Therapeutic strategies for treating hair loss

[1]  K. Stenn,et al.  Bioengineering the Hair Follicle , 2007, Organogenesis.

[2]  M. Akiyama,et al.  Hair follicle stem cell-targeted gene transfer and reconstitution system , 2006, Gene Therapy.

[3]  R. Paus,et al.  Human scalp hair follicles are both a target and a source of prolactin, which serves as an autocrine and/or paracrine promoter of apoptosis-driven hair follicle regression. , 2006, The American journal of pathology.

[4]  D. Shander,et al.  Apoptosis in the hair follicle. , 2006, The Journal of investigative dermatology.

[5]  E. Fuchs,et al.  The hair cycle , 2006, Journal of Cell Science.

[6]  R. Hartmann,et al.  Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids. , 2006, Journal of medicinal chemistry.

[7]  G. Cotsarelis.  Gene expression profiling gets to the root of human hair follicle stem cells. , 2005, The Journal of clinical investigation.

[8]  Mark C Udey,et al.  Characterization and isolation of stem cell-enriched human hair follicle bulge cells. , 2005, The Journal of clinical investigation.

[9]  A. Bosio,et al.  Substantial sex-dependent differences in the response of human scalp hair follicles to estrogen stimulation in vitro advocate gender-tailored management of female versus male pattern balding. , 2005, The journal of investigative dermatology. Symposium proceedings.

[10]  J. Lademann,et al.  Follicular targeting--a promising tool in selective dermatotherapy. , 2005, The journal of investigative dermatology. Symposium proceedings.

[11]  S. Inui,et al.  Role of androgen in mesenchymal epithelial interactions in human hair follicle. , 2005, The journal of investigative dermatology. Symposium proceedings.

[12]  C. Lawrence,et al.  Plasticity of rodent and human hair follicle dermal cells: implications for cell therapy and tissue engineering. , 2005, The journal of investigative dermatology. Symposium proceedings.

[13]  R. Paus,et al.  Zinc as an ambivalent but potent modulator of murine hair growth in vivo– preliminary observations , 2005, Experimental dermatology.

[14]  N. Hunt,et al.  The psychological impact of alopecia , 2005, BMJ : British Medical Journal.

[15]  K. Kaufman,et al.  Effects of Finasteride (1 mg) on Hair Transplant , 2005, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[16]  E. Healy,et al.  α-Melanocyte-Stimulating Hormone Suppresses Antigen-Induced Lymphocyte Proliferation in Humans Independently of Melanocortin 1 Receptor Gene Status1 , 2005, The Journal of Immunology.

[17]  G. Cotsarelis,et al.  Bioengineering the hair follicle: fringe benefits of stem cell technology. , 2005, Current opinion in biotechnology.

[18]  E. Fuchs,et al.  Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle , 2005, PLoS biology.

[19]  L. Rudnicka,et al.  Effective treatment of female androgenic alopecia with dutasteride. , 2005, Journal of drugs in dermatology : JDD.

[20]  K. Nakajima,et al.  Structural optimization of pep7, a small peptide extracted from epimorphin, for effective induction of hair follicle anagen , 2005, Experimental dermatology.

[21]  D. Tobin,et al.  Premature termination of hair follicle morphogenesis and accelerated hair follicle cycling in Iasi congenital atrichia (fzica) mice points to fuzzy as a key element of hair cycle control , 2005, Experimental dermatology.

[22]  R. Paus,et al.  Human hair follicles display a functional equivalent of the hypothalamic‐pituitary‐adrenal (HPA) axis and synthesize cortisol , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[23]  R. Paus,et al.  A role of melatonin in neuroectodermal‐mesodermal interactions: the hair follicle synthesizes melatonin and expresses functional melatonin receptors , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[24]  R. Paus,et al.  A guide to assessing damage response pathways of the hair follicle: lessons from cyclophosphamide-induced alopecia in mice. , 2005, The Journal of investigative dermatology.

[25]  E. Ream,et al.  Hair loss with chemotherapy: at a loss over its management? , 2005, European journal of cancer care.

[26]  R. Paus,et al.  Towards dissecting the pathogenesis of retinoid-induced hair loss: all-trans retinoic acid induces premature hair follicle regression (catagen) by upregulation of transforming growth factor-beta2 in the dermal papilla. , 2005, The Journal of investigative dermatology.

[27]  M. Thornton.  Oestrogen functions in skin and skin appendages , 2005, Expert opinion on therapeutic targets.

