Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization.
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[1] E. Rofstad,et al. Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice. , 2006, Cancer research.
[2] Tracy T Batchelor,et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. , 2007, Cancer cell.
[3] P. Abrams,et al. Radioimmunotherapy of Cancer , 2000 .
[4] S. Larson,et al. “Artificial Lymphatic System”: A New Approach to Reduce Interstitial Hypertension and Increase Blood Flow, pH and pO2 in Solid Tumors , 2000, Annals of Biomedical Engineering.
[5] R. Weinberg,et al. Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation. , 2001, Experimental cell research.
[6] M. Dewhirst,et al. Concepts of oxygen transport at the microcirculatory level. , 1998, Seminars in radiation oncology.
[7] Marc Dellian,et al. Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.
[8] Ricky T. Tong,et al. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer , 2004, Nature Medicine.
[9] R. Jain,et al. Delivery of Molecular and Cellular Medicine to Solid Tumors , 1997, Advanced drug delivery reviews.
[10] R. Jain,et al. Role of host microenvironment in angiogenesis and microvascular functions in human breast cancer xenografts: mammary fat pad versus cranial tumors. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.
[11] G. Semenza. Targeting HIF-1 for cancer therapy , 2003, Nature Reviews Cancer.
[12] R K Jain,et al. Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1alpha--> hypoxia response element--> VEGF cascade differentially regulates vascular response and growth rate in tumors. , 2000, Cancer research.
[13] R. Jain,et al. NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels. , 2005, The Journal of clinical investigation.
[14] C. Berking,et al. Function and regulation of melanoma–stromal fibroblast interactions: when seeds meet soil , 2003, Oncogene.
[15] P. Comoglio,et al. Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. , 2003, Cancer cell.
[16] Rakesh K Jain,et al. Lymphatic Metastasis in the Absence of Functional Intratumor Lymphatics , 2002, Science.
[17] R. Jain,et al. Acidic Extracellular pH Induces Vascular Endothelial Growth Factor (VEGF) in Human Glioblastoma Cells via ERK1/2 MAPK Signaling Pathway , 2002, The Journal of Biological Chemistry.
[18] R. Jain,et al. Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft. , 1994, Cancer research.
[19] Rakesh K. Jain,et al. Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy , 2001, Nature Medicine.
[20] R K Jain,et al. Determinants of tumor blood flow: a review. , 1988, Cancer research.
[21] R K Jain,et al. Quantitation and physiological characterization of angiogenic vessels in mice: effect of basic fibroblast growth factor, vascular endothelial growth factor/vascular permeability factor, and host microenvironment. , 1996, The American journal of pathology.
[22] R K Jain,et al. Mosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[23] R K Jain,et al. Effect of host microenvironment on the microcirculation of human colon adenocarcinoma. , 1997, The American journal of pathology.
[24] R. Jain,et al. Microvascular permeability of normal and neoplastic tissues. , 1986, Microvascular research.
[25] C. Compton,et al. Tumor–host interactions in the gallbladder suppress distal angiogenesis and tumor growth: Involvement of transforming growth factor β1 , 1999, Nature Medicine.
[26] R. Jain,et al. Tumor oxygenation in hormone-dependent tumors during vascular endothelial growth factor receptor-2 blockade, hormone ablation, and chemotherapy. , 2000, Cancer research.
[27] R. Jain,et al. Solid stress generated by spheroid growth estimated using a linear poroelasticity model. , 2003, Microvascular research.
[28] Rakesh K Jain,et al. A protocol for phenotypic detection and enumeration of circulating endothelial cells and circulating progenitor cells in human blood , 2007, Nature Protocols.
[29] Elise C. Kohn,et al. The microenvironment of the tumour–host interface , 2001, Nature.
[30] R. Jain,et al. Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts. , 2001, Cancer research.
