BNIP-Sα induces cell rounding and apoptosis by displacing p50RhoGAP and facilitating RhoA activation via its unique motifs in the BNIP-2 and Cdc42GAP homology domain

[1]  Kevin A. Burns,et al.  Cdc42GAP regulates c-Jun N-terminal kinase (JNK)-mediated apoptosis and cell number during mammalian perinatal growth. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[2]  K. Ayscough,et al.  Identification of an upstream regulatory pathway controlling actin-mediated apoptosis in yeast , 2005, Journal of Cell Science.

[3]  M. Ikebe,et al.  BIG1 Is a Binding Partner of Myosin IXb and Regulates Its Rho-GTPase Activating Protein Activity* , 2005, Journal of Biological Chemistry.

[4]  G. Guy,et al.  BNIP-2 induces cell elongation and membrane protrusions by interacting with Cdc42 via a unique Cdc42-binding motif within its BNIP-2 and Cdc42GAP homology domain. , 2005, Experimental cell research.

[5]  C. Stewart,et al.  Actin-myosin–based contraction is responsible for apoptotic nuclear disintegration , 2005, The Journal of cell biology.

[6]  Mohammad Reza Ahmadian,et al.  Always look on the bright site of Rho: structural implications for a conserved intermolecular interface , 2004, EMBO reports.

[7]  S. Narumiya,et al.  Galphaq/11 signaling induces apoptosis through two pathways involving reduction of Akt phosphorylation and activation of RhoA in HeLa cells. , 2004, Experimental cell research.

[8]  H. Heller,et al.  RhoA controls myoblast survival by inducing the phosphatidylinositol 3‐kinase‐Akt signaling pathway , 2004, FEBS letters.

[9]  B. C. Low,et al.  BPGAP1 interacts with cortactin and facilitates its translocation to cell periphery for enhanced cell migration. , 2004, Molecular biology of the cell.

[10]  John G. Collard.  Cancer: Kip moving , 2004, Nature.

[11]  R. Lockshin,et al.  Caspase-independent cell death? , 2004, Oncogene.

[12]  G. Davis,et al.  Microtubule Depolymerization Rapidly Collapses Capillary Tube Networks in Vitro and Angiogenic Vessels in Vivo through the Small GTPase Rho* , 2004, Journal of Biological Chemistry.

[13]  S. Thorgeirsson,et al.  Restoration of DLC-1 gene expression induces apoptosis and inhibits both cell growth and tumorigenicity in human hepatocellular carcinoma cells , 2004, Oncogene.

[14]  M. Mendelsohn,et al.  Myosin Phosphatase-Rho Interacting Protein , 2003, Journal of Biological Chemistry.

[15]  K. Ravichandran,et al.  Engulfment of Apoptotic Cells Is Negatively Regulated by Rho-mediated Signaling* , 2003, Journal of Biological Chemistry.

[16]  Rong Li,et al.  Mitochondrial translocation of cofilin is an early step in apoptosis induction , 2003, Nature Cell Biology.

[17]  B. C. Low,et al.  Concerted Regulation of Cell Dynamics by BNIP-2 and Cdc42GAP Homology/Sec14p-like, Proline-rich, and GTPase-activating Protein Domains of a Novel Rho GTPase-activating Protein, BPGAP1* , 2003, Journal of Biological Chemistry.

[18]  Sang-Gu Hwang,et al.  Actin Cytoskeletal Architecture Regulates Nitric Oxide-induced Apoptosis, Dedifferentiation, and Cyclooxygenase-2 Expression in Articular Chondrocytes via Mitogen-activated Protein Kinase and Protein Kinase C Pathways* , 2003, Journal of Biological Chemistry.

[19]  Jinjun Li,et al.  BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis. , 2003, Biochemical and Biophysical Research Communications - BBRC.

[20]  L. Mckerracher,et al.  Rho activation patterns after spinal cord injury and the role of activated Rho in apoptosis in the central nervous system , 2003, The Journal of cell biology.

[21]  J. Settleman,et al.  Rnd Proteins Function as RhoA Antagonists by Activating p190 RhoGAP , 2003, Current Biology.

[22]  T. Yamashita,et al.  The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI , 2003, Nature Neuroscience.

[23]  Y. Qiu,et al.  Selective Activation of Small GTPase RhoA by Tyrosine Kinase Etk through Its Pleckstrin Homology Domain* , 2002, The Journal of Biological Chemistry.

[24]  D. Chang,et al.  ROCK-II-induced membrane blebbing and chromatin condensation require actin cytoskeleton. , 2002, Experimental cell research.

[25]  M. Coleman,et al.  Rho GTPase signalling pathways in the morphological changes associated with apoptosis , 2002, Cell Death and Differentiation.

[26]  G. Guy,et al.  The BNIP-2 and Cdc42GAP Homology/Sec14p-like Domain of BNIP-Sα Is a Novel Apoptosis-inducing Sequence* , 2002, The Journal of Biological Chemistry.