[28]  P. Kelley,et al.  The effects of tea polyphenolic compounds on hair loss among rodents. , 2005, Journal of the National Medical Association.

[29]  C. D. Kim,et al.  The hair growth promoting effect of Asiasari radix extract and its molecular regulation. , 2005, Journal of dermatological science.

[30]  W. S. Millar,et al.  Netherton Syndrome with Extensive Skin Peeling and Failure to Thrive due to a Homozygous Frameshift Mutation in SPINK5 , 2005, Dermatology.

[31]  S. Kondo,et al.  Influence of prostaglandin F2α and its analogues on hair regrowth and follicular melanogenesis in a murine model , 2005, Experimental dermatology.

[32]  M. Yoshikawa,et al.  Anti-alopecia mechanisms of soymetide-4, an immunostimulating peptide derived from soy β-conglycinin , 2005, Peptides.

[33]  J. Shapiro,et al.  Management of hair loss. , 2005, Dermatologic clinics.

[34]  Yi‐Ju Chen,et al.  Novel and established potassium channel openers stimulate hair growth in vitro: implications for their modes of action in hair follicles. , 2005, The Journal of investigative dermatology.

[35]  Fallberichte , 2005 .

[36]  E. Bratoeff,et al.  Recent advances in the chemistry and pharmacological activity of new steroidal antiandrogens and 5 alpha-reductase inhibitors. , 2005, Current medicinal chemistry.

[37]  S. Hunt,et al.  Mast cell deficient and neurokinin-1 receptor knockout mice are protected from stress-induced hair growth inhibition , 2005, Journal of Molecular Medicine.

[38]  R. Sinclair,et al.  Treatment of female pattern hair loss with oral antiandrogens , 2005, The British journal of dermatology.

[39]  J. Gustafsson,et al.  Hair Cycle Control by Estrogens: Catagen Induction via Estrogen Receptor (ER)-α Is Checked by ERβ Signaling , 2005 .

[40]  W. Breed,et al.  Prevention of chemotherapy-induced hair loss by scalp cooling. , 2005, Annals of oncology : official journal of the European Society for Medical Oncology.

[41]  J. Shapiro,et al.  Evaluation and treatment of male and female pattern hair loss. , 2005, Journal of the American Academy of Dermatology.

[42]  M. Yoshikawa,et al.  Anti-Alopecia Effect of Gly-Leu-Phe, an Immunostimulating Peptide Derived from α-Lactalbumin , 2005 .

[43]  Jack Green,et al.  A gene for pili annulati maps to the telomeric region of chromosome 12q. , 2004, The Journal of investigative dermatology.

[44]  R. Paus,et al.  In search of the "hair cycle clock": a guided tour. , 2004, Differentiation; research in biological diversity.

[45]  Padhraic Smyth,et al.  Identification of hair cycle-associated genes from time-course gene expression profile data by using replicate variance , 2004, Proc. Natl. Acad. Sci. USA.

[46]  A. Tosti,et al.  Hypertrichosis of the eyelashes caused by bimatoprost. , 2004, Journal of the American Academy of Dermatology.

[47]  R. Trüeb.  Finasteride Treatment of Patterned Hair Loss in Normoandrogenic Postmenopausal Women , 2004, Dermatology.

[48]  B. Gilchrest,et al.  Fas Signaling Is Involved in the Control of Hair Follicle Response to Chemotherapy , 2004, Cancer Research.

[49]  P. Arck,et al.  Burden of hair loss: stress and the underestimated psychosocial impact of telogen effluvium and androgenetic alopecia. , 2004, The Journal of investigative dermatology.

[50]  G. Açıkgöz,et al.  An Open, Randomized, Comparative Study of Oral Finasteride and 5% Topical Minoxidil in Male Androgenetic Alopecia , 2004, Dermatology.

[51]  B. Klapp,et al.  Neurogenic inflammation in stress-induced termination of murine hair growth is promoted by nerve growth factor. , 2004, The American journal of pathology.

[52]  M. Kawashima,et al.  Finasteride in the treatment of Japanese men with male pattern hair loss. , 2004, European journal of dermatology : EJD.

[53]  M. Rapaport.  Follow‐Up of 1 mg Finasteride Treatment of Male Pattern Baldness—Difference between Clinical Trials and Private Office Follow‐Up: Influences on Prescribing Habits Evaluated , 2004, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[54]  D. Piacquadio,et al.  A randomized, placebo-controlled trial of 5% and 2% topical minoxidil solutions in the treatment of female pattern hair loss. , 2004, Journal of the American Academy of Dermatology.

