cortical neurons via phosphatidylinositol 3-kinase , 2003, Neuropharmacology.

[90]  P. Eriksson,et al.  Mu‐ and delta‐opioid receptor antagonists decrease proliferation and increase neurogenesis in cultures of rat adult hippocampal progenitors , 2003, The European journal of neuroscience.

[91]  M. Rhee,et al.  Up-Regulation of Regulator of G Protein Signaling 4 Expression in a Model of Neuropathic Pain and Insensitivity to Morphine , 2003, Journal of Pharmacology and Experimental Therapeutics.

[92]  G. Aghajanian,et al.  Regulation of RGS proteins by chronic morphine in rat locus coeruleus , 2003, The European journal of neuroscience.

[93]  Y. Sarne,et al.  The mu opioid agonist DAMGO stimulates cAMP production in SK-N-SH cells through a PLC-PKC-Ca++ pathway. , 2003, Brain research. Molecular brain research.

[94]  Angel Y. F. Kam,et al.  Rac and Cdc42‐dependent regulation of c‐Jun N‐terminal kinases by the δ‐opioid receptor , 2003 .

[95]  J. M. Ree,et al.  ERK1/2 activation in rat ventral tegmental area by the μ-opioid agonist fentanyl: an in vitro study , 2003, Neuroscience.

[96]  A. Engel,et al.  Atomic-force microscopy: Rhodopsin dimers in native disc membranes , 2003, Nature.

[97]  M. Stoffel,et al.  Hyperalgesia and blunted morphine analgesia in G protein-gated potassium channel subunit knockout mice , 2002, Neuroreport.

[98]  C. Coscia,et al.  The Fibroblast Growth Factor Receptor Is at the Site of Convergence between μ-Opioid Receptor and Growth Factor Signaling Pathways in Rat C6 Glioma Cells , 2002, Journal of Pharmacology and Experimental Therapeutics.

[99]  H. Ammer,et al.  Identity of adenylyl cyclase isoform determines the G protein mediating chronic opioid‐induced adenylyl cyclase supersensitivity , 2002, Journal of neurochemistry.

[100]  R. Lefkowitz,et al.  Regulation of G protein-coupled receptor signaling by scaffold proteins. , 2002, Circulation research.

[101]  L. Monticelli,et al.  Selective Ligand-induced Stabilization of Active and Desensitized Parathyroid Hormone Type 1 Receptor Conformations* , 2002, The Journal of Biological Chemistry.

[102]  R. Fisher,et al.  RGS6 Interacts with SCG10 and Promotes Neuronal Differentiation , 2002, The Journal of Biological Chemistry.

[103]  M. Sugiyama,et al.  Involvement of Raf-1 in chronic delta-opioid receptor agonist-mediated adenylyl cyclase superactivation. , 2002, European journal of pharmacology.

[104]  M. Nemoto,et al.  Implications of phosphoinositide 3-kinase in the μ- and δ-opioid receptor-mediated supraspinal antinociception in the mouse , 2002, Neuroscience.

[105]  J. Hepler,et al.  Cellular Regulation of RGS Proteins: Modulators and Integrators of G Protein Signaling , 2002, Pharmacological Reviews.

[106]  W. Sadee,et al.  Differential Effects of μ-Opioid Receptor Ligands on Ca2+ Signaling , 2002 .

[107]  Jian-guo Li,et al.  Ezrin-Radixin-Moesin-binding Phosphoprotein-50/Na+/H+ Exchanger Regulatory Factor (EBP50/NHERF) Blocks U50,488H-induced Down-regulation of the Human κ Opioid Receptor by Enhancing Its Recycling Rate* , 2002, The Journal of Biological Chemistry.

[108]  M. von Zastrow,et al.  Modulation of Postendocytic Sorting of G Protein-Coupled Receptors , 2002, Science.

[109]  M. Stoffel,et al.  G-Protein-Gated Potassium Channels Containing Kir3.2 and Kir3.3 Subunits Mediate the Acute Inhibitory Effects of Opioids on Locus Ceruleus Neurons , 2002, The Journal of Neuroscience.

[110]  M. Narita,et al.  Effect of repeated administration of morphine on the activity of extracellular signal regulated kinase in the mouse brain , 2002, Neuroscience Letters.

[111]  B. Kasinath,et al.  Role of P38 Mitogen-Activated Protein Kinase Phosphorylation and Fas-Fas Ligand Interaction in Morphine-Induced Macrophage Apoptosis1 , 2002, The Journal of Immunology.

[112]  Y. Wong,et al.  Co-Expressions of Different Opioid Receptor Types Differentially Modulate Their Signaling via G16 , 2002, Neurosignals.

[113]  L. Limbird,et al.  G protein-coupled receptor interacting proteins: emerging roles in localization and signal transduction. , 2002, Cellular signalling.

[114]  M. Caron,et al.  β-Arrestin/AP-2 Interaction in G Protein-coupled Receptor Internalization , 2002, The Journal of Biological Chemistry.

[115]  R. Ostrom,et al.  New determinants of receptor-effector coupling: trafficking and compartmentation in membrane microdomains. , 2002, Molecular pharmacology.

[116]  E. J. Simon,et al.  Delta Opioid activation of the Mitogen-activated protein kinase cascade does not require transphosphorylation of Receptor Tyrosine Kinases , 2002, BMC pharmacology.

[117]  I. Zagon,et al.  The biology of the opioid growth factor receptor (OGFr) , 2002, Brain Research Reviews.

[118]  L. Bohn,et al.  Mitogenic signaling via endogenous kappa-opioid receptors in C6 glioma cells: evidence for the involvement of protein kinase C and the mitogen-activated protein kinase signaling cascade. , 2001, Journal of neurochemistry.

[119]  Y. Wong,et al.  Role of extracellular signal-regulated kinases in opioid-induced adenylyl cyclase superactivation in human embryonic kidney 293 cells , 2001, Neuroscience Letters.

[120]  R. Lefkowitz,et al.  β-Arrestin-mediated ADP-ribosylation Factor 6 Activation and β2-Adrenergic Receptor Endocytosis* , 2001, The Journal of Biological Chemistry.

[121]  C. Ross,et al.  β1-Adrenergic Receptor Association with the Synaptic Scaffolding Protein Membrane-associated Guanylate Kinase Inverted-2 (MAGI-2) , 2001, The Journal of Biological Chemistry.

[122]  T. Kroslak,et al.  Human Phosphatidylethanolamine-binding Protein Facilitates Heterotrimeric G Protein-dependent Signaling* , 2001, The Journal of Biological Chemistry.

