Human cancers express mutator phenotypes: origin, consequences and targeting

[1]  J. Licht,et al.  DNMT3A mutations in acute myeloid leukemia , 2011, Nature Genetics.

[2]  Michael A. Choti,et al.  DAXX/ATRX, MEN1, and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors , 2011, Science.

[3]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[4]  Trevor J Pugh,et al.  Initial genome sequencing and analysis of multiple myeloma , 2011, Nature.

[5]  R. Wood,et al.  DNA polymerases and cancer , 2011, Nature Reviews Cancer.

[6]  Zev A. Binder,et al.  The Genetic Landscape of the Childhood Cancer Medulloblastoma , 2011, Science.

[7]  N. Carter,et al.  Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development , 2011, Cell.

[8]  Eric S. Lander,et al.  The genomic complexity of primary human prostate cancer , 2010, Nature.

[9]  P. A. Futreal,et al.  Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma , 2010, Nature.

[10]  H. Lehrach,et al.  Somatic Mutation Profiles of MSI and MSS Colorectal Cancer Identified by Whole Exome Next Generation Sequencing and Bioinformatics Analysis , 2010, PloS one.

[11]  M. Nowak,et al.  Distant Metastasis Occurs Late during the Genetic Evolution of Pancreatic Cancer , 2010, Nature.

[12]  Tian-Li Wang,et al.  Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma , 2010, Science.

[13]  C. Cazaux,et al.  Aberrant expression of alternative DNA polymerases: a source of mutator phenotype as well as replicative stress in cancer. , 2010, Seminars in cancer biology.

[14]  L. Loeb,et al.  Lethal mutagenesis: targeting the mutator phenotype in cancer. , 2010, Seminars in cancer biology.

[15]  L. Loeb,et al.  Active Site Mutations in Mammalian DNA Polymerase δ Alter Accuracy and Replication Fork Progression* , 2010, Journal of Biological Chemistry.

[16]  Jan Lubinski,et al.  Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[17]  A. Chambers,et al.  Extracellular matrix: a gatekeeper in the transition from dormancy to metastatic growth. , 2010, European journal of cancer.

[18]  A. Sparks,et al.  The mutation spectrum revealed by paired genome sequences from a lung cancer patient , 2010, Nature.

[19]  P. Shannon,et al.  Analysis of Genetic Inheritance in a Family Quartet by Whole-Genome Sequencing , 2010, Science.

[20]  Joshua F. McMichael,et al.  Genome Remodeling in a Basal-like Breast Cancer Metastasis and Xenograft , 2010, Nature.

[21]  L. Loeb,et al.  Mutational heterogeneity in human cancers: origin and consequences. , 2010, Annual review of pathology.

[22]  E. Birney,et al.  A small cell lung cancer genome reports complex tobacco exposure signatures , 2009, Nature.

[23]  Tom Royce,et al.  A comprehensive catalogue of somatic mutations from a human cancer genome , 2010, Nature.

[24]  Gurpreet W. Tang,et al.  Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes , 2009, Nature.

[25]  R. Prayson,et al.  Mutational Heterogeneity in Human Cancers : Origin and Consequences , 2010 .

[26]  A. Børresen-Dale,et al.  COMPLEX LANDSCAPES OF SOMATIC REARRANGEMENT IN HUMAN BREAST CANCER GENOMES , 2009, Nature.

[27]  A. Ashworth,et al.  Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. , 2009, The New England journal of medicine.

[28]  M. Bronner,et al.  Clonal expansions in ulcerative colitis identify patients with neoplasia , 2009, Proceedings of the National Academy of Sciences.

[29]  Ryan D. Morin,et al.  Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution , 2009, Nature.

[30]  R. Goldsby,et al.  DNA polymerase ε and δ proofreading suppress discrete mutator and cancer phenotypes in mice , 2009, Proceedings of the National Academy of Sciences.

[31]  Ken Chen,et al.  Recurring mutations found by sequencing an acute myeloid leukemia genome. , 2009, The New England journal of medicine.

[32]  L. Loeb,et al.  High fidelity and lesion bypass capability of human DNA polymerase delta. , 2009, Biochimie.

[33]  Jesse J Salk,et al.  Cancer genome sequencing--an interim analysis. , 2009, Cancer research.

[34]  J. Ramser,et al.  Identification of brain- and bone-specific breast cancer metastasis genes. , 2009, Cancer letters.

[35]  P. Hanawalt,et al.  Intrinsic genomic instability from naturally occurring DNA structures: An introduction to the special issue , 2009, Molecular Carcinogenesis.

[36]  T. Ragg,et al.  Perioperative activation of disseminated tumor cells in bone marrow of patients with prostate cancer. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[37]  C. Klein,et al.  Parallel progression of primary tumours and metastases , 2009, Nature Reviews Cancer.

[38]  J. Vijg,et al.  DNA structure-induced genomic instability in vivo. , 2008, Journal of the National Cancer Institute.

[39]  P. Hanawalt,et al.  Transcription-coupled DNA repair: two decades of progress and surprises , 2008, Nature Reviews Molecular Cell Biology.

