A fetus with Down syndrome and intratubular germ cell neoplasia.

A 22-week-old fetus with trisomy 21 demonstrated intratubular germ cell neoplasia. This is the second report of in situ testicular neoplasia in a fetus with trisomy 21, suggesting that the mechanism responsible for the possible excess of testicular germ cell tumors that occur in Down syndrome is operative in early fetal life. Because no examples of neonatal testicular germ cell tumor in trisomy 21 have been reported, we suggest that this in situ neoplasm may disappear during gestation, such as the trisomy 21-associated transient myeloproliferative syndrome does shortly after birth. This disappearance may be due to a controlled regression phenomenon.

[1]  A. Homans,et al.  Transient abnormal myelopoiesis of infancy associated with trisomy 21. , 1993, The American journal of pediatric hematology/oncology.

[2]  R. Kay.  Prepubertal testicular tumor registry. , 1993, The Urologic clinics of North America.

[3]  G. Jacobsen,et al.  Intratubular germ cell neoplasia in an infantile testis with immature teratoma , 1993, Histopathology.

[4]  G. Jacobsen,et al.  A fetal testis with intratubular germ cell neoplasia (ITGCN). , 1992, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.

[5]  T. McConnell,et al.  Prenatal diagnosis of transient myeloproliferative disorder via percutaneous umbilical blood sampling. Report of two cases in fetuses affected by Down's syndrome. , 1992, American journal of clinical pathology.

[6]  A. Zipursky,et al.  Leukemia in Down syndrome: a review. , 1992, Pediatric hematology and oncology.

[7]  C. Stiller,et al.  An estimate of the heritable fraction of childhood cancer. , 1991, British Journal of Cancer.

[8]  H. Kurahashi,et al.  Monoclonal nature of transient abnormal myelopoiesis in Down's syndrome. , 1991, Blood.

[9]  J. Mann,et al.  Results of the United Kingdom children's cancer study group's malignant germ cell tumor studies , 1990, Cancer.

[10]  D. Satgé.  Cytogenetic anomalies in neonatal and fetal solid tumors , 1989 .

[11]  C. Logothetis,et al.  Genetic abnormalities in men with germ cell tumors. , 1988, The Journal of urology.

[12]  N. Skakkebaek,et al.  Testicular carcinoma in situ in children with the androgen insensitivity (testicular feminisation) syndrome. , 1984, British medical journal.

[13]  N. Skakkebaek,et al.  Epidemiological and clinical aspects of carcinoma in situ of the testis. , 1993, European urology.

[14]  Becroft Dm,et al.  Perinatal visceral fibrosis accompanying the megakaryoblastic leukemoid reaction of Down syndrome. , 1990 .

[15]  H. Rehder,et al.  Quantitative histology of human fetal testes in chromosomal disease. , 1985, Pediatric pathology.

[16]  R. Bolande.  Spontaneous regression and cytodifferentiation of cancer in early life: the oncogenic grace period. , 1985, Survey and synthesis of pathology research.

[17]  N. Skakkebæk,et al.  Cryptorchidism and testis cancer. Atypical infantile germ cells followed by carcinoma in situ and invasive carcinoma in adulthood , 1984, Cancer.