SERTAD1 initiates NLRP3-mediated inflammasome activation through restricting NLRP3 polyubiquitination.

[1]  V. G. Magupalli,et al.  Cryo-EM structures of the active NLRP3 inflammasome disc , 2022, Nature.

[2]  Gabriel Núñez,et al.  The NLRP3 inflammasome: activation and regulation. , 2022, Trends in biochemical sciences.

[3]  E. Latz,et al.  How location and cellular signaling combine to activate the NLRP3 inflammasome , 2022, Cellular & Molecular Immunology.

[4]  R. Flavell,et al.  GSK3β mediates the spatiotemporal dynamics of NLRP3 inflammasome activation , 2022, Cell Death & Differentiation.

[5]  J. Mansfield,et al.  Regulation and Role of αE Integrin and Gut Homing Integrins in Migration and Retention of Intestinal Lymphocytes during Inflammatory Bowel Disease , 2021, The Journal of Immunology.

[6]  T. Kang,et al.  NLRP3 Ubiquitination—A New Approach to Target NLRP3 Inflammasome Activation , 2021, International journal of molecular sciences.

[7]  T. Kanneganti,et al.  NLRP3 inflammasome in cancer and metabolic diseases , 2021, Nature Immunology.

[8]  J. P. de Rivero Vaccari,et al.  Role of inflammasomes in multiple sclerosis and their potential as therapeutic targets , 2020, Journal of neuroinflammation.

[9]  Murugesan V. S. Rajaram,et al.  Sequential ubiquitination of NLRP3 by RNF125 and Cbl-b limits inflammasome activation and endotoxemia , 2020, The Journal of experimental medicine.

[10]  J. Ting,et al.  The NLRP3 inflammasome: molecular activation and regulation to therapeutics , 2019, Nature Reviews Immunology.

[11]  Yang Xiao,et al.  ABRO1 promotes NLRP3 inflammasome activation through regulation of NLRP3 deubiquitination , 2019, The EMBO journal.

[12]  F. Liu,et al.  Cullin1 binds and promotes NLRP3 ubiquitination to repress systematic inflammasome activation , 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[13]  L. Magder,et al.  Association between changes in gene signatures expression and disease activity among patients with systemic lupus erythematosus , 2019, BMC Medical Genomics.

[14]  Inhwa Hwang,et al.  Brefeldin A–sensitive ER‐Golgi vesicle trafficking contributes to NLRP3‐dependent caspase‐1 activation , 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[15]  D. Ye,et al.  NLRP3: A promising therapeutic target for autoimmune diseases. , 2018, Autoimmunity reviews.

[16]  P. Moynagh,et al.  The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome , 2018, Nature Communications.

[17]  Ryouta Kamata,et al.  ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages , 2017, The Journal of Immunology.

[18]  S. Park,et al.  A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1 , 2017, Nature Cell Biology.

[19]  Jiahuai Han,et al.  Protein kinase D at the Golgi controls NLRP3 inflammasome activation , 2017, The Journal of experimental medicine.

[20]  H. Steller,et al.  The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoforms , 2017, eLife.

[21]  M. Shinohara,et al.  Inflammasome activation in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE) , 2017, Brain pathology.

[22]  S. Park,et al.  The deubiquitinating enzyme, ubiquitin‐specific peptidase 50, regulates inflammasome activation by targeting the ASC adaptor protein , 2017, FEBS letters.

[23]  Jing Zhao,et al.  The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3 , 2016, Nature Communications.

[24]  G. Núñez,et al.  Nek7 is an essential mediator of NLRP3 activation downstream of potassium efflux , 2016, Nature.

[25]  Chuan-Qi Zhong,et al.  Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion , 2015, Cell Research.

[26]  B. Beutler,et al.  NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component , 2015, Nature Immunology.

[27]  T. Cai,et al.  Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death , 2015, Nature.

[28]  Haitao Guo,et al.  Inflammasomes: mechanism of action, role in disease, and therapeutics , 2015, Nature Medicine.

[29]  Bill B. Chen,et al.  Lipopolysaccharide Primes the NALP3 Inflammasome by Inhibiting Its Ubiquitination and Degradation Mediated by the SCFFBXL2 E3 Ligase* , 2015, The Journal of Biological Chemistry.

[30]  Lei Liu,et al.  Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome , 2015, Cell.

