Research Article Determination of Rizatriptan Benzoate in Bulk and Tablets by Spectrophotometry

This paper describes a visible spectrophotometric method for quantitative analysis of rizatriptan benzoate (RTB) using vanillin. The absorbance measurements were performed analyzing the colored complex (λmax=579 nm) produced from the reaction between RTB and vanillin in acid medium. The experimental variables were optimized in order to obtain the best reaction conditions. These variables included concentration of sulphuric acid and vanillin. The linearity was studied in the range of 50250 μg/ml with a regression coefficient of 0.9997. The limit of detection and limit of quantification was estimated to be 0.156 and 0.472 μg/ml, respectively. The RTB content in commercial samples were analyzed using the proposed method and the results were favorably compared with those of the reported UV spectrophotometric method, showing that quantitative analysis by visible spectrophotometric method using vanillin could be effectively used to determine rizatriptan benzoate in tablet dosage forms.

[1]  G. Senthilkumar,et al.  DETERMINATION OF RIZATRIPTAN IN BULK AND ITS TABLET DOSAGE FORMS BY UV SPECTROSCOPIC METHOD , 2011 .

[2]  S. Lahoti,et al.  Spectrophotometric Estimation of Rizatriptan Benzoate , 2010 .

[3]  Sahoo Subhasish,et al.  UV-SPECTROSCOPIC METHODS FOR ESTIMATION OF RIZATRIPTAN BENZOATE IN PHARMACEUTICAL PREPARATIONS , 2010 .

[4]  E. Oga.  SPECTROPHOTOMETRIC DETERMINATION OF ISONIAZID IN PURE AND PHARMACEUTICAL FORMULATIONS USING VANILLIN , 2010 .

[5]  K. Ramakrishna,et al.  New spectrophotometric methods for the estimation of Lercanidipine hydrochloride , 2009 .

[6]  M. Zečević,et al.  Application of Multicriteria Methodology in the Development of Improved RP-LC-DAD for Determination of Rizatriptan and Its Degradation Products , 2008 .

[7]  M. Zečević,et al.  A Chemometrical Approach to Optimization and Validation of an HPLC Assay for Rizatriptan and its Impurities in Tablets , 2007 .

[8]  D. Sankar,et al.  Visible Spectrophotometric Methods For The Determination Of Rizatriptan In Pure Form And In Pharmaceutical Formulations , 2007 .

[9]  G. Fan,et al.  Development and validation of a selective and robust LC-MS/MS method for high-throughput quantifying rizatriptan in small plasma samples: application to a clinical pharmacokinetic study. , 2006, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[10]  M. Láinez.  Rizatriptan in the treatment of migraine , 2006, Neuropsychiatric disease and treatment.

[11]  Yu Qin.  Determination of rizatriptan in human plasma by RP-HPLC with fluorescence detection , 2006 .

[12]  Xin-guo Jiang,et al.  Liquid chromatographic method for the determination of rizatriptan in human plasma. , 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[13]  S. Altinoz,et al.  DETERMINATION OF RIZATRIPTAN IN ITS TABLET DOSAGE FORMS BY UV SPECTROPHOTOMETRIC AND SPECTROFLUORIMETRIC METHODS , 2002 .

[14]  K. Altria,et al.  Quantitative microemulsion electrokinetic capillary chromatography analysis of formulated drug products , 2001 .

[15]  S. Dax,et al.  Solid-phase Mannich condensation of amines, aldehydes, and alkynes: investigation of diverse aldehyde inputs. , 2001, Journal of combinatorial chemistry.

[16]  M. Bartlett,et al.  Determination of antimigraine compounds rizatriptan, zolmitriptan, naratriptan and sumatriptan in human serum by liquid chromatography/electrospray tandem mass spectrometry. , 2000, Rapid communications in mass spectrometry : RCM.

[17]  B. Matuszewski,et al.  Disposition and pharmacokinetics of the antimigraine drug, rizatriptan, in humans. , 2000, Drug metabolism and disposition: the biological fate of chemicals.

[18]  D. Faulds,et al.  Rizatriptan , 1999, Drugs.

[19]  W. Brode,et al.  CONDENSATIONS OF SECONDARY AMINES WITH NAPHTHOLS AND ALDEHYDES. II , 1931 .

[20]  W. Brode,et al.  CONDENSATIONS OF SECONDARY AMINES WITH ALDEHYDES AND NAPHTHOLS1 , 1930 .