Role of Epstein‐Barr virus status and immunophenotypic studies in the evaluation of exfoliative cytology specimens from patients with post‐transplant lymphoproliferative disorders

Post‐transplant lymphoproliferative disorders (PTLDs) are well characterized in tissue sections, but their evaluation in exfoliative cytology specimens is limited. This study reports a 25‐year experience with PTLDs in exfoliative cytology specimens.

[1]  S. Swerdlow WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues , 2017 .

[2]  L. Medeiros,et al.  Malignant effusions correlate with poorer prognosis in patients with diffuse large B-cell lymphoma. , 2015, American journal of clinical pathology.

[3]  H. Takei,et al.  Epstein-Barr virus-positive pleural effusion: Clinical features, cytomorphologic characteristics, and flow cytometric immunophenotyping. , 2014, American journal of clinical pathology.

[4]  E. Moore,et al.  Use of flow cytometry in the diagnosis of lymphoproliferative disorders in fluid specimens , 2014, Diagnostic cytopathology.

[5]  Y. Gong,et al.  From cytomorphology to molecular pathology: maximizing the value of cytology of lymphoproliferative disorders and soft tissue tumors. , 2013, American journal of clinical pathology.

[6]  A. Bagg,et al.  Immunosuppressive and immunomodulatory therapy-associated lymphoproliferative disorders. , 2013, Seminars in diagnostic pathology.

[7]  G. da Cunha Santos,et al.  Subclassification of lymphoproliferative disorders in serous effusions , 2013, Cancer cytopathology.

[8]  V. Anttila,et al.  Clinical characteristics of patients with Epstein Barr virus in cerebrospinal fluid , 2011, BMC infectious diseases.

[9]  H. Strik,et al.  CSF cytology—the ongoing dilemma to distinguish neoplastic and inflammatory lymphocytes , 2011, Diagnostic cytopathology.

[10]  S. Pauls,et al.  Cerebrospinal fluid pleocytosis , 2011, Cancer cytopathology.

[11]  S. Swerdlow,et al.  Flow cytometric immunophenotyping of cerebrospinal fluid specimens. , 2011, American journal of clinical pathology.

[12]  B. Brando,et al.  Flow cytometry vs cytomorphology for the detection of hematologic malignancy in body cavity fluids. , 2010, Leukemia research.

[13]  R. Marcus,et al.  Diagnosis of post‐transplant lymphoproliferative disorder in solid organ transplant recipients – BCSH and BTS Guidelines , 2010, British journal of haematology.

[14]  S. Baldi,et al.  Herpesviruses detection by quantitative real-time polymerase chain reaction in bronchoalveolar lavage and transbronchial biopsy in lung transplant: viral infections and histopathological correlation. , 2010, Transplantation proceedings.

[15]  M. Lowery-Nordberg,et al.  The role of fluorescence in situ hybridization and polymerase chain reaction in the diagnosis and classification of lymphoproliferative disorders on fine‐needle aspiration , 2010, Cancer cytopathology.

[16]  Scott E. Smith,et al.  Multicenter analysis of 80 solid organ transplantation recipients with post-transplantation lymphoproliferative disease: outcomes and prognostic factors in the modern era. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[17]  M. Mansukhani,et al.  KHSV− EBV− post‐transplant effusion lymphoma with plasmablastic features: variant of primary effusion lymphoma? , 2009, Hematological oncology.

[18]  D. Rosenthal,et al.  Lymphoma, leukemia, and pleiocytosis in cerebrospinal fluid: Is accurate cytopathologic diagnosis possible based on morphology alone? , 2009, Diagnostic cytopathology.

[19]  M. Gulley,et al.  Laboratory assays for Epstein-Barr virus-related disease. , 2008, The Journal of molecular diagnostics : JMD.

[20]  S. Webber,et al.  Screening for PTLD in lung and heart–lung transplant recipients by measuring EBV DNA load in bronchoalveolar lavage fluid using real time PCR , 2008, Pediatric transplantation.

[21]  M. M. Sales,et al.  Pleural Primary Effusion Lymphoma in a Renal Transplant Recipient , 2008, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[22]  H. Adle-Biassette,et al.  Human Herpesvirus‐8 (HHV‐8)‐Associated Primary Effusion Lymphoma in two Renal Transplant Recipients Receiving Rapamycin , 2008, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[23]  D. K. Das,et al.  Cytomorphological and immunocytochemical study of non‐Hodgkin's lymphoma in pleural effusion and ascitic fluid , 2007, Cytopathology : official journal of the British Society for Clinical Cytology.

[24]  B. Moulin,et al.  Post‐Transplant Lymphoproliferative Disorders Occurring After Renal Transplantation in Adults: Report of 230 Cases From the French Registry , 2006, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[25]  D. Das Serous effusions in malignant lymphomas: A review , 2006, Diagnostic cytopathology.

