Noninvasive assessment of airway inflammation in asthma

[1]  P. Shah,et al.  Increased nitrotyrosine in exhaled breath condensate in cystic fibrosis. , 2001, The European respiratory journal.

[2]  P. Barnes,et al.  Exhaled markers of pulmonary disease. , 2001, American journal of respiratory and critical care medicine.

[3]  E. Israel,et al.  Safety and reproducibility of sputum induction in asthmatic subjects in a multicenter study. , 2001, American journal of respiratory and critical care medicine.

[4]  P. Gibson,et al.  Heterogeneity of airway inflammation in persistent asthma : evidence of neutrophilic inflammation and increased sputum interleukin-8. , 2001, Chest.

[5]  P. Casán,et al.  Mild exacerbations and eosinophilic inflammation in patients with stable, well-controlled asthma after 1 year of follow-up. , 2001, Chest.

[6]  P. Sterk,et al.  Benefits of high altitude allergen avoidance in atopic adolescents with moderate to severe asthma, over and above treatment with high dose inhaled steroids , 2001, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[7]  C. Jenkins,et al.  Predictive markers of asthma exacerbation during stepwise dose reduction of inhaled corticosteroids. , 2001, American journal of respiratory and critical care medicine.

[8]  M. Anvari,et al.  Lipid-laden macrophages in induced sputum are a marker of oropharyngeal reflux and possible gastric aspiration. , 2000, The European respiratory journal.

[9]  P. Gibson,et al.  Noninvasive assessment of airway inflammation in children: induced sputum, exhaled nitric oxide, and breath condensate. , 2000, The European respiratory journal.

[10]  R. Leigh,et al.  Success and safety of sputum induction in the clinical setting. , 2000, The European respiratory journal.

[11]  P. Barnes,et al.  Elevation of exhaled ethane concentration in asthma. , 2000, American journal of respiratory and critical care medicine.

[12]  P. Barnes,et al.  Clinical aspects of exhaled nitric oxide. , 2000, The European respiratory journal.

[13]  J. Priest,et al.  Exhaled nitric oxide levels correlate with measures of disease control in asthma. , 2000, The Journal of allergy and clinical immunology.

[14]  F. Hargreave,et al.  A comparison of exhaled nitric oxide and induced sputum as markers of airway inflammation. , 2000, The Journal of allergy and clinical immunology.

[15]  P. Barnes,et al.  Increased nitrotyrosine in exhaled breath condensate of patients with asthma. , 2000, American journal of respiratory and critical care medicine.

[16]  A. Spanevello,et al.  Induced sputum cellularity. Reference values and distribution in normal volunteers. , 2000, American journal of respiratory and critical care medicine.

[17]  M. Silverman,et al.  Induced sputum in children: feasibility, repeatability, and relation of findings to asthma severity. , 2000, Thorax.

[18]  H. Magnussen,et al.  Update on sputum methodology. , 2000, The European respiratory journal.

[19]  F. Hargreave,et al.  Induced sputum examination: diagnosis of pulmonary involvement in Fabry's disease , 2000, Thorax.

[20]  T. Sandström,et al.  Airway inflammation following exposure to diesel exhaust: a study of time kinetics using induced sputum. , 2000, The European respiratory journal.

[21]  R. Hancox,et al.  Effects of terbutaline and budesonide on sputum cells and bronchial hyperresponsiveness in asthma. , 2000, American journal of respiratory and critical care medicine.

[22]  I. Pavord,et al.  Sputum cysteinyl leukotrienes increase 24 hours after allergen inhalation in atopic asthmatics. , 2000, American journal of respiratory and critical care medicine.

[23]  J Bousquet,et al.  Asthma. From bronchoconstriction to airways inflammation and remodeling. , 2000, American journal of respiratory and critical care medicine.

[24]  J. Bousquet,et al.  15-Lipoxygenase expression and 15(S)-hydroxyeicoisatetraenoic acid release and reincorporation in induced sputum of asthmatic subjects. , 2000, The Journal of allergy and clinical immunology.

[25]  P. Gibson,et al.  Airway mast cells and eosinophils correlate with clinical severity and airway hyperresponsiveness in corticosteroid-treated asthma. , 2000, The Journal of allergy and clinical immunology.

