ISL1 predicts poor outcomes for patients with gastric cancer and drives tumor progression through binding to the ZEB1 promoter together with SETD7

[1]  Daesik Kim,et al.  Genome editing reveals a role for OCT4 in human embryogenesis , 2017, Nature.

[2]  Ling Li,et al.  Long noncoding RNA ZEB1-AS1 epigenetically regulates the expressions of ZEB1 and downstream molecules in prostate cancer , 2017, Molecular Cancer.

[3]  Sufei He,et al.  Potential role of ZEB1 as a DNA repair regulator in colorectal cancer cells revealed by cancer-associated promoter profiling , 2017, Oncology reports.

[4]  Huidong Shi,et al.  The MLL1-H3K4me3 Axis-Mediated PD-L1 Expression and Pancreatic Cancer Immune Evasion , 2017, Journal of the National Cancer Institute.

[5]  C. Pilarsky,et al.  The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer , 2017, Nature Cell Biology.

[6]  R. Weinberg,et al.  EMT, CSCs, and drug resistance: the mechanistic link and clinical implications , 2017, Nature Reviews Clinical Oncology.

[7]  Jie He,et al.  Cancer incidence and mortality in China in 2013: an analysis based on urbanization level , 2017, Chinese journal of cancer research = Chung-kuo yen cheng yen chiu.

[8]  G. Lenz,et al.  Roles of OCT4 in tumorigenesis, cancer therapy resistance and prognosis. , 2016, Cancer treatment reviews.

[9]  Bing Ren,et al.  Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition , 2016, Nature.

[10]  Ping Chen,et al.  ISL1, a novel regulator of CCNB1, CCNB2 and c-MYC genes, promotes gastric cancer cell proliferation and tumor growth , 2016, Oncotarget.

[11]  D. Reinberg,et al.  ISL1 and JMJD3 synergistically control cardiac differentiation of embryonic stem cells , 2016, Nucleic acids research.

[12]  A. Stensballe,et al.  Mass spectrometry analysis of adipose-derived stem cells reveals a significant effect of hypoxia on pathways regulating extracellular matrix , 2016, Stem Cell Research & Therapy.

[13]  C. Meisinger,et al.  ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types , 2016, Nature Communications.

[14]  Ping Chen,et al.  ISL-1 promotes pancreatic islet cell proliferation by forming an ISL-1/Set7/9/PDX-1 complex , 2015, Cell cycle.

[15]  Raja Jothi,et al.  DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis , 2015, Nature Communications.

[16]  A. Jemal,et al.  Global cancer statistics, 2012 , 2015, CA: a cancer journal for clinicians.

[17]  F. Portillo,et al.  Zeb1 and Snail1 engage miR‐200f transcriptional and epigenetic regulation during EMT , 2015, International journal of cancer.

[18]  J. Herman,et al.  Epigenetic changes and functional study of HOXA11 in human gastric cancer. , 2015, Epigenomics.

[19]  Ping Chen,et al.  ISL-1 is overexpressed in non-Hodgkin lymphoma and promotes lymphoma cell proliferation by forming a p-STAT3/p-c-Jun/ISL-1 complex , 2014, Molecular Cancer.

[20]  Yasuhiko Irie,et al.  ChIP-Seq and RNA-Seq Reveal an AmrZ-Mediated Mechanism for Cyclic di-GMP Synthesis and Biofilm Development by Pseudomonas aeruginosa , 2014, PLoS pathogens.

[21]  Robert A. Weinberg,et al.  Poised Chromatin at the ZEB1 Promoter Enables Breast Cancer Cell Plasticity and Enhances Tumorigenicity , 2013, Cell.

[22]  Wei Zhao,et al.  1B50-1, a mAb raised against recurrent tumor cells, targets liver tumor-initiating cells by binding to the calcium channel α2δ1 subunit. , 2013, Cancer cell.

[23]  M. Vieth,et al.  ISL1 expression is not restricted to pancreatic well-differentiated neuroendocrine neoplasms, but is also commonly found in well and poorly differentiated neuroendocrine neoplasms of extrapancreatic origin , 2013, Modern Pathology.

[24]  S. B. Nielsen,et al.  Islet-1 is a dual regulator of fibrogenic epithelial-to-mesenchymal transition in epicardial mesothelial cells. , 2013, Experimental cell research.

