Genomic and transcriptomic profiling expands precision cancer medicine: the WINTHER trial
暂无分享,去创建一个
J Jack Lee | Eitan Rubin | Razelle Kurzrock | Jordi Rodon | Richard L Schilsky | Aleksandra Kugel | Pierre Saintigny | Vincent Miller | John Mendelsohn | Gerald Batist | Jacques Raynaud | Irene Braña | Josep Tabernero | R. Schilsky | J. Lee | R. Berger | V. Miller | J. Tabernero | W. Miller | R. Kurzrock | V. Lazar | G. Batist | J. Soria | I. Braña | J. Mendelsohn | A. Tsimberidou | P. Saintigny | M. Afshar | E. Rubin | J. Martini | A. Onn | C. Bresson | Y. Loriot | Yohann Loriot | Jean-Charles Soria | Vladimir Lazar | Wilson H Miller | Raanan Berger | Apostolia Tsimberidou | Aliza Ackerstein | Mohammad Afshar | Fanny Wunder | Catherine Bresson | Jean-François Martini | Amir Onn | A. Ackerstein | A. Kugel | J. Rodón | F. Wunder | J. Raynaud | J. Lee | Wilson H. Miller | J. J. Lee | J. Lee
[1] Michael Bittner,et al. Pilot study using molecular profiling of patients' tumors to find potential targets and select treatments for their refractory cancers. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[2] J. Lee,et al. PIK3CA Mutations Frequently Coexist with RAS and BRAF Mutations in Patients with Advanced Cancers , 2011, PloS one.
[3] S. Lippman,et al. Precision Oncology: The UC San Diego Moores Cancer Center PREDICT Experience , 2016, Molecular Cancer Therapeutics.
[4] Razelle Kurzrock,et al. Personalized Medicine in a Phase I Clinical Trials Program: The MD Anderson Cancer Center Initiative , 2012, Clinical Cancer Research.
[5] Marie-Cécile Le Deley,et al. High-Throughput Genomics and Clinical Outcome in Hard-to-Treat Advanced Cancers: Results of the MOSCATO 01 Trial. , 2017, Cancer discovery.
[6] J. Tabernero,et al. Development of PI3K inhibitors: lessons learned from early clinical trials , 2013, Nature Reviews Clinical Oncology.
[7] A. D. Van den Abbeele,et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. , 2002, The New England journal of medicine.
[8] R. Yelensky,et al. Cancer Therapy Directed by Comprehensive Genomic Profiling: A Single Center Study. , 2016, Cancer research.
[9] P. Campbell,et al. Somatic mutation in cancer and normal cells , 2015, Science.
[10] A. Hauschild,et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. , 2011, The New England journal of medicine.
[11] Benjamin J. Raphael,et al. Mutational landscape and significance across 12 major cancer types , 2013, Nature.
[12] J. Ioannidis. Why Most Published Research Findings Are False , 2005 .
[13] J Jack Lee,et al. Impact of Precision Medicine in Diverse Cancers: A Meta-Analysis of Phase II Clinical Trials. , 2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[14] K. Hess,et al. Initiative for Molecular Profiling and Advanced Cancer Therapy (IMPACT): An MD Anderson Precision Medicine Study. , 2017, JCO precision oncology.
[15] Alex M. Fichtenholtz,et al. Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing , 2013, Nature Biotechnology.
[16] Razelle Kurzrock,et al. Association of Biomarker-Based Treatment Strategies With Response Rates and Progression-Free Survival in Refractory Malignant Neoplasms: A Meta-analysis. , 2016, JAMA oncology.
[17] F. Schmidt. Meta-Analysis , 2008 .
[18] S. Lippman,et al. Utility of Genomic Analysis In Circulating Tumor DNA from Patients with Carcinoma of Unknown Primary. , 2017, Cancer research.
[19] Y. Benjamini,et al. Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .
[20] R. Schilsky,et al. Challenges in initiating and conducting personalized cancer therapy trials: perspectives from WINTHER, a Worldwide Innovative Network (WIN) Consortium trial. , 2015, Annals of oncology : official journal of the European Society for Medical Oncology.
[21] J. Lee,et al. Target-Based Therapeutic Matching in Early-Phase Clinical Trials in Patients with Advanced Colorectal Cancer and PIK3CA Mutations , 2013, Molecular Cancer Therapeutics.
[22] S. Koscielny. Why Most Gene Expression Signatures of Tumors Have Not Been Useful in the Clinic , 2010, Science Translational Medicine.
[23] Razelle Kurzrock,et al. PI3K/AKT/mTOR inhibitors in patients with breast and gynecologic malignancies harboring PIK3CA mutations. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[24] S. Millis,et al. Next-Generation Sequencing in the Clinical Setting Clarifies Patient Characteristics and Potential Actionability. , 2017, Cancer research.
[25] F. Cappuzzo,et al. First-line crizotinib versus chemotherapy in ALK-positive lung cancer. , 2014, The New England journal of medicine.
[26] R. Kurzrock,et al. Biomarker-directed therapy of squamous carcinomas of the head and neck: targeting PI3K/PTEN/mTOR pathway. , 2013, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[27] Pierre Validire,et al. A simplified interventional mapping system (SIMS) for the selection of combinations of targeted treatments in non-small cell lung cancer , 2015, Oncotarget.
[28] P. Stephens,et al. Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers , 2017, Molecular Cancer Therapeutics.
[29] B. Freidlin,et al. RE: Impact of a Biomarker-Based Strategy on Oncology Drug Development: A Meta-analysis of Clinical Trials Leading to FDA Approval. , 2016, Journal of the National Cancer Institute.
[30] R. Schilsky,et al. Impact of a Biomarker-Based Strategy on Oncology Drug Development: A Meta-analysis of Clinical Trials Leading to FDA Approval. , 2015, Journal of the National Cancer Institute.
[31] Ludmila V. Danilova,et al. Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade , 2017, Science.
[32] Razelle Kurzrock,et al. Assessing PIK3CA and PTEN in early-phase trials with PI3K/AKT/mTOR inhibitors. , 2014, Cell reports.
[33] William Pao,et al. Dual inhibition of EGFR with afatinib and cetuximab in kinase inhibitor-resistant EGFR-mutant lung cancer with and without T790M mutations. , 2014, Cancer discovery.
[34] Nicolas Servant,et al. Molecularly targeted therapy based on tumour molecular profiling versus conventional therapy for advanced cancer (SHIVA): a multicentre, open-label, proof-of-concept, randomised, controlled phase 2 trial. , 2015, The Lancet. Oncology.
[35] Michael Bryce,et al. Test 5.14.4. Deposit 18 June 15:43, embargoed 18/07/2019 : Article -> Review article , 2019 .
[36] P. A. Futreal,et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. , 2012, The New England journal of medicine.
[37] Razelle Kurzrock,et al. PIK3CA Mutations in Advanced Cancers: Characteristics and Outcomes , 2012, Oncotarget.
[38] J. Lee,et al. PIK3CA mutation H1047R is associated with response to PI3K/AKT/mTOR signaling pathway inhibitors in early-phase clinical trials. , 2013, Cancer research.
[39] Lesley Seymour,et al. Erlotinib in lung cancer - molecular and clinical predictors of outcome. , 2005, The New England journal of medicine.
[40] R. Kurzrock,et al. KRASness and PIK3CAness in Patients with Advanced Colorectal Cancer: Outcome after Treatment with Early-Phase Trials with Targeted Pathway Inhibitors , 2012, PloS one.
[41] Chris Sander,et al. Emerging landscape of oncogenic signatures across human cancers , 2013, Nature Genetics.
[42] James C Yao,et al. Everolimus for the treatment of advanced, non-functional neuroendocrine tumours of the lung or gastrointestinal tract (RADIANT-4): a randomised, placebo-controlled, phase 3 study , 2016, The Lancet.