Phenotype, donor age and gender affect function of human bone marrow-derived mesenchymal stromal cells

[1]  O. Lindvall,et al.  Regulation of stem cell therapies under attack in Europe: for whom the bell tolls , 2013, The EMBO journal.

[2]  H. Northoff,et al.  Mesenchymal stromal/stem cells markers in the human bone marrow. , 2013, Cytotherapy.

[3]  C. Choong,et al.  MSCs into adipogenic, chondrogenic, and osteogenic lineages identify markers and signaling pathways important in differentiation of growth of mesenchymal stem cells (MSCs): transcriptional profiling can , and FGF signaling is important for differentiation and β PDGF, TGF- , 2013 .

[4]  R. Schäfer.  Does the adult stroma contain stem cells? , 2013, Advances in biochemical engineering/biotechnology.

[5]  D. Phinney.  Functional heterogeneity of mesenchymal stem cells: Implications for cell therapy , 2012, Journal of cellular biochemistry.

[6]  M. Reinders,et al.  A Mesenchymal Stromal Cell Gene Signature for Donor Age , 2012, PloS one.

[7]  P. Giannoudis,et al.  Transcriptional profile of native CD271+ multipotential stromal cells: evidence for multiple fates, with prominent osteogenic and Wnt pathway signaling activity. , 2012, Arthritis and rheumatism.

[8]  A. Ignatius,et al.  Platelet lysate from whole blood-derived pooled platelet concentrates and apheresis-derived platelet concentrates for the isolation and expansion of human bone marrow mesenchymal stromal cells: production process, content and identification of active components , 2012, Cytotherapy.

[9]  C. V. van Blitterswijk,et al.  Therapeutic applications of mesenchymal stromal cells: paracrine effects and potential improvements. , 2012, Tissue engineering. Part B, Reviews.

[10]  H. Northoff,et al.  Bone marrow-derived human mesenchymal stem cells express cardiomyogenic proteins but do not exhibit functional cardiomyogenic differentiation potential. , 2012, Stem cells and development.

[11]  P. Giannoudis,et al.  High abundance of CD271+ multipotential stromal cells (MSCs) in intramedullary cavities of long bones , 2012, Bone.

[12]  David H. Miller,et al.  Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study , 2012, The Lancet Neurology.

[13]  Jacques Galipeau,et al.  Human MSC suppression correlates with cytokine induction of indoleamine 2,3-dioxygenase and bystander M2 macrophage differentiation. , 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

[14]  Katie C. Russell,et al.  Clonal analysis of the proliferation potential of human bone marrow mesenchymal stem cells as a function of potency , 2011, Biotechnology and bioengineering.

[15]  L. Prantl,et al.  Estrogen reduces cellular aging in human mesenchymal stem cells and chondrocytes , 2011, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[16]  J. Hare,et al.  Mesenchymal stem cells: biology, pathophysiology, translational findings, and therapeutic implications for cardiac disease. , 2011, Circulation research.

[17]  M. Petrini,et al.  Mesodermal Progenitor Cells (MPCs) Differentiate into Mesenchymal Stromal Cells (MSCs) by Activation of Wnt5/Calmodulin Signalling Pathway , 2011, PloS one.

[18]  V. Krishnappa,et al.  Fibroblast Growth Factor 2 (Fgf2) Inhibits Differentiation of Mesenchymal Stem Cells by Inducing Twist2 and Spry4, Blocking Extracellular Regulated Kinase Activation, and Altering Fgf Receptor Expression Levels , 2011, Stem cells.

[19]  D. Coutu,et al.  Inhibition of cellular senescence by developmentally regulated FGF receptors in mesenchymal stem cells. , 2011, Blood.

[20]  M. Matthay,et al.  Concise Review: Mesenchymal Stem Cells for Acute Lung Injury: Role of Paracrine Soluble Factors , 2011, Stem cells.

[21]  H. Northoff,et al.  Expression of blood group genes by mesenchymal stem cells , 2011, British journal of haematology.

[22]  A. Luttun,et al.  Differentiation Potential of Human Postnatal Mesenchymal Stem Cells, Mesoangioblasts, and Multipotent Adult Progenitor Cells Reflected in Their Transcriptome and Partially Influenced by the Culture Conditions , 2011, Stem cells.

[23]  David H. Miller,et al.  The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments , 2011, Trials.

[24]  J. Kim,et al.  Enhanced proliferation and chondrogenic differentiation of human synovium-derived stem cells expanded with basic fibroblast growth factor. , 2011, Tissue engineering. Part A.

[25]  Kristen E. Pauken,et al.  The role of the PD‐1 pathway in autoimmunity and peripheral tolerance , 2011, Annals of the New York Academy of Sciences.