[26]  R. Pauwels,et al.  A long-term study of the antiinflammatory effect of low-dose budesonide plus formoterol versus high-dose budesonide in asthma. , 2000, American journal of respiratory and critical care medicine.

[27]  P. Howarth,et al.  Effects of short-term exposure to 0.2 ppm ozone on biomarkers of inflammation in sputum, exhaled nitric oxide, and lung function in subjects with mild atopic asthma. , 2000, Journal of occupational and environmental medicine.

[28]  P. Gibson,et al.  Interleukin-8 secretion and neutrophil recruitment accompanies induced sputum eosinophil activation in children with acute asthma. , 2000, American journal of respiratory and critical care medicine.

[29]  K. Chung,et al.  Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in mild to moderately severe asthma , 2000, Thorax.

[30]  K. J. Macleod,et al.  Non-invasive markers of airway inflammation as predictors of oral steroid responsiveness in asthma , 2000, Thorax.

[31]  G. Scano,et al.  Association of sputum parameters with clinical and functional measurements in asthma , 2000, Thorax.

[32]  N. Hara,et al.  Once–Daily Theophylline Reduces Serum Eosinophil Cationic Protein and Eosinophil Levels in Induced Sputum of Asthmatics , 2000, International Archives of Allergy and Immunology.

[33]  P. O'Byrne,et al.  Induced sputum cell counts in healthy adults. , 2000, American journal of respiratory and critical care medicine.

[34]  Brightling,et al.  Eosinophilic bronchitis − what is it and why is it important? , 2000, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[35]  U. Lalloo,et al.  Neutrophils in induced sputum arise from central airways. , 2000, The European respiratory journal.

[36]  J. Fahy,et al.  Low- and high-dose fluticasone propionate in asthma; effects during and after treatment. , 2000, The European respiratory journal.

[37]  P. Barnes,et al.  Changes in sputum eosinophils predict loss of asthma control. , 2000, American journal of respiratory and critical care medicine.

[38]  R. Djukanović,et al.  The relationship between airways inflammation and asthma severity. , 2000, American journal of respiratory and critical care medicine.

[39]  P. Barnes,et al.  Effect of inhaled ozone on exhaled nitric oxide, pulmonary function, and induced sputum in normal and asthmatic subjects , 1999, Thorax.

[40]  P. Barnes,et al.  Exhaled carbon monoxide in childhood asthma. , 1999, The Journal of pediatrics.

[41]  K. Chung,et al.  Neutrophilic inflammation in severe persistent asthma. , 1999, American journal of respiratory and critical care medicine.

[42]  H. Bisgaard,et al.  NO in exhaled air of asthmatic children is reduced by the leukotriene receptor antagonist montelukast. , 1999, American journal of respiratory and critical care medicine.

[43]  F. Hargreave,et al.  Diagnosis of left-ventricular dysfunction from induced sputum examination , 1999, The Lancet.

[44]  H. Magnussen,et al.  Sequentially induced sputum in patients with asthma or chronic obstructive pulmonary disease. , 1999, The European respiratory journal.

[45]  J. Fahy,et al.  Fractional analysis of sequential induced sputum samples during sputum induction: evidence that different lung compartments are sampled at different time points. , 1999, The Journal of allergy and clinical immunology.

[46]  L. Boulet,et al.  Montelukast reduces airway eosinophilic inflammation in asthma: a randomized, controlled trial. , 1999, The European respiratory journal.

[47]  P. Sterk,et al.  Lung function and sputum characteristics of patients with severe asthma during an induced exacerbation by double-blind steroid withdrawal. , 1999, American journal of respiratory and critical care medicine.

[48]  P. Montuschi,et al.  Increased 8-isoprostane, a marker of oxidative stress, in exhaled condensate of asthma patients. , 1999, American journal of respiratory and critical care medicine.

[49]  I. Pavord,et al.  Non-eosinophilic cor ticosteroid unresponsive asthma , 1999, The Lancet.

[50]  A. Boner,et al.  Exhaled nitric oxide and sputum eosinophil markers of inflammation in asthmatic children. , 1999, The European respiratory journal.