[123]  J. Boulter,et al.  Functional Properties of CaV1.3 (α1D) L-type Ca2+ Channel Splice Variants Expressed by Rat Brain and Neuroendocrine GH3 Cells* , 2001, The Journal of Biological Chemistry.

[124]  T. Kohout,et al.  Regulation of Receptor Fate by Ubiquitination of Activated β2-Adrenergic Receptor and β-Arrestin , 2001, Science.

[125]  H. Morikawa,et al.  Activation of &mgr;-Opioid Receptor Induces Expression of c-fos and junBvia Mitogen-activated Protein Kinase Cascade , 2001, Anesthesiology.

[126]  Robert J. Lefkowitz,et al.  Classical and new roles of β-arrestins in the regulation of G-PROTEIN-COUPLED receptors , 2001, Nature Reviews Neuroscience.

[127]  W. Sadee,et al.  Single Nucleotide Polymorphisms in the Human μ Opioid Receptor Gene Alter Basal G Protein Coupling and Calmodulin Binding* , 2001, The Journal of Biological Chemistry.

[128]  W. Sadee,et al.  μ-Opioid Receptor-mediated ERK Activation Involves Calmodulin-dependent Epidermal Growth Factor Receptor Transactivation* , 2001, The Journal of Biological Chemistry.

[129]  R. Fryer,et al.  Stress-activated protein kinase phosphorylation during cardioprotection in the ischemic myocardium. , 2001, American journal of physiology. Heart and circulatory physiology.

[130]  E. Chatzaki,et al.  The Fas/FasL apoptotic pathway is involved in kappa-opioid-induced apoptosis of human endometrial stromal cells. , 2001, Molecular human reproduction.

[131]  Robert J. Lefkowitz,et al.  Identification of a Motif in the Carboxyl Terminus of β-Arrestin2 Responsible for Activation of JNK3* , 2001, The Journal of Biological Chemistry.

[132]  Y. Wong,et al.  Gα14 links a variety of Gi‐ and Gs‐coupled receptors to the stimulation of phospholipase C , 2001 .

[133]  S. Frank,et al.  The Angiotensin II-dependent Nuclear Translocation of Stat1 Is Mediated by the Jak2 Protein Motif231YRFRR* , 2001, The Journal of Biological Chemistry.

[134]  M. Oppermann,et al.  Chronic morphine induces the concomitant phosphorylation and altered association of multiple signaling proteins: A novel mechanism for modulating cell signaling , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[135]  G. Milligan,et al.  The human δ opioid receptor activates Gi1α more efficiently than Go1α , 2001, Journal of neurochemistry.

[136]  F. Gunn-Moore,et al.  Coincident signalling between the Gi/Go‐coupled δ‐opioid receptor and the Gq‐coupled m3 muscarinic receptor at the level of intracellular free calcium in SH‐SY5Y cells , 2001, Journal of neurochemistry.

[137]  R. Fryer,et al.  ERK and p38 MAP kinase activation are components of opioid-induced delayed cardioprotection , 2001, Basic Research in Cardiology.

[138]  Gang Pei,et al.  Direct binding of β‐arrestins to two distinct intracellular domains of the δ opioid receptor , 2001 .

[139]  Robert J. Lefkowitz,et al.  Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[140]  Wei Hu,et al.  Heterologous Activation of Protein Kinase C Stimulates Phosphorylation of δ-Opioid Receptor at Serine 344, Resulting in β-Arrestin- and Clathrin-mediated Receptor Internalization* , 2001, The Journal of Biological Chemistry.

[141]  P. Sánchez-Blázquez,et al.  RGS9 proteins facilitate acute tolerance to mu‐opioid effects , 2001, The European journal of neuroscience.

[142]  P. Pratt,et al.  Differential activation of extracellular signal regulated kinase isoforms in preconditioning and opioid-induced cardioprotection. , 2001, The Journal of pharmacology and experimental therapeutics.

[143]  L. Devi,et al.  Oligomerization of opioid receptors with beta 2-adrenergic receptors: a role in trafficking and mitogen-activated protein kinase activation. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[144]  D P Siderovski,et al.  Activator of G protein signaling 3 is a guanine dissociation inhibitor for Galpha i subunits. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[145]  Y. J. Lin,et al.  Altered gating of opiate receptor-modulated K+ channels on amygdala neurons of morphine-dependent rats. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[146]  Lan Li,et al.  κ-Opioid receptor potentiates apoptosis via a phospholipase C pathway in the CNE2 human epithelial tumor cell line , 2000 .

[147]  Liaoyuan A. Hu,et al.  β1-Adrenergic Receptor Association with PSD-95 , 2000, The Journal of Biological Chemistry.

[148]  Marc G. Caron,et al.  μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence , 2000, Nature.

[149]  R. Lefkowitz,et al.  Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. , 2000, Science.

[150]  Lakshmi A. Devi,et al.  Heterodimerization of μ and δ Opioid Receptors: A Role in Opiate Synergy , 2000, The Journal of Neuroscience.

[151]  B. Tabakoff,et al.  Overexpression of type 7 adenylyl cyclase in the mouse brain enhances acute and chronic actions of morphine. , 2000, Molecular pharmacology.

[152]  H. Loh,et al.  Deltorphin II-induced Rapid Desensitization of δ-Opioid Receptor Requires Both Phosphorylation and Internalization of the Receptor* , 2000, The Journal of Biological Chemistry.

[153]  J. Grider,et al.  Heterologous desensitization of response mediated by selective PKC-dependent phosphorylation of G(i-1) and G(i-2). , 2000, American journal of physiology. Cell physiology.

[154]  Lakshmi A Devi,et al.  Opioids and Their Complicated Receptor Complexes , 2000, Neuropsychopharmacology.

[155]  N. Bunnett,et al.  The proliferative and antiapoptotic effects of substance P are facilitated by formation of a beta -arrestin-dependent scaffolding complex. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[156]  M. Ohsawa,et al.  Role of the phosphatidylinositol-specific phospholipase C pathway in δ-opioid receptor-mediated antinociception in the mouse spinal cord , 2000, Neuroscience.

[157]  E. J. Simon,et al.  μ and δ-opioid receptor agonists induce mitogen-activated protein kinase (MAPK) activation in the absence of receptor internalization , 2000, Neuropharmacology.

[158]  H. Niki,et al.  Involvement of G-protein-activated inwardly rectifying K+ (GIRK) channels in opioid-induced analgesia , 2000, Neuroscience Research.

[159]  B. O'dowd,et al.  Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties. , 2000, The Journal of biological chemistry.

[160]  T. Kroslak,et al.  Allelic variation S268P of the human mu-opioid receptor affects both desensitization and G protein coupling. , 2000, Molecular pharmacology.