[31]  J. Bienkowska,et al.  Lymphotoxin-LIGHT Pathway Regulates the Interferon Signature in Rheumatoid Arthritis , 2014, PloS one.

[32]  P. Li,et al.  Inflammatory caspases are innate immune receptors for intracellular LPS , 2014, Nature.

[33]  Young Yang,et al.  Distinct regulatory effect of the p34SEI-1 oncoprotein on cancer metastasis in HER2/neu-positive and -negative cells. , 2014, International journal of oncology.

[34]  Katherine A. Fitzgerald,et al.  Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes , 2014, Cell.

[35]  Zhijian J. Chen,et al.  Prion-like Polymerization Underlies Signal Transduction in Antiviral Immune Defense and Inflammasome Activation , 2014, Cell.

[36]  Young Yang,et al.  Oncogenic function of p34SEI-1 via NEDD4‑1‑mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway. , 2013, International journal of oncology.

[37]  Adam Santaniello,et al.  Blood RNA profiling in a large cohort of multiple sclerosis patients and healthy controls. , 2013, Human molecular genetics.

[38]  M. T. Wong,et al.  Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4 , 2013, Science.

[39]  Daniel E. Zak,et al.  Caspase-11 Protects Against Bacteria That Escape the Vacuole , 2013, Science.

[40]  Junying Yuan,et al.  Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity. , 2013, Molecular cell.

[41]  E. Alnemri,et al.  Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation* , 2012, The Journal of Biological Chemistry.

[42]  M. Shinohara,et al.  NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis , 2012, Proceedings of the National Academy of Sciences.

[43]  Jinfeng Liu,et al.  Non-canonical inflammasome activation targets caspase-11 , 2011, Nature.

[44]  Seung-Woo Hong,et al.  p34SEI-1 inhibits ROS-induced cell death through suppression of ASK1 , 2011, Cancer biology & therapy.

[45]  N. Nishimoto,et al.  Underexpression of mitochondrial-DNA encoded ATP synthesis-related genes and DNA repair genes in systemic lupus erythematosus , 2011, Arthritis research & therapy.

[46]  Grace Y Chen,et al.  Sterile inflammation: sensing and reacting to damage , 2010, Nature Reviews Immunology.

[47]  Seung-Woo Hong,et al.  p34SEI-1 Inhibits Doxorubicin-Induced Senescence through a Pathway Mediated by Protein Kinase C-δ and c-Jun-NH2-Kinase 1 Activation in Human Breast Cancer MCF7 Cells , 2009, Molecular Cancer Research.

[48]  G. Núñez,et al.  Cutting Edge: TNF-α Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation1 , 2009, The Journal of Immunology.

[49]  E. Alnemri,et al.  Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression1 , 2009, The Journal of Immunology.

[50]  Seung-Woo Hong,et al.  p34SEI-1 inhibits apoptosis through the stabilization of the X-linked inhibitor of apoptosis protein: p34SEI-1 as a novel target for anti-breast cancer strategies. , 2009, Cancer research.

[51]  Ya-Li Yao,et al.  Transcriptional and subcellular regulation of the TRIP-Br family. , 2007, Gene.

[52]  R. Mayer,et al.  Ubiquitin and ubiquitin-like proteins as multifunctional signals , 2005, Nature Reviews Molecular Cell Biology.

[53]  Yixin Zeng,et al.  Oncogenic transformation by SEI-1 is associated with chromosomal instability. , 2005, Cancer research.

[54]  G. Núñez,et al.  Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC. , 2004, The Journal of biological chemistry.

[55]  F. Martinon,et al.  NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. , 2004, Immunity.

[56]  M. Pagano,et al.  Role of the SCFSkp2 Ubiquitin Ligase in the Degradation of p21Cip1 in S Phase* , 2003, Journal of Biological Chemistry.

[57]  F. Martinon,et al.  The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. , 2002, Molecular cell.

[58]  D. Scott,et al.  New mutations of CIAS1 that are responsible for Muckle-Wells syndrome and familial cold urticaria: a novel mutation underlies both syndromes. , 2002, American journal of human genetics.

[59]  J. Bonventre,et al.  TRIP‐Br: a novel family of PHD zinc finger‐ and bromodomain‐interacting proteins that regulate the transcriptional activity of E2F‐1/DP‐1 , 2001, The EMBO journal.

[60]  I. Hampson,et al.  Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1). , 1999, Genes & development.

[61]  J. Tschopp,et al.  The Inflammasomes , 2010, Cell.