[26]  C. Schiff,et al.  Galectin-1-expressing stromal cells constitute a specific niche for pre-BII cell development in mouse bone marrow. , 2011, Blood.

[27]  R. Handgretinger,et al.  Human multipotent mesenchymal stromal cells use galectin-1 to inhibit immune effector cells. , 2010, Blood.

[28]  M. Kalmanti,et al.  Comparative study of stemness characteristics of mesenchymal cells from bone marrow of children and adults. , 2010, Cytotherapy.

[29]  D. Hommes,et al.  Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study , 2010, Gut.

[30]  Katie C. Russell,et al.  In Vitro High‐Capacity Assay to Quantify the Clonal Heterogeneity in Trilineage Potential of Mesenchymal Stem Cells Reveals a Complex Hierarchy of Lineage Commitment , 2010, Stem cells.

[31]  J. Tardif,et al.  Improved Function and Myocardial Repair of Infarcted Heart by Intracoronary Injection of Mesenchymal Stem Cell-Derived Growth Factors , 2010, Journal of cardiovascular translational research.

[32]  H. Atkins,et al.  The therapeutic potential of mesenchymal stem cell transplantation as a treatment for multiple sclerosis: consensus report of the International MSCT Study Group , 2010, Multiple sclerosis.

[33]  S. Du,et al.  Autocrine BMP4 signaling involves effect of cholesterol myristate on proliferation of mesenchymal stem cells , 2009, Steroids.

[34]  M. Selig,et al.  Immunomodulatory Function of Bone Marrow-Derived Mesenchymal Stem Cells in Experimental Autoimmune Type 1 Diabetes1 , 2009, The Journal of Immunology.

[35]  P. Conte,et al.  Heterogeneity of Multipotent Mesenchymal Stromal Cells: From Stromal Cells to Stem Cells and Vice Versa , 2009, Transplantation.

[36]  F. Dazzi,et al.  The Immunosuppressive Properties of Mesenchymal Stem Cells , 2009, Transplantation.

[37]  L. Kanz,et al.  Isolation of functionally distinct mesenchymal stem cell subsets using antibodies against CD56, CD271, and mesenchymal stem cell antigen-1 , 2009, Haematologica.

[38]  恒吉 法尋.  PRDM14 suppresses expression of differentiation marker genes in human embryonic stem cells , 2009 .

[39]  D. Strunk,et al.  Basic research and clinical applications of non-hematopoietic stem cells, 4-5 April 2008, Tubingen, Germany. , 2009, Cytotherapy.

[40]  N. LeBrasseur,et al.  Effects of dihydrotestosterone on differentiation and proliferation of human mesenchymal stem cells and preadipocytes , 2008, Molecular and Cellular Endocrinology.

[41]  A. Keating,et al.  Bone Marrow-derived Mesenchymal Stromal Cells Express Cardiac-specific Markers, Retain the Stromal Phenotype, and Do Not Become Functional Cardiomyocytes in Vitro Departments of a Physiology And , 2022 .

[42]  N. Nardi,et al.  In Search of the In Vivo Identity of Mesenchymal Stem Cells , 2008, Stem cells.

[43]  C. Choong,et al.  PDGF, TGF-beta, and FGF signaling is important for differentiation and growth of mesenchymal stem cells (MSCs): transcriptional profiling can identify markers and signaling pathways important in differentiation of MSCs into adipogenic, chondrogenic, and osteogenic lineages. , 2008, Blood.

[44]  G. Dini,et al.  Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study , 2008, The Lancet.

[45]  M. Yarmush,et al.  Mesenchymal stem cell–derived molecules directly modulate hepatocellular death and regeneration in vitro and in vivo , 2008, Hepatology.

[46]  H. Rammensee,et al.  Levo- but not dextro-1-methyl tryptophan abrogates the IDO activity of human dendritic cells. , 2008, Blood.

[47]  R. Zhao,et al.  Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. , 2008, Cell Stem Cell.

[48]  E. Jones,et al.  Human bone marrow mesenchymal stem cells in vivo. , 2007, Rheumatology.

[49]  D. Prockop,et al.  Concise Review: Mesenchymal Stem/Multipotent Stromal Cells: The State of Transdifferentiation and Modes of Tissue Repair—Current Views , 2007, Stem cells.

[50]  L. Kanz,et al.  Novel Markers for the Prospective Isolation of Human MSC , 2007, Annals of the New York Academy of Sciences.

[51]  E. Horwitz,et al.  Human bone marrow mesenchymal stromal cells express the neural ganglioside GD2: a novel surface marker for the identification of MSCs. , 2007, Blood.

[52]  Lothar Just,et al.  Human placenta and bone marrow derived MSC cultured in serum-free, b-FGF-containing medium express cell surface frizzled-9 and SSEA-4 and give rise to multilineage differentiation. , 2007, Differentiation; research in biological diversity.