[51]  A. Zwinderman,et al.  Effect of inhaled steroids on airway hyperresponsiveness, sputum eosinophils, and exhaled nitric oxide levels in patients with asthma , 1999, Thorax.

[52]  J. Vandenbroucke,et al.  Clinical control and histopathologic outcome of asthma when using airway hyperresponsiveness as an additional guide to long-term treatment. The AMPUL Study Group. , 1999, American journal of respiratory and critical care medicine.

[53]  C. Lemière,et al.  Diagnosing occupational asthma: use of induced sputum. , 1999, The European respiratory journal.

[54]  H. Magnussen,et al.  Ozone-induced airway inflammatory changes differ between individuals and are reproducible. , 1999, American journal of respiratory and critical care medicine.

[55]  C. White,et al.  Comparison of exhaled nitric oxide to spirometry during emergency treatment of asthma exacerbations with glucocorticoids in children. , 1999, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[56]  P. Barnes,et al.  Effect of differing doses of inhaled budesonide on markers of airway inflammation in patients with mild asthma , 1999, Thorax.

[57]  E. Baraldi,et al.  Effect of natural grass pollen exposure on exhaled nitric oxide in asthmatic children. , 1999, American journal of respiratory and critical care medicine.

[58]  K. Chung,et al.  Effect of inhaled budesonide on lung function and airway inflammation. Assessment by various inflammatory markers in mild asthma. , 1999, American journal of respiratory and critical care medicine.

[59]  S. Durham,et al.  Increase in exhaled nitric oxide levels in patients with difficult asthma and correlation with symptoms and disease severity despite treatment with oral and inhaled corticosteroids , 1998, Thorax.

[60]  J. Bousquet,et al.  Sputum metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio correlates with airflow obstruction in asthma and chronic bronchitis. , 1998, American journal of respiratory and critical care medicine.

[61]  K. Chung,et al.  An inhaled steroid improves markers of airway inflammation in patients with mild asthma. , 1998, The European respiratory journal.

[62]  F. Hargreave,et al.  Sputum eosinophilia predicts benefit from prednisone in smokers with chronic obstructive bronchitis. , 1998, American journal of respiratory and critical care medicine.

[63]  S. Kudoh,et al.  Severity of exercise-induced bronchoconstriction is related to airway eosinophilic inflammation in patients with asthma. , 1998, The European respiratory journal.

[64]  I. Horváth,et al.  Combined use of exhaled hydrogen peroxide and nitric oxide in monitoring asthma. , 1998, American journal of respiratory and critical care medicine.

[65]  M. Sears,et al.  Potential masking effects of salmeterol on airway inflammation in asthma. , 1998, American journal of respiratory and critical care medicine.

[66]  Gibson,et al.  Induced sputum eosinophil cationic protein (ECP) measurement in asthma and chronic obstructive airway disease (COAD) , 1998, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[67]  R. Djukanović,et al.  Sputum eosinophilia is more closely associated with airway responsiveness to bradykinin than methacholine in asthma. , 1998, The European respiratory journal.

[68]  M. Fukuoka,et al.  The effect of theophylline on blood and sputum eosinophils and ECP in patients with bronchial asthma. , 1998, International journal of immunopharmacology.

[69]  P. Barnes,et al.  Raised levels of exhaled carbon monoxide are associated with an increased expression of heme oxygenase-1 in airway macrophages in asthma: a new marker of oxidative stress , 1998, Thorax.

[70]  H. Boushey,et al.  Effect of low-dose beclomethasone dipropionate on asthma control and airway inflammation. , 1998, The European respiratory journal.

[71]  P. O'Byrne,et al.  Increases in airway eosinophils and interleukin-5 with minimal bronchoconstriction during repeated low-dose allergen challenge in atopic asthmatics. , 1998, The European respiratory journal.

[72]  J. Bousquet,et al.  Safety of inducing sputum in patients with asthma of varying severity. , 1998, American journal of respiratory and critical care medicine.

[73]  R. Pauwels,et al.  Methods of examining induced sputum: do differences matter? , 1998, The European respiratory journal.

[74]  J. Bousquet,et al.  Increased Levels of Elastase and α1-Antitrypsin in Sputum of Asthmatic Patients , 1998 .