[161]  W. Sadee,et al.  Calmodulin Regulation of Basal and Agonist‐Stimulated G Protein Coupling by the μ‐Opioid Receptor (OP3) in Morphine‐Pretreated Cell , 2000, Journal of neurochemistry.

[162]  M. Caron,et al.  The Interaction of β-Arrestin with the AP-2 Adaptor Is Required for the Clustering of β2-Adrenergic Receptor into Clathrin-coated Pits* , 2000, The Journal of Biological Chemistry.

[163]  Y. Wong,et al.  Evidence for transduction of mu but not kappa opioid modulation of extracellular signal-regulated kinase activity by G(z) and G(12) proteins. , 2000, Cellular signalling.

[164]  H. Loh,et al.  Association of a Lower Molecular Weight Protein to the μ‐Opioid Receptor Demonstrated by 125I‐β‐Endorphin Cross‐Linking Studies , 2000 .

[165]  K. Bernstein,et al.  Jak2 Acts as Both a STAT1 Kinase and as a Molecular Bridge Linking STAT1 to the Angiotensin II AT1 Receptor* , 2000, The Journal of Biological Chemistry.

[166]  R. Lefkowitz,et al.  β-Arrestin1 Interacts with the Catalytic Domain of the Tyrosine Kinase c-SRC , 2000, The Journal of Biological Chemistry.

[167]  Y. Wong,et al.  Regulation of Adenylyl Cyclase, ERK1/2, and CREB by Gz Following Acute and Chronic Activation of the δ‐Opioid Receptor , 2000, Journal of neurochemistry.

[168]  Y. Wong,et al.  Preactivation permits subsequent stimulation of phospholipase C by G(i)-coupled receptors. , 2000, Molecular pharmacology.

[169]  L. Devi,et al.  Opioid receptor endocytosis and activation of MAP kinase pathway. , 2000, Brain research. Molecular brain research.

[170]  E. Chalecka‐Franaszek,et al.  Immunoprecipitation of High‐Affinity, Guanine Nucleotide‐Sensitive, Solubilized μ‐Opioid Receptors from Rat Brain , 2000 .

[171]  E. Chalecka‐Franaszek,et al.  Immunoprecipitation of high-affinity, guanine nucleotide-sensitive, solubilized mu-opioid receptors from rat brain: coimmunoprecipitation of the G proteins G(alpha o), G(alpha i1), and G(alpha i3). , 2000, Journal of neurochemistry.

[172]  L. Bohn,et al.  μ‐Opioid Agonist Inhibition of κ‐Opioid Receptor‐Stimulated Extracellular Signal‐Regulated Kinase Phosphorylation Is Dynamin‐Dependent in C6 Glioma Cells , 2000 .

[173]  V. Höllt,et al.  Involvement of Mitogen‐Activated Protein Kinase in Agonist‐Induced Phosphorylation of the μ‐Opioid Receptor in HEK 293 Cells , 2000, Journal of neurochemistry.

[174]  R. Gainetdinov,et al.  Enhanced morphine analgesia in mice lacking beta-arrestin 2. , 1999, Science.

[175]  H. Loh,et al.  δ-opioid-induced liberation of Gβγ mobilizes Ca2+ stores in NG108- 15 cells , 1999 .

[176]  E. Nestler,et al.  Effects of regulators of G protein-signaling proteins on the functional response of the mu-opioid receptor in a melanophore-based assay. , 1999, The Journal of pharmacology and experimental therapeutics.

[177]  G. Pei,et al.  Endogenous δ‐Opioid and ORL1 Receptors Couple to Phosphorylation and Activation of p38 MAPK in NG108‐15 Cells and This Is Regulated by Protein Kinase A and Protein Kinase C , 1999 .

[178]  A. Bretscher,et al.  A kinase-regulated PDZ-domain interaction controls endocytic sorting of the β2-adrenergic receptor , 1999, Nature.

[179]  R. Gross,et al.  Genetic alteration of phospholipase C β3 expression modulates behavioral and cellular responses to μ opioids , 1999 .

[180]  M. von Zastrow,et al.  Dissociation of Functional Roles of Dynamin in Receptor-mediated Endocytosis and Mitogenic Signal Transduction* , 1999, The Journal of Biological Chemistry.

[181]  E M Ross,et al.  Rapid GTP binding and hydrolysis by G(q) promoted by receptor and GTPase-activating proteins. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[182]  W. Sadee,et al.  Calmodulin Binding to G Protein-coupling Domain of Opioid Receptors* , 1999, The Journal of Biological Chemistry.

[183]  K. Fukuda,et al.  Opioid potentiation of N-type Ca2+ channel currents via pertussis-toxin-sensitive G proteins in NG108-15 cells , 1999, Pflügers Archiv.

[184]  Lakshmi A. Devi,et al.  G-protein-coupled receptor heterodimerization modulates receptor function , 1999, Nature.

[185]  M. T. Frejo,et al.  Stimulation of μ‐ and δ‐opioid receptors enhances phosphoinositide metabolism in mouse spinal cord: evidence for subtypes of δ‐receptors , 1999, The European journal of neuroscience.

[186]  J. Benovic,et al.  U50,488H-induced Internalization of the Human κ Opioid Receptor Involves a β-Arrestin- and Dynamin-dependent Mechanism , 1999, The Journal of Biological Chemistry.

[187]  R. Lefkowitz,et al.  Identification of NSF as a β-Arrestin1-binding Protein , 1999, The Journal of Biological Chemistry.

[188]  H. Loh,et al.  The Absence of a Direct Correlation between the Loss of [d-Ala2,MePhe4,Gly5-ol]Enkephalin Inhibition of Adenylyl Cyclase Activity and Agonist-induced μ-Opioid Receptor Phosphorylation* , 1999, The Journal of Biological Chemistry.

[189]  G L Johnson,et al.  Organization and regulation of mitogen-activated protein kinase signaling pathways. , 1999, Current opinion in cell biology.

[190]  J. Pintar,et al.  μ‐opioid receptor modulation of calcium channel current in periaqueductal grey neurons from C57B16/J mice and mutant mice lacking MOR‐1 , 1999, British journal of pharmacology.

[191]  Gang Pei,et al.  Modulation of Ca2+/Calmodulin-Dependent Protein Kinase II Activity by Acute and Chronic Morphine Administration in Rat Hippocampus: Differential Regulation of α and β Isoforms , 1999 .

[192]  N. Akaike,et al.  μ-opioid agonist-induced activation of G-protein-coupled inwardly rectifying potassium current in rat periaqueductal gray neurons , 1999, Neuroscience.