[53]  R. Czajka,et al.  Morphological and molecular characterization of novel population of CXCR4+ SSEA-4+ Oct-4+ very small embryonic-like cells purified from human cord blood – preliminary report , 2007, Leukemia.

[54]  I. Weissman,et al.  Hematopoietic reconstitution by multipotent adult progenitor cells: precursors to long-term hematopoietic stem cells , 2007, The Journal of experimental medicine.

[55]  K. Lillemoe,et al.  Gender differences in injury induced mesenchymal stem cell apoptosis and VEGF, TNF, IL-6 expression: role of the 55 kDa TNF receptor (TNFR1). , 2007, Journal of molecular and cellular cardiology.

[56]  Catherine M. Verfaillie,et al.  Pluripotency of mesenchymal stem cells derived from adult marrow , 2007, Nature.

[57]  K. Meldrum,et al.  SEX DIMORPHISMS IN ACTIVATED MESENCHYMAL STEM CELL FUNCTION , 2006, Shock.

[58]  A. Caplan,et al.  Mesenchymal stem cells as trophic mediators , 2006, Journal of cellular biochemistry.

[59]  J Ratajczak,et al.  A population of very small embryonic-like (VSEL) CXCR4+SSEA-1+Oct-4+ stem cells identified in adult bone marrow , 2006, Leukemia.

[60]  Mamoru Ito,et al.  Reconstitution of the functional human hematopoietic microenvironment derived from human mesenchymal stem cells in the murine bone marrow compartment. , 2006, Blood.

[61]  D. Prockop,et al.  Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. , 2006, Cytotherapy.

[62]  Christine Klein,et al.  BMC Medicine , 2006 .

[63]  K. Houkin,et al.  I.v. infusion of brain-derived neurotrophic factor gene-modified human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult rat , 2005, Neuroscience.

[64]  Li Zhang,et al.  Defective osteogenesis of the stromal stem cells predisposes CD18-null mice to osteoporosis. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[65]  R. Cancedda,et al.  Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway , 2005, European journal of immunology.

[66]  室井 一男.  What's going on 造血器腫瘍 1)Human mesenchymal stem cells modulate allogeneic immune cell responses. Aggarwal S, Pittenger MF. Blood. 2005;105:1815-22. PMID:15494428. 2)Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Le Blanc K, Rasmusson I, Sun , 2005 .

[67]  K. Houkin,et al.  Mesenchymal stem cells that produce neurotrophic factors reduce ischemic damage in the rat middle cerebral artery occlusion model. , 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

[68]  G. Moonen,et al.  Nestin-positive mesenchymal stem cells favour the astroglial lineage in neural progenitors and stem cells by releasing active BMP4 , 2004, BMC Neuroscience.

[69]  P. Schiller,et al.  Marrow-isolated adult multilineage inducible (MIAMI) cells, a unique population of postnatal young and old human cells with extensive expansion and differentiation potential , 2004, Journal of Cell Science.

[70]  R. Tuan,et al.  Transdifferentiation potential of human mesenchymal stem cells derived from bone marrow , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[71]  Moustapha Hassan,et al.  Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells , 2004, The Lancet.

[72]  Catherine M. Verfaillie,et al.  Pluripotency of mesenchymal stem cells derived from adult marrow , 2002, Nature.

[73]  D. Soligo,et al.  Isolation of bone marrow mesenchymal stem cells by anti-nerve growth factor receptor antibodies. , 2002, Experimental hematology.

[74]  J. Thomson,et al.  Preimplantation Human Embryos and Embryonic Stem Cells Show Comparable Expression of Stage‐Specific Embryonic Antigens , 2002, Stem cells.

[75]  L. Muul,et al.  Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[76]  R Cancedda,et al.  Clonal mesenchymal progenitors from human bone marrow differentiate in vitro according to a hierarchical model. , 2000, Journal of cell science.

[77]  D J Prockop,et al.  Donor variation in the growth properties and osteogenic potential of human marrow stromal cells , 1999, Journal of cellular biochemistry.

[78]  F. Meyskens,et al.  Method for measurement of self-renewal capacity of clonogenic cells from biopsies of metastatic human malignant melanoma. , 1982, Cancer research.

[79]  W. Mackillop,et al.  Measurement of self-renewal in culture of clonogenic cells from human ovarian carcinoma. , 1981, British Journal of Cancer.

[80]  A. Friedenstein,et al.  STROMAL CELLS RESPONSIBLE FOR TRANSFERRING THE MICROENVIRONMENT OF THE HEMOPOIETIC TISSUES: Cloning In Vitro and Retransplantation In Vivo , 1974, Transplantation.

[81]  A. Friedenstein,et al.  Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues. , 1968, Transplantation.