Lipolysis supports bone formation by providing osteoblasts with endogenous fatty acid substrates to maintain bioenergetic status

[1]  Arwa R. Althaher An Overview of Hormone-Sensitive Lipase (HSL) , 2022, TheScientificWorldJournal.

[2]  Lydia W. S. Finley,et al.  Regulation and function of the mammalian tricarboxylic acid cycle , 2022, The Journal of biological chemistry.

[3]  G. He,et al.  Dysregulated lipolysis and lipophagy in lipid droplets of macrophages from high fat diet‐fed obese mice , 2022, Journal of cellular and molecular medicine.

[4]  I. Lambrinoudaki,et al.  Bone Health in Patients with Dyslipidemias: An Underestimated Aspect , 2022, International journal of molecular sciences.

[5]  B. Misra,et al.  Untargeted metabolomics in primary murine bone marrow stromal cells reveals distinct profile throughout osteoblast differentiation , 2021, Metabolomics.

[6]  Xun Huang,et al.  Cytosolic lipolysis in non‐adipose tissues: energy provision and beyond , 2021, The FEBS journal.

[7]  V. Mlitz,et al.  Hepatocyte‐specific deletion of adipose triglyceride lipase (adipose triglyceride lipase/patatin‐like phospholipase domain containing 2) ameliorates dietary induced steatohepatitis in mice , 2021, Hepatology.

[8]  S. Burgess,et al.  Ins and Outs of the TCA Cycle: The Central Role of Anaplerosis. , 2021, Annual review of nutrition.

[9]  K. Kaiyala Review of Measuring Metabolic Rates: A Manual for Scientists , 2021, Physiological and Biochemical Zoology.

[10]  S. Maurya,et al.  Short-Chain Fatty Acids Outpace Ketone Oxidation in the Failing Heart , 2021, Circulation.

[11]  Ryan J Schulze,et al.  Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes , 2019, The Journal of cell biology.

[12]  A. Giaccia,et al.  HILPDA Regulates Lipid Metabolism, Lipid Droplet Abundance, and Response to Microenvironmental Stress in Solid Tumors , 2019, Molecular Cancer Research.

[13]  T. Okada,et al.  Osteoblastic lysosome plays a central role in mineralization , 2019, Science Advances.

[14]  L. Poll,et al.  Gaucher Disease in Bone: From Pathophysiology to Practice , 2019, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[15]  Sheng-Cai Lin,et al.  AMPK: Sensing Glucose as well as Cellular Energy Status. , 2017, Cell metabolism.

[16]  R. Shaw,et al.  AMPK: guardian of metabolism and mitochondrial homeostasis , 2017, Nature Reviews Molecular Cell Biology.

[17]  Caitlyn E. Bowman,et al.  Fatty acid oxidation by the osteoblast is required for normal bone acquisition in a sex- and diet-dependent manner. , 2017, JCI insight.

[18]  C. Rosen,et al.  Intracellular lipid droplets support osteoblast function , 2017, Adipocyte.

[19]  P. Puchalska,et al.  Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics. , 2017, Cell metabolism.

[20]  G. D’Arcangelo,et al.  Adenosine Triphosphate stimulates differentiation and mineralization in human osteoblast‐like Saos‐2 cells , 2016, Development, growth & differentiation.

[21]  Emily B. Mardian,et al.  Data on oxygen consumption rate, respiratory exchange ratio, and movement in C57BL/6J female mice on the third day of consuming a high-fat diet , 2016, Data in brief.

[22]  Ryan J Schulze,et al.  Hdac3 Deficiency Increases Marrow Adiposity and Induces Lipid Storage and Glucocorticoid Metabolism in Osteochondroprogenitor Cells , 2016, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[23]  P. Cerri,et al.  Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells , 2015, BioMed research international.

[24]  J. Lippincott-Schwartz,et al.  Fatty acid trafficking in starved cells: regulation by lipid droplet lipolysis, autophagy, and mitochondrial fusion dynamics. , 2015, Developmental cell.

[25]  C. Farber,et al.  Wnt-Lrp5 Signaling Regulates Fatty Acid Metabolism in the Osteoblast , 2015, Molecular and Cellular Biology.

[26]  D. Guertin,et al.  Highly Selective In Vivo Labeling of Subcutaneous White Adipocyte Precursors with Prx1-Cre , 2015, Stem cell reports.

[27]  B. Feldman,et al.  Characterization of Cre Recombinase Activity for In Vivo Targeting of Adipocyte Precursor Cells , 2014, Stem cell reports.

[28]  K. Jepsen,et al.  Biomechanical Mechanisms: Resolving the Apparent Conundrum of Why Individuals With Type II Diabetes Show Increased Fracture Incidence Despite Having Normal BMD , 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[29]  C. Farber,et al.  Bioenergetics during calvarial osteoblast differentiation reflect strain differences in bone mass. , 2014, Endocrinology.

[30]  L. Brissette,et al.  Low-Bone-Mass Phenotype of Deficient Mice for the Cluster of Differentiation 36 (CD36) , 2013, PloS one.

[31]  Petra C. Kienesberger,et al.  Skeletal Muscle Triacylglycerol Hydrolysis Does Not Influence Metabolic Complications of Obesity , 2013, Diabetes.

[32]  E. Esen,et al.  WNT-LRP5 signaling induces Warburg effect through mTORC2 activation during osteoblast differentiation. , 2013, Cell metabolism.

[33]  R. Schugar,et al.  Ketone body metabolism and cardiovascular disease. , 2013, American journal of physiology. Heart and circulatory physiology.