[193]  E. J. Simon,et al.  Role of Protein Kinase C (PKC) in Agonist‐Induced α‐Opioid Receptor Down‐Regulation , 1999 .

[194]  Y. Daaka,et al.  Delta opioid receptors expressed by stably transfected jurkat cells signal through the map kinase pathway in a ras-independent manner , 1999, Journal of Neuroimmunology.

[195]  E. J. Simon,et al.  Role of protein kinase C (PKC) in agonist-induced mu-opioid receptor down-regulation: I. PKC translocation to the membrane of SH-SY5Y neuroblastoma cells is induced by mu-opioid agonists. , 1999, Journal of neurochemistry.

[196]  Y. Wong,et al.  Stimulation of phospholipase C by the cloned μ, δ and κ opioid receptors via chimeric Gαq mutants , 1999, The European journal of neuroscience.

[197]  M. Caron,et al.  Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. , 1999, Science.

[198]  L. Bohn,et al.  Requirement of Receptor Internalization for Opioid Stimulation of Mitogen-Activated Protein Kinase: Biochemical and Immunofluorescence Confocal Microscopic Evidence , 1999, The Journal of Neuroscience.

[199]  Kenneth A. Jones,et al.  GABAB receptors function as a heteromeric assembly of the subunits GABABR1 and GABABR2 , 1998, Nature.

[200]  R. Shigemoto,et al.  GABAB-receptor subtypes assemble into functional heteromeric complexes , 1998, Nature.

[201]  Y. Kurachi,et al.  G protein regulation of potassium ion channels. , 1998, Pharmacological reviews.

[202]  S. P. Schneider,et al.  Opioid-activated postsynaptic, inward rectifying potassium currents in whole cell recordings in substantia gelatinosa neurons. , 1998, Journal of neurophysiology.

[203]  W. J. Tang,et al.  Chronic morphine augments adenylyl cyclase phosphorylation: relevance to altered signaling during tolerance/dependence. , 1998, Molecular pharmacology.

[204]  B. Hille,et al.  G-Protein β-Subunit Specificity in the Fast Membrane-Delimited Inhibition of Ca2+ Channels , 1998, The Journal of Neuroscience.

[205]  M. Marrero,et al.  Regulation of angiotensin II-induced JAK2 tyrosine phosphorylation: roles of SHP-1 and SHP-2. , 1998, American journal of physiology. Cell physiology.

[206]  T. Wong,et al.  Phospholipase C inhibitors attenuate arrhythmias induced by kappa-receptor stimulation in the isolated rat heart. , 1998, Journal of molecular and cellular cardiology.

[207]  W. J. Tang,et al.  Chronic morphine augments G(beta)(gamma)/Gs(alpha) stimulation of adenylyl cyclase: relevance to opioid tolerance. , 1998, Molecular pharmacology.

[208]  M. von Zastrow,et al.  Phosphorylation Is Not Required for Dynamin-dependent Endocytosis of a Truncated Mutant Opioid Receptor* , 1998, The Journal of Biological Chemistry.

[209]  C. Barnes,et al.  Dynamic Regulation of RGS2 Suggests a Novel Mechanism in G-Protein Signaling and Neuronal Plasticity , 1998, The Journal of Neuroscience.

[210]  A. Gingras,et al.  μ-Opioid Receptor Activates Signaling Pathways Implicated in Cell Survival and Translational Control* , 1998, The Journal of Biological Chemistry.

[211]  B. Hawes,et al.  Nociceptin (ORL‐1) and μ‐Opioid Receptors Mediate Mitogen‐Activated Protein Kinase Activation in CHO Cells Through a Gi‐Coupled Signaling Pathway: Evidence for Distinct Mechanisms of Agonist‐Mediated Desensitization , 1998, Journal of neurochemistry.

[212]  J. Whistler,et al.  Morphine-activated opioid receptors elude desensitization by β-arrestin , 1998 .

[213]  S. Rees,et al.  Hydrophobicity of residue351 of the G protein Gi1 alpha determines the extent of activation by the alpha 2A-adrenoceptor. , 1998, Biochemistry.

[214]  J. Hurley,et al.  Catalytic mechanism and regulation of mammalian adenylyl cyclases. , 1998, Molecular pharmacology.

[215]  Robert J. Lefkowitz,et al.  G Protein-coupled Receptors , 1998, The Journal of Biological Chemistry.

[216]  P. Leff,et al.  Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: evidence for agonist-directed trafficking of receptor stimulus. , 1998, Molecular pharmacology.

[217]  H. Loh,et al.  Distinct Differences Between Morphine‐ and [d‐Ala2,N‐MePhe4,Gly‐ol5]‐Enkephalin‐ μ‐Opioid Receptor Complexes Demonstrated by Cyclic AMP‐Dependent Protein Kinase Phosphorylation , 1998, Journal of neurochemistry.

[218]  M. Caron,et al.  Role for G protein-coupled receptor kinase in agonist-specific regulation of mu-opioid receptor responsiveness. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[219]  H. Loh,et al.  Contribution of phospholipase C-beta3 phosphorylation to the rapid attenuation of opioid-activated phosphoinositide response. , 1998, Molecular pharmacology.

[220]  M. Comb,et al.  A Mitogen-activated Protein Kinase Pathway Is Required for μ-Opioid Receptor Desensitization* , 1998, The Journal of Biological Chemistry.

[221]  Y. Sarne,et al.  Dissociation between the inhibitory and stimulatory effects of opioid peptides on cAMP formation in SK-N-SH neuroblastoma cells. , 1998, Biochemical and biophysical research communications.

[222]  E. Stefani,et al.  Functional coupling between human E‐type Ca2+ channels and μ opioid receptors expressed in Xenopus oocytes , 1998, FEBS letters.

[223]  D. McKean,et al.  Signaling through Delta Opioid Receptors on Murine Splenic T Cells and Stably Transfected Jurkat Cells , 1998, Annals of the New York Academy of Sciences.

[224]  Y. Wong,et al.  Differential Coupling of μ‐, δ‐, and κ‐Opioid Receptors to Gα16‐Mediated Stimulation of Phospholipase C , 1998 .

[225]  P. Sánchez-Blázquez,et al.  delta Opioid receptor subtypes activate inositol-signaling pathways in the production of antinociception. , 1998, The Journal of pharmacology and experimental therapeutics.

[226]  S. Shenolikar,et al.  The β2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange , 1998, Nature.

[227]  S. Sealfon,et al.  Rhodopsin-family receptors associate with small G proteins to activate phospholipase D , 1998, Nature.

