Quantitative and Qualitative Evaluation of Convolutional Neural Networks with a Deeper U-Net for Sparse-View Computed Tomography Reconstruction.

RATIONALE AND OBJECTIVES To evaluate the utility of a convolutional neural network (CNN) with an increased number of contracting and expanding paths of U-net for sparse-view CT reconstruction. MATERIALS AND METHODS This study used 60 anonymized chest CT cases from a public database called "The Cancer Imaging Archive". Eight thousand images from 40 cases were used for training. Eight hundred and 80 images from another 20 cases were used for quantitative and qualitative evaluation, respectively. Sparse-view CT images subsampled by a factor of 20 were simulated, and two CNNs were trained to create denoised images from the sparse-view CT. A CNN based on U-net with residual learning with four contracting and expanding paths (the preceding CNN) was compared with another CNN with eight contracting and expanding paths (the proposed CNN) both quantitatively (peak signal to noise ratio, structural similarity index), and qualitatively (the scores given by two radiologists for anatomical visibility, artifact and noise, and overall image quality) using the Wilcoxon signed-rank test. Nodule and emphysema appearance were also evaluated qualitatively. RESULTS The proposed CNN was significantly better than the preceding CNN both quantitatively and qualitatively (overall image quality interquartile range, 3.0-3.5 versus 1.0-1.0 reported from the preceding CNN; p < 0.001). However, only 2 of 22 cases used for emphysematous evaluation (2 CNNs for every 11 cases with emphysema) had an average score of ≥ 2 (on a 3 point scale). CONCLUSION Increasing contracting and expanding paths may be useful for sparse-view CT reconstruction with CNN. However, poor reproducibility of emphysema appearance should also be noted.