[25]  Y. Toiyama,et al.  Clinical significance of zinc finger E‐box binding homeobox 1 (ZEB1) in human gastric cancer , 2012, Journal of surgical oncology.

[26]  Marta García,et al.  The EMT signaling pathways in endometrial carcinoma , 2012, Clinical and Translational Oncology.

[27]  Aik Choon Tan,et al.  Patient-derived tumour xenografts as models for oncology drug development , 2012, Nature Reviews Clinical Oncology.

[28]  Shawn P. Driscoll,et al.  ES cell potency fluctuates with endogenous retrovirus activity , 2012, Nature.

[29]  M. Laiho,et al.  LIM-domain proteins in transforming growth factor β-induced epithelial-to-mesenchymal transition and myofibroblast differentiation. , 2012, Cellular signalling.

[30]  Yuval Kluger,et al.  PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes. , 2012, Molecular cell.

[31]  D. Ichikawa,et al.  Differences of the Lymphatic Distribution and Surgical Outcomes Between Remnant Gastric Cancers and Primary Proximal Gastric Cancers , 2012, Journal of Gastrointestinal Surgery.

[32]  Ping Chen,et al.  ISL1 Promotes Pancreatic Islet Cell Proliferation , 2011, PloS one.

[33]  Tianshu Liu,et al.  Lentiviral-mediated siRNA targeted against osteopontin suppresses the growth and metastasis of gastric cancer cells. , 2011, Oncology reports.

[34]  Helga Thorvaldsdóttir,et al.  Integrative Genomics Viewer , 2011, Nature Biotechnology.

[35]  K. Helin,et al.  Histone methyltransferases in cancer. , 2010, Seminars in cell & developmental biology.

[36]  Julia Schüler,et al.  The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs , 2009, Nature Cell Biology.

[37]  Y. Mok,et al.  Surgical outcomes and prognostic factors for T4 gastric cancers. , 2009, Asian journal of surgery.

[38]  Ping Chen,et al.  The LIM-homeodomain protein ISL1 activates insulin gene promoter directly through synergy with BETA2. , 2009, Journal of molecular biology.

[39]  T. Borodina,et al.  Transcriptome analysis by strand-specific sequencing of complementary DNA , 2009, Nucleic acids research.

[40]  K. Zhao,et al.  Detection of single nucleotide variations in expressed exons of the human genome using RNA-Seq , 2009, Nucleic acids research.

[41]  H. Grabsch,et al.  Inhibition of gastric cancer invasion and metastasis by PLA2G2A, a novel beta-catenin/TCF target gene. , 2008, Cancer research.

[42]  M. Wheeler,et al.  Transcription factor expression in the developing human fetal endocrine pancreas , 2008, Diabetologia.

[43]  A. Osunkoya,et al.  Insulin-like growth factor-I-dependent up-regulation of ZEB1 drives epithelial-to-mesenchymal transition in human prostate cancer cells. , 2008, Cancer research.

[44]  R. Jaenisch,et al.  A Chromatin Landmark and Transcription Initiation at Most Promoters in Human Cells , 2007, Cell.

[45]  T. Kouzarides Chromatin Modifications and Their Function , 2007, Cell.

[46]  G. Berx,et al.  A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer. , 2006, Gastroenterology.

[47]  James A. Cuff,et al.  A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells , 2006, Cell.

[48]  R. Kingston,et al.  Chromatin Compaction by a Polycomb Group Protein Complex , 2004, Science.

[49]  Yunqing Shi,et al.  Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. , 2003, Developmental cell.

[50]  Brad T. Sherman,et al.  DAVID: Database for Annotation, Visualization, and Integrated Discovery , 2003, Genome Biology.

[51]  D. Reinberg,et al.  Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation. , 2002, Genes & development.

[52]  M. S. Lee,et al.  c-Myc expression is related with cell proliferation and associated with poor clinical outcome in human gastric cancer. , 1999, Journal of Korean medical science.

[53]  T. Jessell,et al.  Requirement for LIM Homeobox Gene Isl1 in Motor Neuron Generation Reveals a Motor Neuron– Dependent Step in Interneuron Differentiation , 1996, Cell.

[54]  A. Jemal,et al.  Global cancer statistics , 2011, CA: a cancer journal for clinicians.

[55]  Brad T. Sherman,et al.  DAVID: Database for Annotation, Visualization, and Integrated Discovery , 2003, Genome Biology.