Two Naturally Occurring Terpenes, Dehydrocostuslactone and Costunolide, Decrease Intracellular GSH Content and Inhibit STAT3 Activation
暂无分享,去创建一个
H. Yamazaki | Yasuo Watanabe | Elena Butturini | A. Carcereri de Prati | S. Mariotto | Hisanori Suzuki | N. Murayama | E. Cavalieri | E. Darra | A. Rigo | K. Shoji
[1] A. Mantovani,et al. Inflammatory bowel disease and intestinal cancer: a paradigm of the Yin–Yang interplay between inflammation and cancer , 2010, Oncogene.
[2] M. Huang,et al. Oxidative and endoplasmic reticulum stress signaling are involved in dehydrocostuslactone-mediated apoptosis in human non-small cell lung cancer cells. , 2010, Lung cancer.
[3] Xiaomin Chen,et al. STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells. , 2010, Blood.
[4] Hua Yu,et al. STATs in cancer inflammation and immunity: a leading role for STAT3 , 2009, Nature Reviews Cancer.
[5] E. Tsai,et al. Dehydrocostuslactone disrupts signal transducers and activators of transcription 3 through up-regulation of suppressor of cytokine signaling in breast cancer cells , 2009, Molecular Cancer Therapeutics.
[6] P. Kuo,et al. Dehydrocostuslactone, a Medicinal Plant-Derived Sesquiterpene Lactone, Induces Apoptosis Coupled to Endoplasmic Reticulum Stress in Liver Cancer Cells , 2009, Journal of Pharmacology and Experimental Therapeutics.
[7] M. Pazin,et al. S-glutathionylation impairs signal transducer and activator of transcription 3 activation and signaling. , 2009, Endocrinology.
[8] Sylvia Notenboom,et al. Glutathione dysregulation and the etiology and progression of human diseases , 2009, Biological chemistry.
[9] M. Neurath,et al. Signaling molecules: the pathogenic role of the IL-6/STAT-3 trans signaling pathway in intestinal inflammation and in colonic cancer. , 2008, Current drug targets.
[10] E. Mazzon,et al. Protective effect of Arbutus unedo aqueous extract in carrageenan-induced lung inflammation in mice. , 2008, Pharmacological research.
[11] Roberto Colombo,et al. Molecular mechanisms and potential clinical significance of S-glutathionylation. , 2008, Antioxidants & redox signaling.
[12] D. Sohn,et al. Costunolide inhibits production of tumor necrosis factor-α and interleukin-6 by inducing heme oxygenase-1 in RAW264.7 macrophages , 2007, Inflammation Research.
[13] S. Rane,et al. Hematopoietic cytokine receptor signaling , 2007, Oncogene.
[14] D. Levy,et al. JAK-STAT Signaling: From Interferons to Cytokines* , 2007, Journal of Biological Chemistry.
[15] Nam-Song Kim,et al. The alpha-methylene-gamma-butyrolactone moiety in dehydrocostus lactone is responsible for cytoprotective heme oxygenase-1 expression through activation of the nuclear factor E2-related factor 2 in HepG2 cells. , 2007, European journal of pharmacology.
[16] S. Rastogi,et al. Saussurea costus: botanical, chemical and pharmacological review of an ayurvedic medicinal plant. , 2007, Journal of ethnopharmacology.
[17] E. Mazzon,et al. EFFECTS OF HYPERICUM PERFORATUM EXTRACT IN A RAT MODEL OF ISCHEMIA AND REPERFUSION INJURY , 2005, Shock.
[18] S. Mariotto,et al. STAT1 as a new molecular target of anti-inflammatory treatment. , 2005, Current medicinal chemistry.
[19] R. Sitia,et al. Stress, Protein (Mis)folding, and Signaling: The Redox Connection , 2004, Science's STKE.
[20] J. Gardin,et al. 1041-98 Epigallocatechin-3-gallate inhibits stat-1 activation and protects cardiac myocytes from ischemia/reperfusion-induced apoptosis , 2004 .
[21] J. Ha,et al. Costunolide Triggers Apoptosis in Human Leukemia U937 Cells by Depleting Intracellular Thiols , 2002, Japanese journal of cancer research : Gann.
[22] Jing Wen,et al. Oxidative Stress-mediated Apoptosis , 2002, The Journal of Biological Chemistry.
[23] R. Jove,et al. Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.
[24] J. H. Park,et al. Costunolide induces apoptosis by ROS-mediated mitochondrial permeability transition and cytochrome C release. , 2001, Biological & pharmaceutical bulletin.
[25] Young-Soo Hong,et al. A Sesquiterpene Lactone, Costunolide, from Magnolia grandiflora Inhibits NF-κB by Targeting IκB Phosphorylation , 2001 .
[26] N. Holbrook,et al. Oxidants, oxidative stress and the biology of ageing , 2000, Nature.
[27] Pavel Kovarik,et al. Serine phosphorylation of STATs , 2000, Oncogene.
[28] D. Wedge,et al. Fungicidal activity of natural and synthetic sesquiterpene lactone analogs. , 2000, Phytochemistry.
[29] H. Pahl,et al. Inhibition of transcription factor NF-kappaB by sesquiterpene lactones: a proposed molecular mechanism of action. , 1999, Bioorganic & medicinal chemistry.
[30] Xinmin Cao,et al. Serine Phosphorylation and Negative Regulation of Stat3 by JNK* , 1999, The Journal of Biological Chemistry.
[31] D. Sohn,et al. A sesquiterpene, dehydrocostus lactone, inhibits the expression of inducible nitric oxide synthase and TNF-alpha in LPS-activated macrophages. , 1999, Planta medica.
[32] J. Darnell,et al. Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3. , 1997, Nucleic acids research.
[33] T. Schmidt,et al. Helenanolide-type sesquiterpene lactones--III. Rates and stereochemistry in the reaction of helenalin and related helenanolides with sulfhydryl containing biomolecules. , 1997, Bioorganic & medicinal chemistry.
[34] J. Darnell,et al. Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation , 1995, Cell.
[35] J. Darnell,et al. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. , 1994, Science.
[36] G. Nabel,et al. Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[37] O. Griffith,et al. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. , 1980, Analytical biochemistry.
[38] M. M. Bradford. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.
[39] P. Marchetti,et al. Protective effects of St. John's wort extract and its component hyperforin against cytokine-induced cytotoxicity in a pancreatic beta-cell line. , 2008, The international journal of biochemistry & cell biology.
[40] T. Hirano,et al. IL-6 signal transduction and its physiological roles: the signal orchestration model. , 2003, Reviews of physiology, biochemistry and pharmacology.
[41] J. Lee,et al. A sesquiterpene lactone, costunolide, from Magnolia grandiflora inhibits NF-kappa B by targeting I kappa B phosphorylation. , 2001, Planta medica.