A Non-epithelial Pseudosarcomatous Mural Nodule in a Mucinous Cystic Neoplasm of the Pancreas

A mucinous cystic neoplasm of indeterminate malignant potential was found to have a well-circumscribed, 3.1 cm pseudosarcomatous mural nodule, similar to those previously described in the ovary. The nodule contained reactive giant cells and intermediate to large-sized tumor cells with bizarre mitotic figures and nuclear atypia. The tumor cells were found to be of non-epithelial origin, based on multiple negative stains for cytokeratins and ultrastructural demonstration of osteoclastic and osteoblastic differentiation and absent desmosomes. This case report is the only description of a pseudosarcomatous mural nodule in a mucinous cystic neoplasm with non-epithelial origins.

[1]  S. Bergman,et al.  Giant cell tumor of the pancreas arising in the ovarian-like stroma of a mucinous cystadenocarcinoma , 1995, International journal of pancreatology : official journal of the International Association of Pancreatology.

[2]  Y. Sasaguri,et al.  Ovarian mucinous cystadenocarcinoma with sarcoma‐like mural nodules , 1995, Journal of surgical oncology.

[3]  F. Schmitt,et al.  Pancreatic mucinous cystadenocarcinoma with a mural nodule of anaplastic carcinoma , 1995, Histopathology.

[4]  M. Taniguchi,et al.  Malignant fibrous histiocytoma coexistent with mucinous cystadenoma of the pancreas , 1992, Cancer.

[5]  P. R. Ros,et al.  Cystic masses of the pancreas. , 1992, Radiographics : a review publication of the Radiological Society of North America, Inc.

[6]  Augusto Álvarez García,et al.  Pancreatic mucinous cystadenocarcinoma with pseudosarcomatous mural nodules. A report of a case with immunohistochemical study , 1991 .

[7]  B. Ellis,et al.  Osteoclast-type giant cell tumour of the pancreas. , 1983, Journal of clinical pathology.

[8]  S. Jalloh.  Giant cell tumour (osteoclastoma) of the pancreas--an epithelial tumour probably of pancreatic acinar origin. , 1983, Journal of clinical pathology.

[9]  V. Livolsi,et al.  Giant cell tumor (“osteoclastoma”) of the pancreas: A tumor of epithelial origin , 1981, Cancer.

[10]  J. Posen,et al.  Giant cell tumor of the pancreas of the osteoclastic type associated with a mucous secreting cystadenocarcinoma. , 1981, Human pathology.

[11]  R. Scully,et al.  Sarcomas in ovarian mucinous tumors.A report of two cases , 1979, Cancer.

[12]  R. Scully,et al.  Ovarian mucinous tumors with sarcoma‐like mural nodules. A report of seven cases , 1979, Cancer.

[13]  L. Weiland,et al.  The histologic spectrum, prognosis, and histogenesis of the sarcomatoid carcinoma of the pancreas , 1977, Cancer.

[14]  S. Kay,et al.  Unusual pleomorphic carcinoma of the pancreas featuring production of osteoid , 1969, Cancer.

[15]  J. Rosal,et al.  Carcinoma of pancreas simulating giant cell tumor of bone. Electron‐microscopic evidence of its acinar cell origin , 1968, Cancer.

[16]  R. Berendt,et al.  The osteoclast-type giant cell tumor of the pancreas. , 1987, Archives of pathology & laboratory medicine.

[17]  R. Dgani,et al.  Ovarian mucinous cystadenocarcinoma with mural nodule of carcinomatous derivation a light and electron microscopic study , 1983, Cancer.