Ajuba inhibits hepatocellular carcinoma cell growth via targeting of β-catenin and YAP signaling and is regulated by E3 ligase Hakai through neddylation
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Dapeng Liang | Songshu Meng | G. Yao | P. Liu | Min Liu | M. Barr | Yang Wang | P. Gong | H. Piao | Yumei Yan | K. Jiang | T. Ye | Guibin Lin | Peng Liu
[1] Xia Li,et al. Basolateral CD147 induces hepatocyte polarity loss by E‐cadherin ubiquitination and degradation in hepatocellular carcinoma progress , 2018, Hepatology.
[2] Yang Shi,et al. Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal. , 2018, Molecular cell.
[3] Jeong-Hwan Kim,et al. Hippo-mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer , 2018, The Journal of clinical investigation.
[4] H. Lee,et al. Tumor‐adjacent tissue co‐expression profile analysis reveals pro‐oncogenic ribosomal gene signature for prognosis of resectable hepatocellular carcinoma , 2017, Molecular oncology.
[5] Yuxi Li,et al. Hippo signaling pathway in liver tissue homeostasis. , 2017, Yi chuan = Hereditas.
[6] P. Schirmacher,et al. Induction of Chromosome Instability by Activation of Yes-Associated Protein and Forkhead Box M1 in Liver Cancer. , 2017, Gastroenterology.
[7] Huanbai Xu,et al. The LIM protein AJUBA promotes colorectal cancer cell survival through suppression of JAK1/STAT1/IFIT2 network , 2017, Oncogene.
[8] Xianming Deng,et al. Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2. , 2017, Cancer cell.
[9] Yue Wang,et al. The oncoprotein HBXIP up-regulates YAP through activation of transcription factor c-Myb to promote growth of liver cancer. , 2017, Cancer Letters.
[10] E. Jho,et al. Hippo signaling interactions with Wnt/&bgr;-catenin and Notch signaling repress liver tumorigenesis , 2017, The Journal of clinical investigation.
[11] G. Longmore,et al. AJUBA LIM Proteins Limit Hippo Activity in Proliferating Cells by Sequestering the Hippo Core Kinase Complex in the Cytosol , 2016, Molecular and Cellular Biology.
[12] Xueda Hu,et al. AJUBA promotes the migration and invasion of esophageal squamous cell carcinoma cells through upregulation of MMP10 and MMP13 expression , 2016, Oncotarget.
[13] Han Liu,et al. Tumor suppressor Spred2 interaction with LC3 promotes autophagosome maturation and induces autophagy-dependent cell death , 2016, Oncotarget.
[14] G. Mills,et al. Yes‐associated protein 1 and transcriptional coactivator with PDZ‐binding motif activate the mammalian target of rapamycin complex 1 pathway by regulating amino acid transporters in hepatocellular carcinoma , 2016, Hepatology.
[15] Songshu Meng,et al. Oncolytic newcastle disease virus triggers cell death of lung cancer spheroids and is enhanced by pharmacological inhibition of autophagy. , 2015, American journal of cancer research.
[16] E. Oki,et al. An Imbalance in TAZ and YAP Expression in Hepatocellular Carcinoma Confers Cancer Stem Cell-like Behaviors Contributing to Disease Progression. , 2015, Cancer research.
[17] W. Liu,et al. Ajuba Preferentially Binds LXRα/RXRγ Heterodimer to Enhance LXR Target Gene Expression in Liver Cells. , 2015, Molecular endocrinology.
[18] G. Longmore,et al. Ajuba proteins , 2015, Current Biology.
[19] Huanming Yang,et al. Genomic Analyses Reveal Mutational Signatures and Frequently Altered Genes in Esophageal Squamous Cell Carcinoma , 2015, American journal of human genetics.
[20] J. Llovet,et al. YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression. , 2015, Cell reports.
[21] Xianming Deng,et al. Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis , 2015, Nature Communications.
[22] Steven J. M. Jones,et al. Comprehensive genomic characterization of head and neck squamous cell carcinomas , 2015, Nature.
[23] Lanfen Chen,et al. The Hippo signaling pathway in liver regeneration and tumorigenesis. , 2015, Acta biochimica et biophysica Sinica.
[24] Curtis R. Pickering,et al. Mutational Landscape of Aggressive Cutaneous Squamous Cell Carcinoma , 2014, Clinical Cancer Research.