[55]  W. Bergfeld,et al.  Finasteride in the treatment of alopecia , 2004, Expert opinion on pharmacotherapy.

[56]  Yaping Liu,et al.  Capturing and profiling adult hair follicle stem cells , 2004, Nature Biotechnology.

[57]  R. Paus,et al.  Estrogens and human scalp hair growth-still more questions than answers. , 2004, The Journal of investigative dermatology.

[58]  P. Elsner,et al.  EEMCO Guidance for the Assessment of Hair Shedding and Alopecia , 2004, Skin Pharmacology and Physiology.

[59]  R. Paus,et al.  Collapse and restoration of MHC class-I-dependent immune privilege: exploiting the human hair follicle as a model. , 2004, The American journal of pathology.

[60]  K. Taylor,et al.  Androgen excess in women: experience with over 1000 consecutive patients. , 2004, The Journal of clinical endocrinology and metabolism.

[61]  H. Kleinman,et al.  Thymosin β4 promotes angiogenesis, wound healing, and hair follicle development , 2004, Mechanisms of Ageing and Development.

[62]  I. Bandaranayake,et al.  Hair loss remedies--separating fact from fiction. , 2004, Cutis.

[63]  D. Givol,et al.  Hair growth induction by the tellurium immunomodulator AS101: association with delayed terminal differentiation of follicular keratinocytes and ras‐dependent up‐regulation of KGF expression , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[64]  D. Philp,et al.  Thymosin β4 increases hair growth by activation of hair follicle stem cells , 2004 .

[65]  J. Rundegren,et al.  Minoxidil: mechanisms of action on hair growth , 2004, The British journal of dermatology.

[66]  P. Elsner,et al.  Melatonin increases anagen hair rate in women with androgenetic alopecia or diffuse alopecia: results of a pilot randomized controlled trial , 2004, The British journal of dermatology.

[67]  E. Fuchs,et al.  Defining the Epithelial Stem Cell Niche in Skin , 2004, Science.

[68]  A. Christiano,et al.  De novo mutations in monilethrix , 2003, Experimental dermatology.

[69]  B. Klapp,et al.  Topical minoxidil counteracts stress‐induced hair growth inhibition in mice , 2003, Experimental dermatology.

[70]  A.G. Messenger,et al.  Guidelines Guidelines for the management of alopecia areata , 2003 .

[71]  K. Lammers,et al.  The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial , 2003, The British journal of dermatology.

[72]  D. Tobin,et al.  Plasticity and cytokinetic dynamics of the hair follicle mesenchyme: implications for hair growth control. , 2003, The Journal of investigative dermatology.

[73]  V. Botchkarev.  Molecular mechanisms of chemotherapy-induced hair loss. , 2003, The journal of investigative dermatology. Symposium proceedings.

[74]  B. Klapp,et al.  Stress inhibits hair growth in mice by induction of premature catagen development and deleterious perifollicular inflammatory events via neuropeptide substance P-dependent pathways. , 2003, The American journal of pathology.

[75]  C. Chuong,et al.  `Cyclic alopecia' in Msx2 mutants: defects in hair cycling and hair shaft differentiation , 2003, Development.

[76]  J. M. Lipton,et al.  &agr;-Melanocyte-stimulating hormone protects the allograft in experimental heart transplantation1 , 2002 .

[77]  Ayako Kamimura,et al.  Procyanidin B‐3, isolated from barley and identified as a hair‐growth stimulant, has the potential to counteract inhibitory regulation by TGF‐β1 , 2002, Experimental dermatology.

[78]  A. Kamimura,et al.  Procyanidin B‐2, extracted from apples, promotes hair growth: a laboratory study , 2002, The British journal of dermatology.

[79]  R. Paus,et al.  Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: annotated tables , 2001, Experimental dermatology.

[80]  D. Whiting.  Possible mechanisms of miniaturization during androgenetic alopecia or pattern hair loss. , 2001, Journal of the American Academy of Dermatology.

[81]  M. Holick,et al.  A new strategy for modulating chemotherapy-induced alopecia, using PTH/PTHrP receptor agonist and antagonist. , 2001, The Journal of investigative dermatology.

[82]  A. Kamimura,et al.  The first clinical trial of topical application of procyanidin B‐2 to investigate its potential as a hair growing agent , 2001, Phytotherapy research : PTR.

[83]  A. Christiano,et al.  Trans-gender induction of hair follicles , 1999, Nature.

[84]  V H Price,et al.  Treatment of hair loss. , 1999, The New England journal of medicine.

