Wireless Capsule Endoscope for Targeted Drug Delivery: Mechanics and Design Considerations

This paper describes a platform to achieve targeted drug delivery in the next-generation wireless capsule endoscopy. The platform consists of two highly novel subsystems: one is a micropositioning mechanism which can deliver 1 ml of targeted medication and the other is a holding mechanism, which gives the functionality of resisting peristalsis. The micropositioning mechanism allows a needle to be positioned within a 22.5° segment of a cylindrical capsule and be extendible by up to 1.5 mm outside the capsule body. The mechanism achieves both these functions using only a single micromotor and occupying a total volume of just 200 mm3. The holding mechanism can be deployed diametrically opposite the needle in 1.8 s and occupies a volume of just 270 mm3. An in-depth analysis of the mechanics is presented and an overview of the requirements necessary to realize a total system integration is discussed. It is envisaged that the targeted drug delivery platform will empower a new breed of capsule microrobots for therapy in addition to diagnostics for pathologies such as ulcerative colitis and small intestinal Crohn's disease.

[1]  H. Gray.  Gray's Anatomy , 1858 .

[2]  Hirst,et al.  Development of a new engineering-based capsule for human drug absorption studies. , 2000, Pharmaceutical science & technology today.

[3]  G. Meron.  The development of the swallowable video capsule (M2A). , 2000, Gastrointestinal endoscopy.

[4]  D. Fischer,et al.  Capsule endoscopy: the localization system. , 2004, Gastrointestinal endoscopy clinics of North America.

[5]  P. Swain,et al.  Role of video endoscopy in managing small bowel disease , 2004, Gut.

[6]  L. Pizzi,et al.  Diagnosing Crohn's disease: an economic analysis comparing wireless capsule endoscopy with traditional diagnostic procedures. , 2004, Disease management : DM.

[7]  M.Q.-H. Meng,et al.  Physiological Factors of the Small Intestine in Design of Active Capsule Endoscopy , 2005, 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference.

[8]  Roustem Miftahof,et al.  The Wave Phenomena in Smooth Muscle Syncytia , 2005, Silico Biol..

[9]  M. Meng,et al.  A Localization Method Using 3-axis Magnetoresistive Sensors for Tracking of Capsule Endoscope , 2006, 2006 International Conference of the IEEE Engineering in Medicine and Biology Society.

[10]  Guolin Li,et al.  A Low-Power Digital IC Design Inside the Wireless Endoscopic Capsule , 2006, IEEE Journal of Solid-State Circuits.

[11]  Federico Carpi,et al.  Controlled Navigation of Endoscopic Capsules: Concept and Preliminary Experimental Investigations , 2007, IEEE Transactions on Biomedical Engineering.

[12]  Jong-Oh Park,et al.  Paddling based Microrobot for Capsule Endoscopes , 2007, Proceedings 2007 IEEE International Conference on Robotics and Automation.

[13]  Zhihua Wang,et al.  Low-Power Transceiver Analog Front-End Circuits for Bidirectional High Data Rate Wireless Telemetry in Medical Endoscopy Applications , 2007, IEEE Transactions on Biomedical Engineering.

[14]  D. Faigel,et al.  A multicenter randomized comparison of the Endocapsule and the Pillcam SB. , 2008, Gastrointestinal endoscopy.

[15]  Paolo Dario,et al.  A New Mechanism for Mesoscale Legged Locomotion in Compliant Tubular Environments , 2009, IEEE Transactions on Robotics.

[16]  David E. Martin,et al.  An Oral Human Drug Absorption Study to Assess the Impact of Site of Delivery on the Bioavailability of Bevirimat , 2009, Journal of clinical pharmacology.

[17]  A. Forgione.  In vivo microrobots for natural orifice transluminal surgery. Current status and future perspectives. , 2009, Surgical oncology.

[18]  Jin-Ho Cho,et al.  Stopping mechanism for capsule endoscope using electrical stimulus , 2009, Medical & Biological Engineering & Computing.

[19]  Zhihua Wang,et al.  A Wireless Capsule Endoscope System With Low-Power Controlling and Processing ASIC , 2009, IEEE Transactions on Biomedical Circuits and Systems.

[20]  R. Webster,et al.  Swallowable medical devices for diagnosis and surgery: The state of the art , 2010 .

[21]  Timothy G. Constandinou,et al.  Towards a micropositioning system for targeted drug delivery in wireless capsule endoscopy , 2011, 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[22]  P. Dario,et al.  Capsule Endoscopy: From Current Achievements to Open Challenges , 2011, IEEE Reviews in Biomedical Engineering.

[23]  Weihua Li,et al.  A Review of Localization Systems for Robotic Endoscopic Capsules , 2012, IEEE Transactions on Biomedical Engineering.