[40]  G. Parmigiani,et al.  Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers , 2008, Proceedings of the National Academy of Sciences.

[41]  Amy E. Hawkins,et al.  DNA sequencing of a cytogenetically normal acute myeloid leukemia genome , 2008, Nature.

[42]  Brian H. Dunford-Shore,et al.  Somatic mutations affect key pathways in lung adenocarcinoma , 2008, Nature.

[43]  G. Parmigiani,et al.  Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses , 2008, Science.

[44]  D. Busam,et al.  An Integrated Genomic Analysis of Human Glioblastoma Multiforme , 2008, Science.

[45]  M. Stratton,et al.  Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing , 2008, Proceedings of the National Academy of Sciences.

[46]  L. Loeb,et al.  DNA polymerases and human disease , 2008, Nature Reviews Genetics.

[47]  Robert A Beckman,et al.  Genetic instability is not a requirement for tumor development. , 2008, Cancer research.

[48]  Odd O Aalen,et al.  Breast cancer tumor growth estimated through mammography screening data , 2008, Breast Cancer Research.

[49]  Derek Y. Chiang,et al.  Characterizing the cancer genome in lung adenocarcinoma , 2007, Nature.

[50]  A. Sparks,et al.  The Genomic Landscapes of Human Breast and Colorectal Cancers , 2007, Science.

[51]  C. Sarkar,et al.  Clonal mutations in primary human glial tumors: evidence in support of the mutator hypothesis , 2007, BMC Cancer.

[52]  D. Lin,et al.  Fen1 mutations result in autoimmunity, chronic inflammation and cancers , 2007, Nature Medicine.

[53]  Juno Choe,et al.  Highly Tolerated Amino Acid Substitutions Increase the Fidelity of Escherichia coli DNA Polymerase I* , 2007, Journal of Biological Chemistry.

[54]  E. Birney,et al.  Patterns of somatic mutation in human cancer genomes , 2007, Nature.

[55]  Lawrence D True,et al.  Human cancers express a mutator phenotype , 2006, Proceedings of the National Academy of Sciences.

[56]  L. Loeb,et al.  Efficiency of carcinogenesis with and without a mutator mutation , 2006, Proceedings of the National Academy of Sciences.

[57]  S. Nishimura 8-Hydroxyguanine: From its discovery in 1983 to the present status , 2006, Proceedings of the Japan Academy. Series B, Physical and biological sciences.

[58]  Hongyue Dai,et al.  Gene expression changes associated with progression and response in chronic myeloid leukemia. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[59]  L. Loeb,et al.  Mutator Phenotypes Caused by Substitution at a Conserved Motif A Residue in Eukaryotic DNA Polymerase δ* , 2006, Journal of Biological Chemistry.

[60]  G. Collins The next generation. , 2006, Scientific American.

[61]  E. Friedberg,et al.  DNA Repair and Mutagenesis , 2006 .

[62]  L. Loeb,et al.  Negative Clonal Selection in Tumor Evolution , 2005, Genetics.

[63]  Andrew D. Yates,et al.  A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer , 2005, Nature Genetics.

[64]  J. Bielas,et al.  Quantification of random genomic mutations , 2005, Nature Methods.

[65]  R. Preston Mechanistic data and cancer risk assessment: The need for quantitative molecular endpoints , 2005, Environmental and molecular mutagenesis.

[66]  Z. Livneh,et al.  Quantitative Analysis of Translesion DNA Synthesis across a Benzo[a]pyrene-Guanine Adduct in Mammalian Cells , 2004, Journal of Biological Chemistry.

[67]  Juno Choe,et al.  Protein tolerance to random amino acid change. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[68]  J. Sweasy,et al.  Is There a Link Between DNA Polymerase Beta and Cancer? , 2004, Cell cycle.

[69]  Carissa A. Sanchez,et al.  Selectively Advantageous Mutations and Hitchhikers in Neoplasms , 2004, Cancer Research.

[70]  Seyed E. Hasnain,et al.  Extensive Intra-tumor Heterogeneity in Primary Human Glial Tumors as a Result of Locus Non-specific Genomic Alterations , 2000, Journal of Neuro-Oncology.

[71]  P. Armitage,et al.  The Age Distribution of Cancer and a Multi-stage Theory of Carcinogenesis , 1954, British Journal of Cancer.

[72]  M. King,et al.  Breast and Ovarian Cancer Risks Due to Inherited Mutations in BRCA1 and BRCA2 , 2003, Science.

[73]  D. Albertson,et al.  Chromosome aberrations in solid tumors , 2003, Nature Genetics.

[74]  R. Eils,et al.  From latent disseminated cells to overt metastasis: Genetic analysis of systemic breast cancer progression , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[75]  L. Prakash,et al.  Role of human DNA polymerase κ as an extender in translesion synthesis , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[76]  R. Solé,et al.  Metapopulation dynamics and spatial heterogeneity in cancer , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[77]  Booncharoen Sirinaovakul,et al.  Introduction to the Special Issue , 2002, Comput. Intell..

