Immunolocalization of urokinase‐type plasminogen activator in adenomas and carcinomas of the colorectum

Carcinogenesis in the human colon is associated with a marked increase in the tissue content of the urokinase‐type plasmmogen activator (u‐PA). This study was performed to determine the type of cells responsible for the u‐PA increase in carcinomas of the colon and in their precursor lesions, the adenomas, by immunohistological evaluation applying monoclonal antibody 3689 directed to the β‐chain of u‐PA.

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