[31] N. Fusenig,et al. Angiogenesis inhibition by vascular endothelial growth factor receptor-2 blockade reduces stromal matrix metalloproteinase expression, normalizes stromal tissue, and reverts epithelial tumor phenotype in surface heterotransplants. , 2005, Cancer research.
[32] Rakesh K. Jain,et al. Pathology: Cancer cells compress intratumour vessels , 2004, Nature.
[33] Rakesh K Jain,et al. Mosaic tumor vessels: cellular basis and ultrastructure of focal regions lacking endothelial cell markers. , 2005, Cancer research.
[34] A. Giaccia,et al. The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. , 1998, Cancer research.
[35] P. C. Johnson. Landis Award Lecture. The myogenic response and the microcirculation. , 1977, Microvascular research.
[36] Gary G. Meadows,et al. Integration/Interaction of Oncologic Growth , 2005 .
[37] Lei Xu,et al. Tumour biology: Herceptin acts as an anti-angiogenic cocktail , 2002, Nature.
[38] Melody A. Swartz,et al. Interstitial Flow as a Guide for Lymphangiogenesis , 2003, Circulation research.
[39] I. Tannock,et al. Influence of low pH on cytotoxicity of paclitaxel, mitoxantrone and topotecan. , 1997, British Journal of Cancer.
[40] T. Tlsty,et al. Stromal cells can contribute oncogenic signals. , 2001, Seminars in cancer biology.
[41] R. Jain. Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy , 2005, Science.
[42] S. Heiland,et al. Trimodal cancer treatment: beneficial effects of combined antiangiogenesis, radiation, and chemotherapy. , 2005, Cancer research.
[43] Zvi Fuks,et al. Tumor Response to Radiotherapy Regulated by Endothelial Cell Apoptosis , 2003, Science.
[44] R K Jain,et al. Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse. , 1992, Cancer research.
[45] R K Jain,et al. Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows. , 1994, Cancer research.
[46] R K Jain,et al. Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[47] Janice M. Y. Brown,et al. The hypoxic cell: a target for selective cancer therapy--eighteenth Bruce F. Cain Memorial Award lecture. , 1999, Cancer research.
[48] Dai Fukumura,et al. Peritumor Lymphatics Induced by Vascular Endothelial Growth Factor-C Exhibit Abnormal Function , 2004, Cancer Research.
[49] Lei Xu,et al. Pancreas Microenvironment Promotes VEGF Expression and Tumor Growth: Novel Window Models for Pancreatic Tumor Angiogenesis and Microcirculation , 2001, Laboratory Investigation.
[50] Jeffrey W. Clark,et al. Lessons from phase III clinical trials on anti-VEGF therapy for cancer , 2006, Nature Clinical Practice Oncology.
[51] R K Jain,et al. Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor. , 1999, Cancer research.
[52] Dennis C. Sgroi,et al. Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion , 2005, Cell.
[53] R K Jain,et al. Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo. , 2001, Cancer research.
[54] Dai Fukumura,et al. Tumor microenvironment abnormalities: Causes, consequences, and strategies to normalize , 2007, Journal of cellular biochemistry.
[55] M Ancukiewicz,et al. Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions. , 2000, Cancer research.
[56] R. Jain,et al. Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[57] V. Grégoire,et al. Thalidomide radiosensitizes tumors through early changes in the tumor microenvironment. , 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.
[58] I. Fidler,et al. Angiogenic heterogeneity: regulation of neoplastic angiogenesis by the organ microenvironment. , 2001, Journal of the National Cancer Institute.
[59] D. Ruiter,et al. Tumour metastasis: is tissue an issue? , 2001, The Lancet. Oncology.
[60] Dai Fukumura,et al. Dissecting tumour pathophysiology using intravital microscopy , 2002, Nature Reviews Cancer.
[61] R. Xavier,et al. Tumor Induction of VEGF Promoter Activity in Stromal Cells , 1998, Cell.