[228]  M. Peyton,et al.  Multiple neurological abnormalities in mice deficient in the G protein Go. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[229]  V. Höllt,et al.  Opioid withdrawal activates MAP kinase in locus coeruleus neurons in morphine‐dependent rats in vivo , 1998, The European journal of neuroscience.

[230]  A. Hsu,et al.  TAN-67, a δ1-opioid receptor agonist, reduces infarct size via activation of Gi/o proteins and KATP channels. , 1998, American journal of physiology. Heart and circulatory physiology.

[231]  D. Hilgemann,et al.  Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gβγ , 1998, Nature.

[232]  Z. Vogel,et al.  Opioid Modulation of Extracellular Signal‐Regulated Protein Kinase Activity Is Ras‐Dependent and Involves Gβγ Subunits , 1998 .

[233]  G. Pei,et al.  Suppression of phospholipase C blocks Gi-mediated inhibition of adenylyl cyclase activity. , 1998, European journal of pharmacology.

[234]  G. Pei,et al.  Inhibition of phospholipase C blocks opioid receptor‐mediated activation of Gi proteins , 1998, Neuroreport.

[235]  V. Hruby,et al.  Opioid Peptides: Simultaneous δ Agonism and μ Antagonism in Somatostatin Analogues , 1997, Peptides.

[236]  K. Kalli,et al.  Delta-opioid receptors expressed by Jurkat T cells enhance IL-2 secretion by increasing AP-1 complexes and activity of the NF-AT/AP-1-binding promoter element. , 1997, Journal of immunology.

[237]  S. Appleyard,et al.  Agonist‐Induced Phosphorylation of the κ‐Opioid Receptor , 1997 .

[238]  R. Schulz,et al.  Enhanced stimulatory adenylyl cyclase signaling during opioid dependence is associated with a reduction in palmitoylated Gs alpha. , 1997, Molecular pharmacology.

[239]  G. Uhl,et al.  μ Opioid Receptor Phosphorylation, Desensitization, and Ligand Efficacy* , 1997, The Journal of Biological Chemistry.

[240]  G. Pei,et al.  Modulation by calcium/calmodulin-dependent protein kinase II of functional response of delta opioid receptor in neuroblastoma x glioma hybrid (NG108-15) cells , 1997, Neuropharmacology.

[241]  L. Devi,et al.  Dimerization of the delta opioid receptor: implication for a role in receptor internalization. , 1997, The Journal of biological chemistry.

[242]  R. J. Spencer,et al.  Mobilization of Ca2+ from intracellular stores in transfected neuro2a cells by activation of multiple opioid receptor subtypes. , 1997, Biochemical pharmacology.

[243]  T. Kroslak,et al.  Site Mutation in the Rat μ‐Opioid Receptor Demonstrates the Involvement of Calcium/Calmodulin‐Dependent Protein Kinase II in Agonist‐Mediated Desensitization , 1997, Journal of neurochemistry.

[244]  L. Pu,et al.  Etorphine inhibits cell growth and induces apoptosis in SK-N-SH cells: involvement of pertussis toxin-sensitive G proteins , 1997, Neuroscience Research.

[245]  M. Marrero,et al.  Dependence on the Motif YIPP for the Physical Association of Jak2 Kinase with the Intracellular Carboxyl Tail of the Angiotensin II AT1 Receptor* , 1997, The Journal of Biological Chemistry.

[246]  G. Milligan,et al.  Agonist-mediated tyrosine phosphorylation of isoforms of the shc adapter protein by the delta opioid receptor. , 1997, Cellular signalling.

[247]  Emiko Suzuki,et al.  A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade , 1997, Nature.

[248]  G. Milligan,et al.  Mitogenic signalling by delta opioid receptors expressed in rat-1 fibroblasts involves activation of the p70s6k/p85s6k S6 kinase. , 1997, The Biochemical journal.

[249]  S. Law,et al.  Changes in the association of G protein subunits with the cloned mouse delta opioid receptor on agonist stimulation. , 1997, The Journal of pharmacology and experimental therapeutics.

[250]  C. Kuhn,et al.  Differential effects of naltrindole on morphine-induced tolerance and physical dependence in rats. , 1997, The Journal of pharmacology and experimental therapeutics.

[251]  Y. Jan,et al.  Binding of the G protein βγ subunit to multiple regions of G protein‐gated inward‐rectifying K+ channels , 1997 .

[252]  N. Akaike,et al.  Modulation of high-voltage activated Ca2+ channels in the rat periaqueductal gray neurons by mu-type opioid agonist. , 1997, Journal of neurophysiology.

[253]  K. Hirota,et al.  The effects of recombinant rat μ‐opioid receptor activation in CHO cells on phospholipase C, [Ca2+]i and adenylyl cyclase , 1997, British journal of pharmacology.

[254]  Z. Vogel,et al.  Opiate-induced Adenylyl Cyclase Superactivation Is Isozyme-specific* , 1997, The Journal of Biological Chemistry.

[255]  W. Catterall,et al.  Molecular determinants of inactivation and G protein modulation in the intracellular loop connecting domains I and II of the calcium channel α1A subunit , 1997 .

[256]  S. Allouche,et al.  The δ‐Opioid Receptor Regulates Activity of Ryanodine Receptors in the Human Neuroblastoma Cell Line SK‐N‐BE , 1996, Journal of neurochemistry.

[257]  G. Milligan,et al.  Agonist activation of p42 and p44 mitogen-activated protein kinases following expression of the mouse delta opioid receptor in Rat-1 fibroblasts: effects of receptor expression levels and comparisons with G-protein activation. , 1996, The Biochemical journal.

[258]  K. Shen,et al.  Modulatory effects of Gs-coupled excitatory opioid receptor functions on opioid analgesia, tolerance, and dependence , 1996, Neurochemical Research.

[259]  J. Benovic,et al.  β-Arrestin acts as a clathrin adaptor in endocytosis of the β2-adrenergic receptor , 1996, Nature.

[260]  G. Makhlouf,et al.  Opioid mu, delta, and kappa receptor-induced activation of phospholipase C-beta 3 and inhibition of adenylyl cyclase is mediated by Gi2 and G(o) in smooth muscle. , 1996, Molecular pharmacology.

[261]  T. Hales,et al.  Voltage-dependent inhibition of Ca2+ channels in GH3 cells by cloned mu- and delta-opioid receptors. , 1996, Molecular pharmacology.

[262]  K. Chang,et al.  The stimulatory effect of opioids on mitogen-activated protein kinase in Chinese hamster ovary cells transfected to express mu-opioid receptors. , 1996, Molecular pharmacology.