[75]  H. Magnussen,et al.  Changes in sputum composition between two inductions performed on consecutive days. , 1998, Thorax.

[76]  A. Niimi,et al.  Serum eosinophil cationic protein as a marker of eosinophilic inflammation in asthma , 1998, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[77]  S. Dahlén,et al.  Can asthma be studied in the urine? , 1998, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[78]  K. Chung,et al.  Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma. , 1998, Thorax.

[79]  Iguchi,et al.  Clinical utility of serum levels of eosinophil cationic protein (ECP) for monitoring and predicting clinical course in childhood asthma , 1998, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[80]  Pauwels,et al.  Serum eosinophil cationic protein in asthma: what does it mean? , 1998, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[81]  V. Brusasco,et al.  Dissociation between airway inflammation and airway hyperresponsiveness in allergic asthma. , 1998, American journal of respiratory and critical care medicine.

[82]  C. White,et al.  Comparison of exhaled nitric oxide, serum eosinophilic cationic protein, and soluble interleukin‐2 receptor in exacerbations of pediatric asthma , 1997, Pediatric pulmonology.

[83]  H Sasaki,et al.  Increased carbon monoxide in exhaled air of asthmatic patients. , 1997, American journal of respiratory and critical care medicine.

[84]  D. Yates,et al.  Effect of short- and long-acting inhaled beta2-agonists on exhaled nitric oxide in asthmatic patients. , 1997, The European respiratory journal.

[85]  P. Sterk,et al.  Comparison of inflammatory cell counts in asthma: induced sputum vs bronchoalveolar lavage and bronchial biopsies , 1997, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[86]  P. Scheff,et al.  Exhaled pentane and nitric oxide levels in patients with obstructive sleep apnea. , 1997, Chest.

[87]  F. Hargreave,et al.  Sputum in severe exacerbations of asthma: kinetics of inflammatory indices after prednisone treatment. , 1997, American journal of respiratory and critical care medicine.

[88]  P. Barnes,et al.  Cellular profiles in asthmatic airways: a comparison of induced sputum, bronchial washings, and bronchoalveolar lavage fluid. , 1997, Thorax.

[89]  F. Hargreave,et al.  Measuring airway inflammation in asthma: eosinophils and eosinophilic cationic protein in induced sputum compared with peripheral blood. , 1997, The Journal of allergy and clinical immunology.

[90]  D Olivieri,et al.  Airways remodeling is a distinctive feature of asthma and is related to severity of disease. , 1997, Chest.

[91]  Y. Nakamura,et al.  Relationship between activated eosinophils of the bronchial mucosa and serum eosinophil cationic protein in atopic asthma. , 1997, International archives of allergy and immunology.

[92]  S. Kharitonov,et al.  Exhaled and nasal nitric oxide measurements : recommendations , 1997 .

[93]  P. Sterk,et al.  Repeatability of cellular and soluble markers of inflammation in induced sputum from patients with asthma. , 1996, The European respiratory journal.

[94]  M. Jordana,et al.  Effects of inhaled budesonide on allergen-induced airway responses and airway inflammation. , 1996, American journal of respiratory and critical care medicine.

[95]  F. Hargreave,et al.  Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid-phase measurements. , 1996, American journal of respiratory and critical care medicine.

[96]  I. Strannegård,et al.  Urinary eosinophil protein X in children with atopic asthma: a useful marker of antiinflammatory treatment. , 1996, The Journal of allergy and clinical immunology.

[97]  R. de Bruijn,et al.  Effect of allergen avoidance at high altitude on direct and indirect bronchial hyperresponsiveness and markers of inflammation in children with allergic asthma. , 1996, Thorax.

[98]  R. Dahl,et al.  Eosinophil and neutrophil activity in asthma in a one-year trial with inhaled budesonide. The impact of smoking. , 1996, American journal of respiratory and critical care medicine.

[99]  P. Sterk,et al.  Relationship between the inflammatory infiltrate in bronchial biopsy specimens and clinical severity of asthma in patients treated with inhaled steroids. , 1996, Thorax.

[100]  P. Barnes,et al.  Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma. , 1996, American journal of respiratory and critical care medicine.