[34]  J. Kanis,et al.  Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee , 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[35]  J. Godbold,et al.  Skeletal manifestations in pediatric and adult patients with Niemann Pick disease type B , 2013, Journal of Inherited Metabolic Disease.

[36]  P. Carlsson,et al.  Female Mice are Protected against High-Fat Diet Induced Metabolic Syndrome and Increase the Regulatory T Cell Population in Adipose Tissue , 2012, PloS one.

[37]  Petra C. Kienesberger,et al.  ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1 , 2011, Nature Medicine.

[38]  Xu Feng,et al.  Disorders of bone remodeling. , 2011, Annual review of pathology.

[39]  G. Burnstock,et al.  Purinergic signalling and bone remodelling. , 2010, Current opinion in pharmacology.

[40]  Hideo Orimo,et al.  The mechanism of mineralization and the role of alkaline phosphatase in health and disease. , 2010, Journal of Nippon Medical School = Nippon Ika Daigaku zasshi.

[41]  Li Sun,et al.  Coupling bone degradation to formation , 2009, Nature Medicine.

[42]  C. Dani,et al.  Contribution of Adipose Triglyceride Lipase and Hormone-sensitive Lipase to Lipolysis in hMADS Adipocytes* , 2009, The Journal of Biological Chemistry.

[43]  T. Therneau,et al.  Fracture Risk in Type 2 Diabetes: Update of a Population‐Based Study , 2008, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[44]  John R. B. Lighton,et al.  Measuring Metabolic Rates , 2008 .

[45]  T. Plesner,et al.  A physical mechanism for coupling bone resorption and formation in adult human bone. , 2008, The American journal of pathology.

[46]  Mone Zaidi,et al.  Skeletal remodeling in health and disease , 2007, Nature Medicine.

[47]  W. Willett,et al.  Prospective Study of Diabetes and Risk of Hip Fracture , 2006, Diabetes Care.

[48]  J. Lacey,et al.  A prospective study of changes in bone turnover and bone density associated with regaining weight in women with anorexia nervosa , 2005, Osteoporosis International.

[49]  A. Hofman,et al.  Bone mineral density and fracture risk in type-2 diabetes mellitus: the Rotterdam Study. , 2005, Osteoporosis International.

[50]  R. Alippi,et al.  Bone status in an animal model of chronic sub-optimal nutrition: a morphometric, densitometric and mechanical study. , 2005, The British journal of nutrition.

[51]  G. Stein,et al.  SWI/SNF chromatin remodeling complex is obligatory for BMP2‐induced, Runx2‐dependent skeletal gene expression that controls osteoblast differentiation , 2005, Journal of cellular biochemistry.

[52]  Bing Liu,et al.  Isolation of Mouse Marrow Mesenchymal Progenitors by a Novel and Reliable Method , 2003, Stem cells.

[53]  Gwo‐Jaw Wang,et al.  Alcohol-Induced Adipogenesis in Bone and Marrow: A Possible Mechanism for Osteonecrosis , 2003, Clinical orthopaedics and related research.

[54]  A. Mobasheri,et al.  ATPase pumps in osteoclasts and osteoblasts. , 2002, The international journal of biochemistry & cell biology.

[55]  A. Folsom,et al.  Type 1 and type 2 diabetes and incident hip fractures in postmenopausal women. , 2001, Diabetes care.

[56]  Gene Kopen,et al.  Plastic adherent stromal cells from the bone marrow of commonly used strains of inbred mice: Variations in yield, growth, and differentiation , 1999, Journal of cellular biochemistry.

[57]  M. Drezner,et al.  Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee , 1987 .

[58]  H. Fleisch,et al.  Fatty acid oxidation in bone tissue and bone cells in culture. Characterization and hormonal influences. , 1987, The Biochemical journal.

[59]  M. Nussbaum,et al.  Short stature in anorexia nervosa patients. , 1985, Journal of adolescent health care : official publication of the Society for Adolescent Medicine.

[60]  K. Hirohata,et al.  Steroid-induced accumulation of lipid in the osteocytes of the rabbit femoral head. A histochemical and electron microscopic study. , 1985, The Journal of bone and joint surgery. American volume.

[61]  A. Halestrap Pyruvate and ketone-body transport across the mitochondrial membrane. Exchange properties, pH-dependence and mechanism of the carrier. , 1978, The Biochemical journal.

[62]  D. V. Cohn,et al.  Aerobic metabolism of glucose by bone. , 1962, The Journal of biological chemistry.

[63]  W. J. Dyer,et al.  A rapid method of total lipid extraction and purification. , 1959, Canadian journal of biochemistry and physiology.

[64]  Brian T Palmisano,et al.  Role of Estrogens in the Regulation of Liver Lipid Metabolism. , 2017, Advances in experimental medicine and biology.

[65]  R. O’Keefe,et al.  Isolation and culture of neonatal mouse calvarial osteoblasts. , 2014, Methods in molecular biology.

[66]  P. Lips,et al.  Body composition and bone measurements in intra-uterine growth retarded and early postnatally undernourished male and female rats at the age of 6 months: comparison with puberty. , 2004, Bone.

[67]  R. Brommage,et al.  Aerobic glycolysis in bone: lactate production and gradients in calvaria. , 1978, The American journal of physiology.

[68]  D. Enlow,et al.  Observations on the occurrence and the distribution of lipids in compact bone. , 1965, Clinical orthopaedics and related research.

[69]  JoVE Video Dataset , 2022 .

[70]  Printed in U.S.A. Copyright © 2003 by The Endocrine Society doi: 10.1210/en.2003-0982 Minireview: The AMP-Activated Protein Kinase Cascade: The Key Sensor of Cellular Energy Status , 2022 .