[263]  K. Fukuda,et al.  Functional Coupling of the δ‐, μ‐, and κ‐Opioid Receptors to Mitogen‐Activated Protein Kinase and Arachidonate Release in Chinese Hamster Ovary Cells , 1996 .

[264]  Z. Vogel,et al.  Chronic Opioid Treatment Induces Adenylyl Cyclase V Superactivation , 1996, The Journal of Biological Chemistry.

[265]  Christopher J. Evans,et al.  Morphine Activates Opioid Receptors without Causing Their Rapid Internalization* , 1996, The Journal of Biological Chemistry.

[266]  K. Yan,et al.  A Domain on the G Protein β Subunit Interacts with Both Adenylyl Cyclase 2 and the Muscarinic Atrial Potassium Channel* , 1996, The Journal of Biological Chemistry.

[267]  R. Miller,et al.  Mechanism of inhibition of calcium channels in rat nucleus tractus solitarius by neurotransmitters , 1996, British journal of pharmacology.

[268]  D. Lambert,et al.  Tyr-D-Arg2-Phe-sarcosine4 activates phospholipase C-coupled mu2-opioid receptors in SH-SY5Y cells. , 1996, European journal of pharmacology.

[269]  F. F. Weight,et al.  Differential Opiate Receptor Phosphorylation and Desensitization Induced by Agonists and Phorbol Esters (*) , 1996, The Journal of Biological Chemistry.

[270]  R. Stephens,et al.  Structural Requirements of Heparin Binding to Chlamydia trachomatis(*) , 1996, The Journal of Biological Chemistry.

[271]  K. Mackie,et al.  Modulation of Ca2+ channels by G-protein βγ subunits , 1996, Nature.

[272]  S. Ikeda.  Voltage-dependent modulation of N-type calcium channels by G-protein β γsubunits , 1996, Nature.

[273]  K. Mackie,et al.  Modulation of Ca2+ channels βγ G-protein py subunits , 1996, Nature.

[274]  T. Soong,et al.  Determinants of the G protein-dependent opioid modulation of neuronal calcium channels. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[275]  D. Lawrence,et al.  Precision Substrate Targeting of Protein Kinases , 1996, The Journal of Biological Chemistry.

[276]  M. Connor,et al.  δ‐ and μ‐opioid receptor mobilization of intracellular calcium in SH‐SY5Y human neuroblastoma cells , 1996 .

[277]  M. Olianas,et al.  Participation of delta opioid receptor subtypes in the stimulation of adenylyl cyclase activity in rat olfactory bulb. , 1995, The Journal of pharmacology and experimental therapeutics.

[278]  Y. Wong,et al.  Activation of Type II Adenylyl Cyclase by the Cloned μ‐Opioid Receptor: Coupling to Multiple G Proteins , 1995, Journal of neurochemistry.

[279]  T. Coderre,et al.  Attenuation of morphine tolerance and dependence with the highly selective δ-opioid receptor antagonist TIPP[ψ] , 1995 .

[280]  Y. Jan,et al.  Evidence that direct binding of Gβγ to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation , 1995, Neuron.

[281]  W. Sadee,et al.  Phosphorylation and Agonist‐Specific Intracellular Trafficking of an Epitope‐Tagged μ‐Opioid Receptor Expressed in HEK 293 Cells , 1995, Journal of neurochemistry.

[282]  M. Satoh,et al.  Molecular biology of the opioid receptors: structures, functions and distributions , 1995, Neuroscience Research.

[283]  K. Fukuda,et al.  Coupling of the Cloned μ‐Opioid Receptor with the ω‐Conotoxin‐Sensitive Ca2+ Current in NG108‐15 Cells , 1995 .

[284]  D. Lambert,et al.  Mu-opioid activation of phospholipase C in SH-SY5Y cells rapidly desensitizes: mechanistic studies. , 1995, Biochemical Society transactions.

[285]  H. Ueda,et al.  Opioid μ- and κ-receptor mediate phospholipase C activation through Gi1 in Xenopus oocytes , 1995 .

[286]  R. Lefkowitz,et al.  Agonist-dependent phosphorylation of the mouse delta-opioid receptor: involvement of G protein-coupled receptor kinases but not protein kinase C. , 1995, Molecular pharmacology.

[287]  J. Kiang,et al.  Antisense oligodeoxynucleotide to the Gi2 protein alpha subunit sequence inhibits an opioid-induced increase in the intracellular free calcium concentration in ND8-47 neuroblastoma x dorsal root ganglion hybrid cells. , 1995, Molecular pharmacology.

[288]  M. Simon,et al.  Gα15 and Gα16 Couple a Wide Variety of Receptors to Phospholipase C (*) , 1995, The Journal of Biological Chemistry.

[289]  H. Loh,et al.  Expression of the μ‐Opioid Receptor in CHO Cells: Ability of μ‐Opioid Ligands to Promote α‐Azidoanilido[32P]GTP Labeling of Multiple G Protein α Subunits , 1995 .

[290]  Y. Wong,et al.  Regulation of Multiple Effectors by the Cloned δ‐Opioid Receptor: Stimulation of Phospholipase C and Type II Adenylyl Cyclase , 1995, Journal of neurochemistry.

[291]  R. Stoffel,et al.  A region of adenylyl cyclase 2 critical for regulation by G protein beta gamma subunits. , 1995, Science.

[292]  H. Loh,et al.  Ca2+ channel and adenylyl cyclase modulation by cloned mu-opioid receptors in GH3 cells. , 1995, Molecular pharmacology.

[293]  A. Kuznetsov,et al.  kappa-Opioid receptor activates an inwardly rectifying K+ channel by a G protein-linked mechanism: coexpression in Xenopus oocytes. , 1995, Molecular pharmacology.

[294]  H. Loh,et al.  Properties of a κ-opioid receptor expressed in CHO cells: interaction with multiple G-proteins is not specific for any individual Gα subunit and is similar to that of other opioid receptors , 1995 .

[295]  T. Katada,et al.  A subtype of opioid κ‐receptor is coupled to inhibition of Gil‐mediated phospholipase C activity in the guinea pig cerebellum , 1995, FEBS letters.

[296]  D. Grandy,et al.  Kappa-opioid receptors couple to inwardly rectifying potassium channels when coexpressed by Xenopus oocytes. , 1995, Molecular pharmacology.

[297]  N. Davidson,et al.  A G protein-gated K channel is activated via beta 2-adrenergic receptors and G beta gamma subunits in Xenopus oocytes , 1995, The Journal of general physiology.

[298]  Y. Wong,et al.  GZ coupling to the rat κ‐opioid receptor , 1995 .

[299]  D. Lambert,et al.  Mu-opioids activate phospholipase C in SH-SY5Y human neuroblastoma cells via calcium-channel opening. , 1995, The Biochemical journal.