[101]  P. Macklem A theoretical analysis of the effect of airway smooth muscle load on airway narrowing. , 1996, American journal of respiratory and critical care medicine.

[102]  D. Dusser,et al.  Airway responsiveness to bradykinin is related to eosinophilic inflammation in asthma. , 1996, American journal of respiratory and critical care medicine.

[103]  D. Yates,et al.  Inhaled glucocorticoids decrease nitric oxide in exhaled air of asthmatic patients. , 1996, American journal of respiratory and critical care medicine.

[104]  L. Fabbri,et al.  Comparison of leukocyte counts in sputum, bronchial biopsies, and bronchoalveolar lavage. , 1995, American journal of respiratory and critical care medicine.

[105]  D. Koller,et al.  Clinical value of monitoring eosinophil activity in asthma. , 1995, Archives of disease in childhood.

[106]  H. Boushey,et al.  Comparison of samples collected by sputum induction and bronchoscopy from asthmatic and healthy subjects. , 1995, American journal of respiratory and critical care medicine.

[107]  S. Dahlén,et al.  Validation and application of a new simple strategy for measurements of urinary leukotriene E4 in humans , 1995, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[108]  H. Garewal,et al.  Cigarette smoking and ethane exhalation in humans. , 1995, American journal of respiratory and critical care medicine.

[109]  Kwang Woo Kim,et al.  Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation. , 1995, The Journal of allergy and clinical immunology.

[110]  R. Vaughan,et al.  Evaluation of serum eosinophilic cationic protein as a marker of disease activity in chronic asthma. , 1995, The Journal of allergy and clinical immunology.

[111]  M. Jordana,et al.  Granulocyte-macrophage colony-stimulating factor, eosinophils and eosinophil cationic protein in subjects with and without mild, stable, atopic asthma. , 1994, The European respiratory journal.

[112]  P. J. Barnes,et al.  Increased nitric oxide in exhaled air of asthmatic patients , 1994, The Lancet.

[113]  H. Black,et al.  Expired breath hydrogen peroxide is a marker of acute airway inflammation in pediatric patients with asthma. , 1993, The American review of respiratory disease.

[114]  E. Weitzberg,et al.  Increased amount of nitric oxide in exhaled air of asthmatics. , 1993, The European respiratory journal.

[115]  R. S. Zimmerman,et al.  Total blood eosinophils, serum eosinophil cationic protein and eosinophil protein X in childhood asthma: relation to disease status and therapy , 1993, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[116]  J. Hogg,et al.  Functional significance of increased airway smooth muscle in asthma and COPD. , 1993, Journal of applied physiology.

[117]  H. Boushey,et al.  Cellular and biochemical analysis of induced sputum from asthmatic and from healthy subjects. , 1993, The American review of respiratory disease.

[118]  K. Lai,et al.  Serum concentration of soluble interleukin 2 receptors in asthma. Correlation with disease activity. , 1993, Chest.

[119]  S. Durham,et al.  Increases in activated T lymphocytes, eosinophils, and cytokine mRNA expression for interleukin-5 and granulocyte/macrophage colony-stimulating factor in bronchial biopsies after allergen inhalation challenge in atopic asthmatics. , 1993, American journal of respiratory cell and molecular biology.

[120]  T. Haahtela,et al.  A comparative study of the effects of an inhaled corticosteroid, budesonide, and a beta 2-agonist, terbutaline, on airway inflammation in newly diagnosed asthma: a randomized, double-blind, parallel-group controlled trial. , 1992, The Journal of allergy and clinical immunology.

[121]  A. Capron,et al.  Levels of soluble IL‐2 receptor in plasma from asthmatics. Correlations with blood eosinophilia, lung function, and corticosteroid therapy , 1992, Clinical and experimental immunology.

[122]  P. Howarth,et al.  Quantitation of mast cells and eosinophils in the bronchial mucosa of symptomatic atopic asthmatics and healthy control subjects using immunohistochemistry. , 1991, The American review of respiratory disease.

[123]  P. Venge,et al.  The effect of immunotherapy on bronchial hyperresponsiveness and eosinophil cationic protein in pollen-allergic patients. , 1988, The Journal of allergy and clinical immunology.