[85]  R Paus,et al.  The biology of hair follicles. , 1999, The New England journal of medicine.

[86]  J. Shapiro,et al.  Finasteride in the treatment of men with androgenetic alopecia. Finasteride Male Pattern Hair Loss Study Group. , 1998, Journal of the American Academy of Dermatology.

[87]  R. Paus,et al.  Cutaneous Immunomodulation and Coordination of Skin Stress Responses by α‐Melanocyte‐Stimulating Hormone a , 1998 .

[88]  Carina,et al.  Analysis of apoptosis during hair follicle regression (catagen) , 1997, The American journal of pathology.

[89]  M. Holick,et al.  Control of hair growth with parathyroid hormone (7-34). , 1997, The Journal of investigative dermatology.

[90]  R. Paus,et al.  Hair growth modulation by topical immunophilin ligands: induction of anagen, inhibition of massive catagen development, and relative protection from chemotherapy-induced alopecia. , 1997, The American journal of pathology.

[91]  R. Smart,et al.  An estrogen receptor pathway regulates the telogen-anagen hair follicle transition and influences epidermal cell proliferation. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[92]  R. Paus,et al.  Topical calcitriol enhances normal hair regrowth but does not prevent chemotherapy-induced alopecia in mice. , 1996, Cancer research.

[93]  T. Kealey,et al.  WHOLE HAIR FOLLICLE CULTURE , 1996 .

[94]  D. Coffin,et al.  Protection from radiation-induced alopecia with topical application of nitroxides: fractionated studies. , 1996, The cancer journal from Scientific American.

[95]  R. Paus,et al.  Hair growth control by immunosuppression , 1996, Archives of Dermatological Research.

[96]  T. Kealey,et al.  Effects of insulin and insulin-like growth factors on cultured human hair follicles: IGF-I at physiologic concentrations is an important regulator of hair follicle growth in vitro. , 1994, The Journal of investigative dermatology.

[97]  S. Eichmüller,et al.  Chemotherapy-induced alopecia in mice. Induction by cyclophosphamide, inhibition by cyclosporine A, and modulation by dexamethasone. , 1994, The American journal of pathology.

[98]  J. Mazurkiewicz,et al.  Detection of proopiomelanocortin-derived antigens in normal and pathologic human skin. , 1993, The Journal of laboratory and clinical medicine.

[99]  F. Malkinson,et al.  Prostaglandins protect against murine hair injury produced by ionizing radiation or doxorubicin. , 1993, The Journal of investigative dermatology.

[100]  R. Dawber,et al.  Diseases of the Hair and Scalp , 1991 .

[101]  M. Green,et al.  Human hair growth in vitro. , 1990, Journal of cell science.

[102]  R. Paus,et al.  Telogen skin contains an inhibitor of hair growth , 1990, The British journal of dermatology.

[103]  R. Ead,et al.  Oral zinc sulphate in alopacia areata–a double blind trial , 1981, The British journal of dermatology.

[104]  A. Gilhar,et al.  Alopecia areata: a tissue specific autoimmune disease of the hair follicle. , 2006, Autoimmunity reviews.

[105]  B. Klapp,et al.  p75 Neurotrophin Receptor-Mediated Signaling Promotes Human Hair Follicle Regression (Catagen). , 2006, The American journal of pathology.

[106]  R. Paus,et al.  A 'hairy' privilege. , 2005, Trends in immunology.

[107]  R. Hoffman.  Gene and stem cell therapy of the hair follicle. , 2005, Methods in molecular biology.

[108]  M. Schaller,et al.  RU 58841-myristate--prodrug development for topical treatment of acne and androgenetic alopecia. , 2005, Die Pharmazie.

[109]  R. Paus,et al.  Topical estrogen accelerates hair regrowth in mice after chemotherapy-induced alopecia by favoring the dystrophic catagen response pathway to damage. , 2004, The Journal of investigative dermatology.

[110]  P. Leghissa,et al.  Female androgenetic alopecia treated by finasteride: a case forward. , 2004, Acta dermato-venereologica.

[111]  M. Namazi.  Prostaglandin analogs for hair growth: greater expectations. , 2003, Dermatology online journal.

[112]  R Paus,et al.  Controls of hair follicle cycling. , 2001, Physiological reviews.

[113]  R. Paus,et al.  Glucocorticoid effect on hair growth initiation: a reconsideration. , 1993, Skin pharmacology : the official journal of the Skin Pharmacology Society.

[114]  H. Lozeron,et al.  A Propos of Chemical Radioprotection , 1965 .