[300]  H. Rhim,et al.  Opioid receptors modulate diverse types of calcium channels in the nucleus tractus solitarius of the rat , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[301]  H. Loh,et al.  Ability of delta-opioid receptors to interact with multiple G-proteins is independent of receptor density. , 1994, The Journal of biological chemistry.

[302]  C. Kozak,et al.  Murine Chromosomal Location of the μ and κ Opioid Receptor Genes , 1994 .

[303]  P P Humphrey,et al.  International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). , 1994, Pharmacological reviews.

[304]  R. Macdonald,et al.  mu-Opioid receptor-mediated reduction of neuronal calcium current occurs via a G(o)-type GTP-binding protein , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[305]  H. Loh,et al.  Interaction of delta-opioid receptors with multiple G proteins: a non-relationship between agonist potency to inhibit adenylyl cyclase and to activate G proteins. , 1994, Molecular pharmacology.

[306]  D. Clapham,et al.  Recombinant G-protein βγ-subunits activate the muscarinic-gated atrial potassium channel , 1994, Nature.

[307]  D. Lambert,et al.  μ‐Opioid Receptor Stimulation of Inositol (1,4,5)Trisphosphate Formation via a Pertussis Toxin‐Sensitive G Protein , 1994, Journal of neurochemistry.

[308]  R. Taussig,et al.  Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases. , 1994, The Journal of biological chemistry.

[309]  D. Kaufman,et al.  Localization of the δ-Opioid Receptor Gene to Mouse Chromosome 4 by Linkage Analysis , 1994 .

[310]  J. Williams,et al.  kappa-Opioid receptors also increase potassium conductance. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[311]  A Goldstein,et al.  Cloning and pharmacological characterization of a rat kappa opioid receptor. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[312]  Lei Yu,et al.  Molecular cloning and functional expression of a mu opioid receptor from rat brain , 1994, Regulatory Peptides.

[313]  B. Carter,et al.  Go mediates the coupling of the mu opioid receptor to adenylyl cyclase in cloned neural cells and brain. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[314]  H. Loh,et al.  Opioid-induced inhibition of voltage-gated calcium channels parallels expression of ω-conotoxin-sensitive channel subtype during differentiation of NG108-15 cells , 1993, Brain Research.

[315]  B. Dvorkin,et al.  Direct coupling of opioid receptors to both stimulatory and inhibitory guanine nucleotide-binding proteins in F-11 neuroblastoma-sensory neuron hybrid cells. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[316]  G. Dawson,et al.  Opioid peptides activate phospholipase D and protein kinase C-epsilon in chicken embryo neuron cultures. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[317]  F. Okajima,et al.  Enkephalin activates the phospholipase C/Ca2+ system through cross-talk between opioid receptors and P2-purinergic or bradykinin receptors in NG 108-15 cells. A permissive role for pertussis toxin-sensitive G-proteins. , 1993, The Biochemical journal.

[318]  R. Edwards,et al.  Cloning of a delta opioid receptor by functional expression. , 1992, Science.

[319]  K. Befort,et al.  The delta-opioid receptor: isolation of a cDNA by expression cloning and pharmacological characterization. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[320]  H. Loh,et al.  Dual excitatory and inhibitory effects of opioids on intracellular calcium in neuroblastoma x glioma hybrid NG108-15 cells. , 1992, Molecular pharmacology.

[321]  C. Aoki,et al.  Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family. , 1992, The Journal of biological chemistry.

[322]  G. Schultz,et al.  Different β-subunits determine G-protein interaction with transmembrane receptors , 1992, Nature.

[323]  H. Loh,et al.  Identification of three separate guanine nucleotide-binding proteins that interact with the delta-opioid receptor in NG108-15 neuroblastoma x glioma hybrid cells. , 1992, Molecular pharmacology.

[324]  B. Conklin,et al.  Hormonal stimulation of adenylyl cyclase through Gi-protein βγ subunits , 1992, Nature.

[325]  B. Conklin,et al.  Gz-mediated hormonal inhibition of cyclic AMP accumulation. , 1992, Science.

[326]  G. Schultz,et al.  Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents , 1991, Nature.

[327]  P. Portoghese,et al.  Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice. , 1991, The Journal of pharmacology and experimental therapeutics.

[328]  G. Schultz,et al.  Evidence for opioid receptor-mediated activation of the G-proteins, Go and Gi2, in membranes of neuroblastoma x glioma (NG108-15) hybrid cells. , 1991, The Journal of biological chemistry.

[329]  Frank McCormick,et al.  The GTPase superfamily: a conserved switch for diverse cell functions , 1990, Nature.

[330]  M. Caron,et al.  beta-Arrestin: a protein that regulates beta-adrenergic receptor function. , 1990, Science.

[331]  G. Milligan,et al.  Delta-opioid-receptor-mediated inhibition of adenylate cyclase is transduced specifically by the guanine-nucleotide-binding protein Gi2. , 1990, The Biochemical journal.

[332]  J. Axelrod,et al.  Serotonin stimulates phospholipase A2 and the release of arachidonic acid in hippocampal neurons by a type 2 serotonin receptor that is independent of inositolphospholipid hydrolysis. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[333]  A. Herz,et al.  Sodium modulates opioid receptors through a membrane component different from G-proteins. Demonstration by target size analysis. , 1988, The Journal of biological chemistry.

[334]  P. Portoghese,et al.  Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays. , 1988, The Journal of pharmacology and experimental therapeutics.

[335]  B. Dvorkin,et al.  Modulation of adenylate cyclase activity of mouse spinal cord-ganglion explants by opioids, serotonin and pertussis toxin , 1988, Brain Research.

[336]  P. Portoghese,et al.  Naltrindole, a highly selective and potent non-peptide δ opioid receptor antagonist , 1988 .

[337]  J T Williams,et al.  Mu and delta receptors belong to a family of receptors that are coupled to potassium channels. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[338]  G. Schultz,et al.  The GTP-binding protein, Go9 regulates neuronal calcium channels , 1987, Nature.

[339]  F. Tirone,et al.  Pertussis toxin inhibits the antinociceptive action of morphine in the rat. , 1986, European journal of pharmacology.

[340]  H. Loh,et al.  Involvement of Both Inhibitory and Stimulatory Guanine Nucleotide Binding Proteins in the Expression of Chronic Opiate Regulation of Adenylate Cyclase Activity in NG108‐15 Cells , 1985, Journal of neurochemistry.

[341]  M. Luján,et al.  Pertussis toxin blocks the action of morphine, norepinephrine and clonidine on isolated guinea-pig ileum. , 1984, European journal of pharmacology.

