Retina imaging in vivo with the adaptive optics confocal scanning laser ophthalmoscope

An adaptive optics confocal scanning laser ophthalmoscope (AOSLO) for retina imaging is devoloped in this paper. By using a wavefront sensor (Shack-Hartmann wavefront sensor with 11×11 lenslet array) to measure aberrations of human eye and a wavefront compensator (37-channel PZT deformable mirror) to correct for the aberrations, the AOSLO system can acquire near diffraction-limited image of human retina over the whole field of view (1×1 degree ~ 3×3 degree). The imaging frequency is 30Hz, which provides a real-time observation of human cone mosaic in vivo. The system has potential application in early disease diagnose and vision research.