Fuzzy Modeling of Optimal Initial Drug Prescription

This paper focused on a fuzzy approach in migraineurs drug prescription. There is no denying that medicine data records are mixed with uncertainty and probability so all methods concerning migraine drug prescription should be considered in fuzzy environment and designed according to the knowledge of an expert specialist. Overall it seems logical to propose fuzzy approach which could cover all uncertainties. According to fuzzy rule base concepts which are obtained by co-operation of an expert, fuzzy control has been used to model drug prescription system. Finally clinical experiences are used to confirm efficacy of drug prescription model. It should be considered that in most cases this disease may cause health social problems as well as financial obstacle for the companies and in upper stage for governments as a result of reduce work time among the employees. So prescribing optimal initial drug to make the disease stable is obligatory. With the corporation of experts 25 rule bases are introduced and tested on 50 different patient records, result shows that the accuracy of model is 94 % \(\pm \) 5.5 with r-square equal to 0.9148.

[1]  R. Ohrbach,et al.  The International Classification of Headache Disorders, 3rd edition (beta version) , 2013, Cephalalgia : an international journal of headache.

[2]  R. Feldman,et al.  AMERICAN ACADEMY OF NEUROLOGY , 1949 .

[3]  M. Danhof,et al.  Analysis of the Relationship Between Age and Treatment Response in Migraine , 2009, Cephalalgia : an international journal of headache.

[4]  R. Evans Migraine: a question and answer review. , 2009, The Medical clinics of North America.

[5]  Svetlana Simic,et al.  Rule-Based Fuzzy Logic System for Diagnosing Migraine , 2008, SETN.

[6]  Christine Laine,et al.  In the Clinic , 2007, Annals of Internal Medicine.

[7]  Macgregor Ea In the clinic. Migraine. , 2013 .

[8]  Analysis of responses in migraine modelling using hidden Markov models , 2007, Statistics in medicine.

[9]  M. T. Steiner,et al.  Diagnosis of Headache using Artificial Neural Networks , 2010 .

[10]  M. Rezaei,et al.  A Comparative Study of the Effects of Low-Dose Topiramate Versus Sodium Valproate in Migraine Prophylaxis , 2012, The International journal of neuroscience.

[11]  S. Silberstein,et al.  Evidence-based guideline update: Pharmacologic treatment for episodic migraine prevention in adults , 2012, Neurology.

[12]  R. Lipton,et al.  The Acute Treatment of Episodic and Chronic Migraine in the USA , 2009, Cephalalgia : an international journal of headache.

[13]  M. Danhof,et al.  Prediction of Headache Response in Migraine Treatment , 2006, Cephalalgia : an international journal of headache.

[14]  J. Olesen The International Classification of Headache Disorders , 2008, Headache.

[15]  Wolfgang Fichtner Design of VLSI Systems , 1986, Embedded Systems.