[342]  E. Hewlett,et al.  ADP-ribosylation of adenylate cyclase by pertussis toxin. Effects on inhibitory agonist binding. , 1984, The Journal of biological chemistry.

[343]  T. Katada,et al.  Specific uncoupling by islet-activating protein, pertussis toxin, of negative signal transduction via alpha-adrenergic, cholinergic, and opiate receptors in neuroblastoma x glioma hybrid cells. , 1983, The Journal of biological chemistry.

[344]  R. Barrett,et al.  The effects of receptor selective opioid peptides on morphine-induced analgesia. , 1982, European journal of pharmacology.

[345]  P. Portoghese,et al.  Pharmacological characterization in vivo of the novel opiate, beta-funaltrexamine. , 1982, The Journal of pharmacology and experimental therapeutics.

[346]  P. Cuatrecasas,et al.  Interactions of ligands with morphine and enkephalin receptors are differentially affected by guanine nucleotide. , 1981, Molecular pharmacology.

[347]  J. Wu,et al.  Demonstration and Characterization of Opiate Inhibition of the Striatal Adenylate Cyclase , 1981, Journal of neurochemistry.

[348]  D. L. Larson,et al.  The irreversible narcotic antagonistic and reversible agonistic properties of the fumaramate methyl ester derivative of naltrexone. , 1981, European journal of pharmacology.

[349]  A. Goldstein,et al.  Immunoreactive dynorphin in pituitary and brain. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[350]  C. Chavkin,et al.  A specific radioimmunoassay for the novel opioid peptide dynorphin. , 1980, Life sciences.

[351]  R. Schulz,et al.  Selective development of tolerance without dependence in multiple opiate receptors of mouse vas deferens , 1980, Nature.

[352]  A. Blume,et al.  Coupling of opiate receptors to adenylate cyclase: requirement for Na+ and GTP. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[353]  P. Cuatrecasas,et al.  Multiple opiate receptors: different regional distribution in the brain and differential binding of opiates and opioid peptides. , 1979, Molecular pharmacology.

[354]  N. Flesness,et al.  Kinship asymmetry in diploids , 1978, Nature.

[355]  Choh Hao Li,et al.  ISOLATION, STRUCTURE, SYNTHESIS AND MORPHINE‐LIKE ACTIVITY OF β‐ENDORPHIN FROM HUMAN PITUITARY GLANDS * , 1977, Annals of the New York Academy of Sciences.

[356]  M. Nirenberg,et al.  Opiate-dependent modulation of adenylate cyclase. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[357]  John Hughes,et al.  Endogenous opioid peptides: multiple agonists and receptors , 1977, Nature.

[358]  H. Loh,et al.  beta-endorphin is a potent analgesic agent. , 1976, Proceedings of the National Academy of Sciences of the United States of America.

[359]  J. Thompson,et al.  The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog. , 1976, The Journal of pharmacology and experimental therapeutics.

[360]  H. Morris,et al.  Identification of two related pentapeptides from the brain with potent opiate agonist activity , 1975, Nature.

[361]  H. Collier,et al.  Morphine abstinence is associated with increased brain cyclic AMP , 1975, Nature.

[362]  L. Volicer,et al.  Effect of morphine sulfate on adenylate cyclase and phosphodiesterase activities in rat corpus striatum. , 1975, Life sciences.

[363]  M. Nirenberg,et al.  Morphine receptors as regulators of adenylate cyclase activity. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[364]  H. Collier,et al.  Morphine-like drugs inhibit the stimulation by E prostaglandins of cyclic AMP formation by rat brain homogenate , 1974, Nature.

[365]  S. Snyder,et al.  Properties of opiate-receptor binding in rat brain. , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[366]  E. J. Simon,et al.  Stereospecific binding of the potent narcotic analgesic (3H) Etorphine to rat-brain homogenate. , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[367]  A. Goldstein,et al.  Stereospecific and nonspecific interactions of the morphine congener levorphanol in subcellular fractions of mouse brain. , 1971, Proceedings of the National Academy of Sciences of the United States of America.

[368]  Z. Vogel,et al.  Adenylyl cyclase type-VIII activity is regulated by Gβγ subunits , 2006 .

[369]  A. López-Fando,et al.  Expression of Neural RGS-R7 and Gβ5 Proteins in Response to Acute and Chronic Morphine , 2005, Neuropsychopharmacology.

[370]  L. Devi,et al.  Opioid Receptor Oligomerization , 2003 .

[371]  D. Witherow,et al.  A Novel Kind of G Protein Heterodimer: The Gβ5-RGS Complex , 2003 .

[372]  S. Rhee,et al.  Regulation of phosphoinositide-specific phospholipase C. , 2001, Annual review of biochemistry.

[373]  G. Dawson,et al.  Multiple polyphosphoinositide pathways regulate apoptotic signalling in a dorsal root ganglion derived cell line , 2000, Journal of neuroscience research.

[374]  H. Loh,et al.  Molecular mechanisms and regulation of opioid receptor signaling. , 2000, Annual review of pharmacology and toxicology.

[375]  E M Ross,et al.  GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins. , 2000, Annual review of biochemistry.

[376]  E. J. Simon,et al.  Role of protein kinase C (PKC) in agonist-induced mu-opioid receptor down-regulation: II. Activation and involvement of the alpha, epsilon, and zeta isoforms of PKC. , 1999, Journal of neurochemistry.

[377]  D. Mangoura,et al.  Diversity of the endogenous opioid system in development. Novel signal transduction translates multiple extracellular signals into neural cell growth and differentiation. , 1998, Perspectives on developmental neurobiology.

[378]  H. Loh,et al.  Agonist Activation of δ-Opioid Receptor but not μ-Opioid Receptor Potentiates Fetal Calf Serum or Tyrosine Kinase Receptor-Mediated Cell Proliferation in a CellLine-Specific Manner , 1997 .

[379]  B. Conklin,et al.  Gz-mediated inhibition of cAMP accumulation , 1992 .

[380]  K. Aktories,et al.  Pertussis toxin decreases opiate receptor binding and adenylate inhibition in a neuroblastoma x glioma hybrid cell line. , 1983, Life sciences.

[381]  A. Takemori,et al.  Differential effects of leucine and methionine enkephalin on morphine-induced analgesia, acute tolerance and dependence. , 1979, The Journal of pharmacology and experimental therapeutics.

[382]  H. Loh,et al.  3H-Leu5-enkephalin specific binding to synaptic membrane-comparison with 3H-dihydromorphine and 3H-naloxone. , 1978, Research communications in chemical pathology and pharmacology.