[25] J. Madri,et al. Adhesion Molecule-Mediated Hippo Pathway Modulates Hemangioendothelioma Cell Behavior , 2014, Molecular and Cellular Biology.
[26] Jian Sun,et al. Genetic landscape of esophageal squamous cell carcinoma , 2014, Nature Genetics.
[27] Lei Zhang,et al. LIM protein JUB promotes epithelial–mesenchymal transition in colorectal cancer , 2014, Cancer science.
[28] Y. Kondo,et al. LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade , 2013, Oncogene.
[29] D. Moore,et al. Bile acids activate YAP to promote liver carcinogenesis. , 2013, Cell reports.
[30] Makoto Naito,et al. Identification of Wilms' Tumor 1-associating Protein Complex and Its Role in Alternative Splicing and the Cell Cycle* , 2013, The Journal of Biological Chemistry.
[31] Takanori Fujita,et al. PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer , 2013, Scientific Reports.
[32] Jun Du,et al. c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-β type II receptor. , 2013, Molecular cell.
[33] Angélica Figueroa,et al. miR-203 Regulates Cell Proliferation through Its Influence on Hakai Expression , 2012, PloS one.
[34] J. Seetharaman,et al. Structure of a novel phosphotyrosine‐binding domain in Hakai that targets E‐cadherin , 2012, The EMBO journal.
[35] Angélica Figueroa,et al. Biological influence of Hakai in cancer: a 10-year review , 2012, Cancer and Metastasis Reviews.
[36] C. Cartwright,et al. Rack1 promotes epithelial cell–cell adhesion by regulating E-cadherin endocytosis , 2012, Oncogene.
[37] M. Bailly,et al. Ajuba is required for Rac activation and maintenance of E-cadherin adhesion , 2011, The Journal of cell biology.
[38] Angélica Figueroa,et al. Hakai reduces cell-substratum adhesion and increases epithelial cell invasion , 2011, BMC Cancer.
[39] J. Geng,et al. Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis , 2011, Cell Research.
[40] Keesook Lee,et al. Hakai acts as a coregulator of estrogen receptor alpha in breast cancer cells , 2010, Cancer science.
[41] G. Longmore,et al. Ajuba LIM Proteins Are Negative Regulators of the Hippo Signaling Pathway , 2010, Current Biology.
[42] J. Llovet,et al. Molecular classification and novel targets in hepatocellular carcinoma: recent advancements. , 2010, Seminars in liver disease.
[43] Ping Li,et al. Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ. , 2010, Molecular cell.
[44] M. Gorospe,et al. Hacking RNA: Hakai promotes tumorigenesis by enhancing the RNA-binding function of PSF , 2009, Cell cycle.
[45] M. Gorospe,et al. Novel roles of hakai in cell proliferation and oncogenesis. , 2009, Molecular biology of the cell.
[46] Amanda Doucette,et al. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer , 2009, Nature.
[47] Ellen M. Langer,et al. Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus. , 2008, Developmental cell.
[48] T. Akiyama,et al. Ajuba negatively regulates the Wnt signaling pathway by promoting GSK-3β-mediated phosphorylation of β-catenin , 2008, Oncogene.
[49] T. Akiyama,et al. Ajuba negatively regulates the Wnt signaling pathway by promoting GSK-3beta-mediated phosphorylation of beta-catenin. , 2008, Oncogene.
[50] Derek Y. Chiang,et al. Genomics and signaling pathways in hepatocellular carcinoma. , 2007, Seminars in liver disease.
[51] S. Boyault,et al. Differential effects of inactivated Axin1 and activated β-catenin mutations in human hepatocellular carcinomas , 2007, Oncogene.
[52] S. Boyault,et al. Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets , 2007, Hepatology.
[53] G. Cesareni,et al. Conjugation to Nedd8 Instigates Ubiquitylation and Down-regulation of Activated Receptor Tyrosine Kinases* , 2006, Journal of Biological Chemistry.
[54] Songshu Meng,et al. Participation of both Gab1 and Gab2 in the activation of the ERK/MAPK pathway by epidermal growth factor. , 2005, The Biochemical journal.
[55] M. Beckerle,et al. The LIM domain: from the cytoskeleton to the nucleus , 2004, Nature Reviews Molecular Cell Biology.
[56] K. Green. Faculty Opinions recommendation of Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. , 2002 .
[57] W. Birchmeier,et al. Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex , 2002, Nature Cell Biology.
[58] Yusuke Nakamura,et al. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1 , 2000, Nature Genetics.