[26]  L. Skoog,et al.  Flow cytometric immunophenotyping including Bcl‐2 detection on fine needle aspirates in the diagnosis of reactive lymphadenopathy and non‐Hodgkin's lymphoma , 2005, Cytometry. Part B, Clinical cytometry.

[27]  G. Opelz,et al.  Lymphomas After Solid Organ Transplantation: A Collaborative Transplant Study Report , 2004, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[28]  M. Czader,et al.  Flow cytometry as an adjunct to cytomorphologic analysis of serous effusions , 2003, Diagnostic cytopathology.

[29]  G. Nuovo,et al.  Primary Effusion Lymphoma: Cytopathologic Diagnosis Using In Situ Molecular Genetic Analysis for Human Herpesvirus 8 , 2002, Modern Pathology.

[30]  V. Reddy,et al.  Anaplastic T large cell lymphoma diagnosed by exfoliative cytology in a post renal transplant patient , 2002, Diagnostic cytopathology.

[31]  S. Swerdlow,et al.  Primary pleural effusion posttransplant lymphoproliferative disorder: Distinction from secondary involvement and effusion lymphoma , 2001, Diagnostic cytopathology.

[32]  M. Bangerter,et al.  Combined Cytomorphologic and Immunophenotypic Analysis in the Diagnostic Workup of Lymphomatous Effusions , 2001, Acta Cytologica.

[33]  R. Braylan,et al.  Flow cytometric analysis of lymphomas and lymphoproliferative disorders. , 2001, Seminars in hematology.

[34]  A. Longatto-Filho,et al.  Immunocytochemical Study of Malignant Lymphoma in Serous Effusions , 2000, Acta Cytologica.

[35]  M. Stetler-Stevenson,et al.  Immunophenotypic analysis of non‐hodgkin's lymphomas in cytologic specimens: A correlative study of immunocytochemical and flow cytometric techniques , 1999, Diagnostic cytopathology.

[36]  T. Barbui,et al.  Primary effusion lymphoma after heart transplantation: a new entity associated with human herpesvirus-8 , 1999, Leukemia.

[37]  C. Rieux,et al.  Posttransplantation Lymphoproliferative Disorder Mimicking a Nonspecific Lymphocytic Pleural Effusion in a Bone Marrow Transplant Recipient , 1999, Acta Cytologica.

[38]  J. Aster,et al.  Primary-effusion lymphoma and Kaposi's sarcoma in a cardiac-transplant recipient. , 1998, The New England journal of medicine.

[39]  B. Vicandi,et al.  Posttransplant CD30 (Ki-1)-positive anaplastic large cell lymphoma. Report of a case with presentation as a pleural effusion. , 1997, Acta cytologica.

[40]  S. Swerdlow,et al.  Cytologic features of post‐transplant lymphoproliferative disorder , 1997, Diagnostic cytopathology.

[41]  V. Reddy,et al.  Posttransplant lymphoproliferative disorders: A fine‐needle aspiration biopsy study , 1997, Diagnostic cytopathology.

[42]  N. Harris,et al.  Posttransplant lymphoproliferative disorders: summary of Society for Hematopathology Workshop. , 1997, Seminars in diagnostic pathology.

[43]  E. Cesarman,et al.  Molecular pathology of posttransplantation lymphoproliferative disorders. , 1997, Seminars in diagnostic pathology.

[44]  V. Reddy,et al.  Role of fine‐needle aspiration in clinical management of transplant patients , 1996, Diagnostic cytopathology.

[45]  Y. Bryson,et al.  Massive pseudolymphomatous pericardial effusion in the posttransplant setting mimicking posttransplant lymphoproliferative disease. , 1996, Transplantation.

[46]  E. Cesarman,et al.  Correlative morphologic and molecular genetic analysis demonstrates three distinct categories of posttransplantation lymphoproliferative disorders. , 1995, Blood.

[47]  I. Weissman,et al.  Characterization of posttransplant lymphomas that express T-cell-associated markers: immunophenotypes, molecular genetics, cytogenetics, and heterotransplantation in severe combined immunodeficient mice. , 1993, Blood.

[48]  H. Stein,et al.  EBV infection patterns in Hodgkin's disease and normal lymphoid tissue: expression and cellular localization of EBV gene products , 1992, British journal of haematology.

[49]  M. Gulley,et al.  Cytologic findings in posttransplant lymphoproliferative disease. , 1990, Acta cytologica.

[50]  J. Krause,et al.  Posttransplant mediastinal Burkitt-like lymphoma. Diagnosis by cytologic and flow cytometric analysis of pleural fluid. , 1990, Acta cytologica.