[78]  Kyungjae Myung,et al.  Maintenance of Genome Stability in Saccharomyces cerevisiae , 2002, Science.

[79]  R. Larson,et al.  Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study. , 2002, Blood.

[80]  Giovanni Parmigiani,et al.  Prevalence of somatic alterations in the colorectal cancer cell genome , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[81]  F. Hanaoka,et al.  Translesion DNA Synthesis Catalyzed by Human Pol η and Pol κ across 1,N 6-Ethenodeoxyadenosine* , 2001, The Journal of Biological Chemistry.

[82]  R. Goldsby,et al.  Defective DNA polymerase-δ proofreading causes cancer susceptibility in mice , 2001, Nature Medicine.

[83]  C. Sawyers,et al.  Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. , 2001, The New England journal of medicine.

[84]  P. May,et al.  Cell cycle control and cancer. , 2000, Pathologie-biologie.

[85]  P. Duesberg,et al.  Aneuploidy vs. gene mutation hypothesis of cancer: recent study claims mutation but is found to support aneuploidy. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[86]  K. Loeb,et al.  Significance of multiple mutations in cancer. , 2000, Carcinogenesis.

[87]  T. Lindahl,et al.  Quality control by DNA repair. , 1999, Science.

[88]  S. Hecht,et al.  Tobacco smoke carcinogens and lung cancer. , 1999, Journal of the National Cancer Institute.

[89]  Chikahide Masutani,et al.  The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η , 1999, Nature.

[90]  J. Mullins,et al.  Lethal mutagenesis of HIV with mutagenic nucleoside analogs. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[91]  S Srivastava,et al.  A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. , 1998, Cancer research.

[92]  D. Lane,et al.  The p53 tumour suppressor gene , 1998, The British journal of surgery.

[93]  Amanda G Paulovich,et al.  When Checkpoints Fail , 1997, Cell.

[94]  L. Aaltonen,et al.  Somatic microsatellite mutations as molecular tumor clocks , 1996, Nature Medicine.

[95]  P. Modrich,et al.  Mismatch repair in replication fidelity, genetic recombination, and cancer biology. , 1996, Annual review of biochemistry.

[96]  T. Kunkel,et al.  Error-prone replication of repeated DNA sequences by T7 DNA polymerase in the absence of its processivity subunit. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[97]  P. Jones,et al.  The rate of hydrolytic deamination of 5-methylcytosine in double-stranded DNA. , 1994, Nucleic acids research.

[98]  M. Stratton,et al.  Instability of short tandem repeats (microsatellites) in human cancers , 1994, Nature Genetics.

[99]  A. Berchuck,et al.  Genetic instability of microsatellites in endometrial carcinoma. , 1993, Cancer research.

[100]  M. Eigen Viral quasi species. , 1993 .

[101]  Darryl Shibata,et al.  Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis , 1993, Nature.

[102]  S N Thibodeau,et al.  Microsatellite instability in cancer of the proximal colon. , 1993, Science.

[103]  K. Kinzler,et al.  Clues to the pathogenesis of familial colorectal cancer. , 1993, Science.

[104]  A. Balmain,et al.  How many mutations are required for tumorigenesis? implications from human cancer data , 1993 .

[105]  Loss of chromosomal integrity in neoplasia. , 1993, Cold Spring Harbor symposia on quantitative biology.

[106]  M. Eigen,et al.  Viral quasispecies. , 1993, Scientific American.

[107]  G. Riethmüller,et al.  Monoclonal antibodies in the detection and therapy of micrometastatic epithelial cancers , 1992, Current Biology.

[108]  A. Velázquez,et al.  Isolation and characterization of allelic losses and gains in colorectal tumors by arbitrarily primed polymerase chain reaction. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[109]  L. Loeb,et al.  A DNA polymerase alpha pause site is a hot spot for nucleotide misinsertion. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[110]  L. Loeb,et al.  Mutagenic spectrum resulting from DNA damage by oxygen radicals. , 1991, Biochemistry.

[111]  David A. Steinhauer,et al.  Mutation Frequencies at Defined Single Codon Sites in Vesicular Stomatitis Virus and Poliovirus Can Be Increased Only Slightly by Chemical Mutagenesis , 1990, Journal of virology.

[112]  Robert C. Wolpert,et al.  A Review of the , 1985 .

[113]  G. Heppner,et al.  Mutagenic activity of tumor-associated macrophages in Salmonella typhimurium strains TA98 and TA 100. , 1984, Cancer research.

[114]  G. Heppner Tumor heterogeneity. , 1984, Cancer research.

[115]  I. Fidler,et al.  Biological and experimental consequences of the zonal composition of solid tumors. , 1981, Cancer research.

[116]  P. Nowell The clonal evolution of tumor cell populations. , 1976, Science.

[117]  L. Loeb,et al.  Errors in DNA replication as a basis of malignant changes. , 1974, Cancer research.

[118]  F. Mitelman,et al.  Tumor Etiology and Chromosome Pattern , 1972, Science.

[119]  L. Foulds The experimental study of tumor progression: a review. , 1954, Cancer research.