[62] Dai Fukumura,et al. Imaging steps of lymphatic metastasis reveals that vascular endothelial growth factor-C increases metastasis by increasing delivery of cancer cells to lymph nodes: therapeutic implications. , 2006, Cancer research.
[63] Ricky T. Tong,et al. Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model. , 2007, Cancer research.
[64] R. Skalak,et al. Time-dependent behavior of interstitial fluid pressure in solid tumors: implications for drug delivery. , 1995, Cancer research.
[65] B Landuyt,et al. Effect of antivascular endothelial growth factor treatment on the intratumoral uptake of CPT-11 , 2003, British Journal of Cancer.
[66] J. Pollard. Tumour-educated macrophages promote tumour progression and metastasis , 2004, Nature Reviews Cancer.
[67] Rakesh K. Jain,et al. Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation , 1997, Nature Medicine.
[68] M Intaglietta,et al. Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[69] L. Coussens,et al. Paradoxical roles of the immune system during cancer development , 2006, Nature Reviews Cancer.
[70] R K Jain,et al. Fluorescence ratio imaging measurement of pH gradients: calibration and application in normal and tumor tissues. , 1993, Microvascular research.
[71] Lei Xu,et al. Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis. , 2006, Cancer research.
[72] C. Bucana,et al. Regulation of interleukin-8 expression in human melanoma cells by the organ environment. , 1995, Cancer research.
[73] Rakesh K. Jain,et al. Vascular Normalization by Vascular Endothelial Growth Factor Receptor 2 Blockade Induces a Pressure Gradient Across the Vasculature and Improves Drug Penetration in Tumors , 2004, Cancer Research.
[74] Quynh-Thu Le,et al. Lysyl oxidase is essential for hypoxia-induced metastasis , 2006, Nature.
[75] Lei Xu,et al. Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. , 2004, Cancer cell.
[76] Robert S. Kerbel,et al. The anti-angiogenic basis of metronomic chemotherapy , 2004, Nature Reviews Cancer.
[77] James L Tatum,et al. Hypoxia: Importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy , 2006, International journal of radiation biology.
[78] R. Jain,et al. Absence of functional lymphatics within a murine sarcoma: a molecular and functional evaluation. , 2000, Cancer research.
[79] R K Jain,et al. Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[80] Ricky T. Tong,et al. Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[81] R K Jain,et al. Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy. , 1990, Cancer research.
[82] Rakesh K Jain,et al. Molecular regulation of vessel maturation , 2003, Nature Medicine.
[83] C. Bucana,et al. Organ site-dependent expression of basic fibroblast growth factor in human renal cell carcinoma cells. , 1994, The American journal of pathology.
[84] D. Fukumura,et al. Hypoxia-Induced Activation of p38 Mitogen-Activated Protein Kinase and Phosphatidylinositol 3′-Kinase Signaling Pathways Contributes to Expression of Interleukin 8 in Human Ovarian Carcinoma Cells , 2004, Clinical Cancer Research.
[85] Tatiana V. Petrova,et al. Lymphangiogenesis in development and human disease , 2005, Nature.
[86] Rakesh K. Jain,et al. Transport of molecules across tumor vasculature , 2004, Cancer and Metastasis Reviews.
[87] J. Pouysségur,et al. Hypoxia signalling in cancer and approaches to enforce tumour regression , 2006, Nature.
[88] J. Foidart,et al. Enhancement of tumorigenicity of human breast adenocarcinoma cells in nude mice by matrigel and fibroblasts. , 1993, British Journal of Cancer.
[89] P. Choyke,et al. Imaging of angiogenesis: from microscope to clinic , 2003, Nature Medicine.
[90] R. Weinberg,et al. The Biology of Cancer , 2006 .
[91] Adrian L. Harris,et al. Hypoxia — a key regulatory factor in tumour growth , 2002, Nature Reviews Cancer.
[92] R. Weinberg,et al. Systemic stromal effects of estrogen promote the growth of estrogen receptor-negative cancers. , 2007, Cancer research.