Clinical evaluation of a new artificial saliva in spray form for patients with dry mouth.

OBJECTIVES To determine the efficacy of a new saliva substitute in spray form, for patients with dry mouth. STUDY DESIGN Thirty-seven patients with dry mouth were selected (16 males and 21 females), with an age of over 60 years and meeting the following inclusion criteria: xerostomia and hyposialia confirmed by sialometry (resting whole saliva / stimulated whole saliva). A new artificial saliva in spray format was applied, with evaluation of the degree of improvement (VAS scale), frequency of application, time to improvement in minutes, duration in minutes, and assessment of organoleptic properties. RESULTS Twenty of the 37 patients showed almost immediate improvement after application. The mean number of applications/day was 3.89, with a mean duration of effect of 15.3 min. (65% > 15 min.). The flavor was rated as pleasant by 18 patients. CONCLUSIONS Application of the spray is simple and effective, affording immediate relief, and with reasonable acceptance among patients with dry mouth.

[1]  J. M. Gallardo.  Xerostomía: etiología, diagnóstico y tratamiento , 2008 .

[2]  J. Gallardo.  [Xerostomia: etiology, diagnosis and treatment]. , 2008, Revista medica del Instituto Mexicano del Seguro Social.

[3]  J. Guggenheimer,et al.  Medication-induced hyposalivation: etiology, diagnosis, and treatment. , 2008, Compendium of continuing education in dentistry.

[4]  M. Brosky.  The role of saliva in oral health: strategies for prevention and management of xerostomia. , 2007, The journal of supportive oncology.

[5]  C. Flaitz,et al.  Role of remineralizing fluid in in vitro enamel caries formation and progression. , 2007, Quintessence international.

[6]  D. Aframian,et al.  Pilocarpine treatment in a mixed cohort of xerostomic patients. , 2007, Oral diseases.

[7]  C. Turssi,et al.  Rehardening of caries-like lesions in root surfaces by saliva substitutes. , 2006, Gerodontology.

[8]  H. Meyer-Lueckel,et al.  Effect of various Ca2+/PO4(3-) concentrations of linseed-based saliva substitutes on enamel in vitro. , 2006, Journal of oral rehabilitation.

[9]  C. Llena-Puy.  The rôle of saliva in maintaining oral health and as an aid to diagnosis. , 2006, Medicina oral, patologia oral y cirugia bucal.

[10]  S. Challacombe,et al.  Impact of wearing an intra-oral lubricating device on oral health in dry mouth patients. , 2006, Oral diseases.

[11]  C. Fowler,et al.  Review of the use of polymers in saliva substitutes for symptomatic relief of xerostomia. , 2006, The Journal of clinical dentistry.

[12]  Peter Bottenberg,et al.  [Saliva substitutes]. , 2006, Revue belge de medecine dentaire.

[13]  Elisabeth Wärnberg Gerdin,et al.  Impact of dry mouth conditions on oral health-related quality of life in older people. , 2005, Gerodontology.

[14]  J. Roh,et al.  Xerostomia following radiotherapy of the head and neck affects vocal function. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[15]  F. Silvestre-Donat,et al.  Protocol for the clinical management of dry mouth. , 2004, Medicina oral : organo oficial de la Sociedad Espanola de Medicina Oral y de la Academia Iberoamericana de Patologia y Medicina Bucal.

[16]  J. Guggenheimer,et al.  Xerostomia: etiology, recognition and treatment. , 2003, Journal of the American Dental Association.

[17]  P. Frost.  Difficulties in dental prescribing of saliva substitutes for xerostomia. , 2002, Gerodontology.

[18]  B. Marple,et al.  Dry mouth and nose in the older patient. What every PCP should know. , 2002, Geriatrics.

[19]  Hay Kd,et al.  Xerostomia and you. , 2002 .

[20]  S. Pillemer,et al.  Xerostomia and the Geriatric Patient , 2002, Journal of the American Geriatrics Society.

[21]  K. Hay,et al.  Xerostomia and you. , 2002, The New Zealand dental journal.

[22]  J. Epstein,et al.  Quality of life and oral function in patients treated with radiation therapy for head and neck cancer , 2001, Head & neck.

[23]  B. GuijarroGuijarro,et al.  Treatment of xerostomia. A review. , 2001 .

[24]  T. Nederfors.  Xerostomia and Hyposalivation , 2000, Advances in dental research.

[25]  J. Bergdahl,et al.  Low Unstimulated Salivary Flow and Subjective Oral Dryness: Association with Medication, Anxiety, Depression, and Stress , 2000, Journal of dental research.

[26]  P. Fox.  Management of dry mouth. , 1997, Dental clinics of North America.

[27]  C. S. Pifarré,et al.  La prescripción de farmacos en el paciente anciano: Implicaciones en odonto-estomatologia , 1993 .

[28]  T. Daniels,et al.  Salivary and oral components of Sjögren's syndrome. , 1992, Rheumatic diseases clinics of North America.

[29]  L. Sreebny.  Recognition and treatment of salivary induced conditions. , 1989, International dental journal.