Differential diagnosis of neonatal and infantile erythroderma.

Neonatal and infantile erythroderma is a diagnostic and therapeutic challenge. Numerous underlying causes have been reported. Etiologic diagnosis of erythroderma is frequently difficult to establish, and is usually delayed, due to the poor specificity of clinical and histopathologic signs. Differential diagnosis of erythroderma is a multi-step procedure that involves clinical assessment, knowledge of any relevant family history and certain laboratory investigations. Immunodeficiency must be inspected in cases of severe erythroderma with alopecia, failure to thrive, infectious complications, or evocative histologic findings. The prognosis is poor with a high mortality rate in immunodeficiency disorders and severe chronic diseases such as Netherton's syndrome.

[1]  H. Merk,et al.  Neonatal and infantile erythrodermas , 2008, Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG.

[2]  S. Breathnach.  Erythema Multiforme, Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis , 2008 .

[3]  A. Lucky.  Transient Benign Cutaneous Lesions in the Newborn , 2008 .

[4]  V. Sehgal,et al.  Erythroderma/generalized exfoliative dermatitis in pediatric practice: An overview , 2006, International journal of dermatology.

[5]  R. Callard,et al.  LEKTI demonstrable by immunohistochemistry of the skin: a potential diagnostic skin test for Netherton syndrome , 2004, The British journal of dermatology.

[6]  R. Happle,et al.  Cutaneous manifestations of methylmalonic acidemia , 1990, Archives of Dermatological Research.

[7]  L. Eichenfield,et al.  Textbook of Neonatal Dermatology , 2000 .

[8]  Sunil Kumar,et al.  Acrodermatitis Enteropathica , 1997, Clinics in dermatology.

[9]  C. Bodemer,et al.  Neonatal and Infantile Erythrodermas , 2000 .

[10]  P. Hoeger,et al.  Neonatal erythroderma: differential diagnosis and management of the “red baby” , 1998, Archives of disease in childhood.

[11]  B. Lake,et al.  Inherited ichthyoses: a review of the histology of the skin. , 1996, Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association.

[12]  L. Scerri,et al.  Acute Graft‐versus‐Host Disease with Unusual Cutaneous Intracellular Vacuolation in an Infant with Severe Combined Immunodeficiency , 1995, Pediatric dermatology.

[13]  R. Hansen,et al.  Congenital Cutaneous Candidiasis: Case Report and Review , 1995, Pediatric dermatology.

[14]  E. Siegfried,et al.  Cutaneous Congenital Candidiasis: A Case Report , 1995, Pediatric dermatology.

[15]  M. Salleras,et al.  Congenital Erythrodermic Psoriasis: Case Report and Literature Review , 1995, Pediatric dermatology.

[16]  Rasmussen Je.  Erythema multiforme, Stevens-Johnson Syndrome, and toxic epidermal necrolysis. , 1995 .

[17]  J. Harper,et al.  A clinical and immunological study of Netherton's syndrome , 1994, The British journal of dermatology.

[18]  C. Bodemer,et al.  Cutaneous manifestations of methylmalonic and propionic acidaemia: a description based on 38 cases , 1994, The British journal of dermatology.

[19]  R. Hague,et al.  Early diagnosis of severe combined immunodeficiency syndrome. , 1994, Archives of disease in childhood.

[20]  J. Bernard,et al.  In utero acute graft-versus-host disease in a neonate with severe combined immunodeficiency. , 1993, Journal of the American Academy of Dermatology.

[21]  H. Northrup,et al.  Exfoliative erythroderma resulting from inadequate intake of branched-chain amino acids in infants with maple syrup urine disease. , 1993, Archives of dermatology.

[22]  D. Wechsler,et al.  Dermatitis as a presenting sign of cystic fibrosis. , 1992, Archives of dermatology.

[23]  Loughead Jl.  Congenital staphylococcal scaled skin syndrome: report of a case. , 1992 .

[24]  E. Brooks,et al.  Omenn's syndrome and related combined immunodeficiency syndromes: diagnostic considerations in infants with persistent erythroderma and failure to thrive. , 1991, Journal of the American Academy of Dermatology.

[25]  A. Oranje,et al.  Diffuse Cutaneous Mastocytosis Mimicking Staphylococcal Scalded‐Skin Syndrome: Report of Three Cases , 1991, Pediatric dermatology.

[26]  A. Eng,et al.  Congenital Ichthyosiform Erythroderma and Epidermal Nevus , 1991, International journal of dermatology.

[27]  B. Wolf,et al.  Biotinidase Deficiency a , 1985, Advances in pediatrics.

[28]  F. Accurso,et al.  Hypoalbuminemia in young infants with cystic fibrosis. , 1990, The Journal of pediatrics.

[29]  R. Caputo,et al.  Epidermolytic hyperkeratosis: generalized form in children from parents with systematized linear form , 1990, The British journal of dermatology.

[30]  S. Menni,et al.  Infantile Seborrheic Dermatitis: Seven‐Year Follow‐up and Some Prognostic Criteria , 1989, Pediatric dermatology.

[31]  E. Bonifazi,et al.  Atopic dermatitis in the first six months of life. , 1989, Acta dermato-venereologica. Supplementum.

[32]  J. Bressieux,et al.  [Neonatal erythroderma. Conceptual development over 100 years: from 1889 to 1989]. , 1989, Annales de dermatologie et de venereologie.

[33]  F. Nkrumah,et al.  Congenital syphilis in the newborn. , 1988, Archives of disease in childhood.

[34]  R. Levinsky,et al.  Syndrome of erythroderma, failure to thrive, and diarrhea in infancy: a manifestation of immunodeficiency. , 1988, Pediatrics.

[35]  J. Mickell,et al.  Childhood acquired immune deficiency syndrome manifesting as acrodermatitis enteropathica. , 1986, The Journal of pediatrics.

[36]  S. Muller,et al.  Netherton's syndrome: Report of a case and review of the literature , 1985 .

[37]  P. Elias,et al.  Heterogeneity in autosomal recessive ichthyosis. Clinical and biochemical differentiation of lamellar ichthyosis and nonbullous congenital ichthyosiform erythroderma. , 1985, Archives of dermatology.

[38]  A. Oranje,et al.  Toxic epidermal necrolysis probably due to Klebsiella pneumoniae sepsis. , 1984, Dermatologica.

[39]  M. Williams,et al.  Alopecia and periorificial dermatitis in biotin-responsive multiple carboxylase deficiency. , 1983, Journal of the American Academy of Dermatology.

[40]  R. Hansen,et al.  Cystic fibrosis manifesting with acrodermatitis enteropathica-like eruption. Association with essential fatty acid and zinc deficiencies. , 1983, Archives of dermatology.

[41]  L. Teodori,et al.  Report of a Case and Review of the Literature , 1981 .

[42]  S. Shuster,et al.  Diffuse cutaneous mastocytosis: a report of neonatal onset. , 1979, Acta dermato-venereologica.

[43]  E. Farber,et al.  Infantile psoriasis. , 1977, American journal of diseases of children.

[44]  H. Zachariae,et al.  Pustular psoriasis and arthritis in congenital psoriasiform erythroderma. , 1972, Dermatologica.