[27]  P. McPherson,et al.  The Activity of the GTPase-activating Protein CdGAP Is Regulated by the Endocytic Protein Intersectin* , 2002, The Journal of Biological Chemistry.

[28]  E. Sahai,et al.  RHO–GTPases and cancer , 2002, Nature Reviews Cancer.

[29]  Yasunobu Miyake,et al.  Actin cytoskeleton is required for early apoptosis signaling induced by anti-Fas antibody but not Fas ligand in murine B lymphoma A20 cells. , 2002, Biochemical and biophysical research communications.

[30]  S H Kaufmann,et al.  Programmed cell death: alive and well in the new millennium. , 2001, Trends in cell biology.

[31]  A. Ridley,et al.  Rho family proteins: coordinating cell responses. , 2001, Trends in cell biology.

[32]  D E Ingber,et al.  Cooperative control of Akt phosphorylation, bcl-2 expression, and apoptosis by cytoskeletal microfilaments and microtubules in capillary endothelial cells. , 2001, Molecular biology of the cell.

[33]  J. Lacal,et al.  Rho signals to cell growth and apoptosis. , 2001, Cancer letters.

[34]  K. Rabe,et al.  Initiation of apoptosis by actin cytoskeletal derangement in human airway epithelial cells. , 2001, American journal of respiratory cell and molecular biology.

[35]  G. Guy,et al.  The BNIP-2 and Cdc42GAP Homology Domain of BNIP-2 Mediates Its Homophilic Association and Heterophilic Interaction with Cdc42GAP* , 2000, The Journal of Biological Chemistry.

[36]  G. Guy,et al.  Sprouty Proteins Are Targeted to Membrane Ruffles upon Growth Factor Receptor Tyrosine Kinase Activation , 2000, The Journal of Biological Chemistry.

[37]  A. Hall,et al.  Rho GTPases and their effector proteins. , 2000, The Biochemical journal.

[38]  G. Guy,et al.  Evidence for a Novel Cdc42GAP Domain at the Carboxyl Terminus of BNIP-2* , 2000, The Journal of Biological Chemistry.

[39]  K. Hahn,et al.  Rho Family Proteins Modulate Rapid Apoptosis Induced by Cytotoxic T Lymphocytes and Fas* , 2000, The Journal of Biological Chemistry.

[40]  C Combet,et al.  NPS@: network protein sequence analysis. , 2000, Trends in biochemical sciences.

[41]  Y. Lim,et al.  Tyrosine Phosphorylation of the Bcl-2-associated Protein BNIP-2 by Fibroblast Growth Factor Receptor-1 Prevents Its Binding to Cdc42GAP and Cdc42* , 1999, The Journal of Biological Chemistry.

[42]  D. Kelvin,et al.  Cytoskeletal disruption induces T cell apoptosis by a caspase-3 mediated mechanism. , 1999, Life sciences.

[43]  J. Mills,et al.  Extranuclear Apoptosis , 1999, The Journal of cell biology.

[44]  E. Gelfand,et al.  Microfilament assembly is involved in B-cell apoptosis. , 1999, Cellular immunology.

[45]  B. Bierer,et al.  Actin Stabilization by Jasplakinolide Enhances Apoptosis Induced by Cytokine Deprivation* , 1999, The Journal of Biological Chemistry.

[46]  P. Aspenström.  The Rho GTPases have multiple effects on the actin cytoskeleton. , 1999, Experimental cell research.

[47]  Jacques Landry,et al.  SAPK2/p38-dependent F-Actin Reorganization Regulates Early Membrane Blebbing during Stress-induced Apoptosis , 1998, The Journal of cell biology.

[48]  C. Fiorentini,et al.  Toxin-induced activation of Rho GTP-binding protein increases Bcl-2 expression and influences mitochondrial homeostasis. , 1998, Experimental cell research.

[49]  C. Fiorentini,et al.  Clostridium difficile Toxin B Induces Apoptosis in Intestinal Cultured Cells , 1998, Infection and Immunity.

[50]  A. Hall,et al.  Rho GTPases and the actin cytoskeleton. , 1998, Science.

[51]  C. Hahn,et al.  Inactivation of the small GTPase Rho disrupts cellular attachment and induces adhesion-dependent and adhesion-independent apoptosis , 1997, Oncogene.

[52]  A. Mammoto,et al.  Direct Interaction of the Rho GDP Dissociation Inhibitor with Ezrin/Radixin/Moesin Initiates the Activation of the Rho Small G Protein* , 1997, The Journal of Biological Chemistry.

[53]  J. M. Boyd,et al.  Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins , 1994, Cell.

[54]  David A. Williams,et al.  Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem/progenitor cell survival, adhesion, and engraftment. , 2006, Blood.

[55]  Yi Zheng,et al.  Rho GTPase-activating proteins in cell regulation. , 2003, Trends in cell biology.

[56]  Robert D. Goldman,et al.  Cells: a laboratory manual , 1997 .